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ARHGEF6 and SH2D1A
Number of citations of the paper that reports this interaction (PubMedID
16983070
)
37
Data Source:
HPRD
(two hybrid, in vivo)
ARHGEF6
SH2D1A
Description
Rac/Cdc42 guanine nucleotide exchange factor 6
SH2 domain containing 1A
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Cell-cell Junction
Lamellipodium
Cell Projection
Cytoplasm
Cytosol
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Protein Binding
Protein Binding
Protein-macromolecule Adaptor Activity
Biological Process
Apoptotic Process
JNK Cascade
Lamellipodium Assembly
Adaptive Immune Response
Immune System Process
Humoral Immune Response
Cellular Defense Response
Cell-cell Signaling
Natural Killer Cell Activation
Natural Killer Cell Mediated Cytotoxicity
Innate Immune Response
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Regulation Of Immune Response
Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways
NRAGE signals death through JNK
G alpha (12/13) signalling events
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
G beta:gamma signalling through CDC42
CDC42 GTPase cycle
RAC1 GTPase cycle
RHOU GTPase cycle
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
Non-syndromic X-linked mental retardation
Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS
Autism spectrum disorder (
34069769
)
Breast cancer (
29059683
)
Interacting Genes
36 interacting genes:
ADAM15
ARAP3
ARHGEF7
BMPR1B
CAPNS1
CBFA2T3
CCDC33
CDC42
EPHB2
GIT1
GOLGA2
GPRASP2
HSF2BP
KRT27
NUTM1
PAK1
PAK2
PAK3
PARVB
PNMA1
POU6F2
RWDD2A
SH2D1A
SH3GL3
SIRPA
SMAD1
SMAD2
SMAD3
TGFBR1
TGFBR2
TMEM108
TP53BP2
TRAF2
TRIM54
YWHAG
ZNF580
32 interacting genes:
AR
ARHGEF6
ARHGEF7
ATF3
CCDC74A
CD84
DOK1
EGFR
ERBB2
ERBB3
ERBB4
FYB1
FYN
GRB2
KIT
LCK
LETMD1
LHX3
LHX4
LY9
MAPK11
MAPK14
MET
NCK1
NGEF
OLIG1
PTK2
SLAMF1
SLAMF6
SLAMF7
TNK2
ZNHIT1
Entrez ID
9459
4068
HPRD ID
02226
02390
Ensembl ID
ENSG00000129675
ENSG00000183918
Uniprot IDs
B7Z3C7
Q15052
Q8N4Q3
O60880
PDB IDs
1UJY
1WYR
1D1Z
1D4T
1D4W
1KA6
1KA7
1M27
Enriched GO Terms of Interacting Partners
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Enzyme-linked Receptor Protein Signaling Pathway
Response To Growth Factor
Dendritic Spine Development
I-SMAD Binding
Cellular Response To Growth Factor Stimulus
Regulation Of Cytoskeleton Organization
Regulation Of Supramolecular Fiber Organization
Ephrin Receptor Signaling Pathway
SMAD Protein Signal Transduction
SMAD Protein Complex
Trophoblast Cell Migration
Heteromeric SMAD Protein Complex
Embryonic Cranial Skeleton Morphogenesis
Activin Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Regulation Of Stress Fiber Assembly
Co-SMAD Binding
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Primary MiRNA Processing
Transforming Growth Factor Beta Receptor Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
SMAD Binding
Protein Kinase Binding
Homomeric SMAD Protein Complex
Positive Regulation Of Stress Fiber Assembly
Regulation Of Actin Cytoskeleton Organization
Dendritic Spine Morphogenesis
Positive Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Microtubule Nucleation
Protein Kinase Activity
Positive Regulation Of Actin Filament Bundle Assembly
Cellular Response To Lectin
Stimulatory C-type Lectin Receptor Signaling Pathway
Paraxial Mesoderm Morphogenesis
Transforming Growth Factor Beta Ligand-receptor Complex
Regulation Of Actin Filament-based Process
Response To Transforming Growth Factor Beta
Immune System Process
Regulation Of Cartilage Development
Protein Serine/threonine Kinase Activity
Regulation Of Cellular Component Organization
Positive Regulation Of Cell Migration
Regulation Of Actin Filament Organization
Response To Cholesterol
Roof Of Mouth Development
Response To Stress
Positive Regulation Of Cell Motility
Regulation Of Organelle Organization
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Tyrosine Kinase Activity
Lymphocyte Activation
Positive Regulation Of Metabolic Process
Cell Activation
Protein Kinase Activity
T Cell Activation
Cell Surface Receptor Signaling Pathway
Cellular Developmental Process
Leukocyte Activation
Kinase Activity
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Biosynthetic Process
Cell Differentiation
Regulation Of Immune System Process
ERBB Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Gene Expression
Regulation Of Programmed Cell Death
Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Protein Phosphatase Binding
Regulation Of Multicellular Organismal Process
Intracellular Signaling Cassette
Intracellular Signal Transduction
Peptidyl-tyrosine Phosphorylation
Ephrin Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Activity
Signal Transduction
ERBB2 Signaling Pathway
Positive Regulation Of MAPK Cascade
Basal Plasma Membrane
Ephrin Receptor Binding
Regulation Of Metabolic Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Negative Regulation Of Programmed Cell Death
Immune System Process
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Intracellular Signal Transduction
Lamellipodium Assembly
Animal Organ Development
Immune Response-regulating Signaling Pathway
Regulation Of Immune Response
Regulation Of Apoptotic Process
SH2 Domain Binding
Adaptive Immune Response
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Tagcloud (Intersection)
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