TGFBR2 and CCNB1

Number of citations of the paper that reports this interaction (PubMedID 9926943)
0

Data Source:
HPRD (in vivo)

		TGFBR2	CCNB1
Description		transforming growth factor beta receptor 2	cyclin B1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane Caveola External Side Of Plasma Membrane Cell Surface Membrane Nuclear Body Receptor Complex Membrane Raft Activin Receptor Complex Transforming Growth Factor Beta Ligand-receptor Complex	Spindle Pole Outer Kinetochore Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Membrane Cyclin B1-CDK1 Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type II Protein Binding ATP Binding Glycosaminoglycan Binding Kinase Activity Activin Receptor Activity, Type I Transferase Activity Kinase Activator Activity Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Signaling Receptor Activity SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding Molecular Adaptor Activity	Patched Binding Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Ubiquitin-like Protein Ligase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	Blood Vessel Development Branching Involved In Blood Vessel Morphogenesis Vasculogenesis In Utero Embryonic Development Epithelial To Mesenchymal Transition Heart Looping Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Positive Regulation Of Tolerance Induction To Self Antigen Positive Regulation Of B Cell Tolerance Induction Positive Regulation Of T Cell Tolerance Induction Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Outflow Tract Morphogenesis Aortic Valve Morphogenesis Atrioventricular Valve Morphogenesis Tricuspid Valve Morphogenesis Cardiac Left Ventricle Morphogenesis Endocardial Cushion Fusion Growth Plate Cartilage Development Growth Plate Cartilage Chondrocyte Growth Apoptotic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Smoothened Signaling Pathway Gastrulation Nervous System Development Brain Development Heart Development Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Cell Differentiation Lung Development Activin Receptor Signaling Pathway Response To Lipid Embryonic Hemopoiesis Aorta Morphogenesis Regulation Of Cell Population Proliferation Myeloid Dendritic Cell Differentiation Positive Regulation Of Angiogenesis Animal Organ Development Blood Vessel Morphogenesis Embryonic Cranial Skeleton Morphogenesis Artery Morphogenesis Positive Regulation Of Developmental Process Positive Regulation Of NK T Cell Differentiation Cartilage Development Regulation Of Multicellular Organismal Process Roof Of Mouth Development Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Lung Morphogenesis Bronchus Development Bronchus Morphogenesis Trachea Morphogenesis Trachea Formation Mammary Gland Morphogenesis Lung Lobe Morphogenesis Langerhans Cell Differentiation Secondary Palate Development Response To Cholesterol Cellular Response To Growth Factor Stimulus Regulation Of Stem Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cell Proliferation Involved In Endocardial Cushion Morphogenesis Superior Endocardial Cushion Morphogenesis Inferior Endocardial Cushion Morphogenesis Lens Fiber Cell Apoptotic Process MiRNA Transport Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Regulation Of Stem Cell Differentiation	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Oocyte Maturation In Utero Embryonic Development Mitotic Spindle Organization Mitotic Metaphase Chromosome Alignment Spermatogenesis Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Toxic Substance Negative Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of MRNA 3'-end Processing Tissue Regeneration Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Positive Regulation Of Mitotic Cell Cycle Response To DDT Positive Regulation Of Fibroblast Proliferation Digestive Tract Development Cell Division Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Chromosome Condensation Protein-containing Complex Assembly Cellular Response To Iron(III) Ion Cellular Response To Fatty Acid Cellular Response To Hypoxia Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Pathways		Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer UCH proteinases TGFBR3 regulates TGF-beta signaling	E2F-enabled inhibition of pre-replication complex formation Polo-like kinase mediated events Golgi Cisternae Pericentriolar Stack Reorganization APC/C:Cdc20 mediated degradation of Cyclin B Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of the APC/C Phosphorylation of Emi1 Condensation of Prophase Chromosomes MASTL Facilitates Mitotic Progression Resolution of Sister Chromatid Cohesion Condensation of Prometaphase Chromosomes Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Initiation of Nuclear Envelope (NE) Reformation Nuclear Pore Complex (NPC) Disassembly Depolymerization of the Nuclear Lamina TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Mitotic Prophase Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex The role of GTSE1 in G2/M progression after G2 checkpoint Transcriptional regulation by RUNX2 Nuclear events stimulated by ALK signaling in cancer Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs		Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Fostamatinib
Diseases		Loeys-Dietz syndrome (LDS) Colorectal cancer Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		Breast cancer ( 23535729 29059683) Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168) Cognitive decline rate in late mild cognitive impairment ( 26252872) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Migraine ( 22683712 27322543) Migraine - clinic-based ( 23793025) Night sleep phenotypes ( 27126917) Postprandial triglyceride response ( 32603185) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Systolic blood pressure ( 30224653) Tonometry ( 17903302)
Interacting Genes		51 interacting genes: ACVR1 ACVRL1 AP2B1 APP ARHGEF6 ARHGEF7 CCNB1 CCNB2 CD44 CDK1 CLU CRIPTO CTNNB1 DAB2 DAXX DYNLT4 EIF3I ENG FANCC GOPC KCNK18 MAP2K1 NRP1 OSR1 PAK1 PDGFRA PIK3R1 PIK3R2 PML PPP2CB PSMD14 RCVRN SMAD3 SMAD4 SMAD7 SNX6 STRAP TERT TGFB1 TGFB1I1 TGFB2 TGFB3 TGFBR1 TGFBR3 TGFBRAP1 TRAP1 TRMO TSSK1B USP8 ZFYVE9 ZNF510	64 interacting genes: ANAPC11 ARID4A BRCA1 BTG2 CCNB1IP1 CCNF CDC25A CDC25C CDC34 CDC6 CDH1 CDK1 CDKN1A CDKN1B CDT1 CEBPA CSNK2B CUX1 EP300 FLNA FZR1 GADD45A GADD45B GADD45G H1-1 H1-5 HERC5 ITPR1 KAT5 KPNB1 MAP4 MEF2C MOK NACC1 OGT OTUD7B PBK PCNA PIN1 PKMYT1 PLK1 PRC1 PRKDC PTCH1 PTMA RALBP1 RB1 RUNX2 TGFBR2 TP53BP1 TP73 TSC1 TSPYL2 TULP3 UBE2D2 UBE2N UBE3C UBE3D UCHL3 USP39 WEE1 XIAP XRCC6 ZFAND5
Entrez ID		7048	891
HPRD ID		01823	00454
Ensembl ID		ENSG00000163513	ENSG00000134057
Uniprot IDs		A0AAQ5BI06 A3QNQ0 D2JYI1 P37173	P14635
PDB IDs		1KTZ 1M9Z 1PLO 2PJY 3KFD 4P7U 4XJJ 5E8V 5E8Y 5E91 5E92 5QIN 5TX4 5TY4 7DV6 8G4K 8YGZ 9B9F 9E9G 9FDY 9FK5 9FKP	2B9R 2JGZ 4Y72 4YC3 5HQ0 5LQF 6GU2 6GU3 6GU4 7NJ0 8TAR 8TAU 9FH9
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Response To Growth Factor Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Binding Regulation Of Apoptotic Process Tissue Morphogenesis Heart Development Regulation Of Programmed Cell Death Positive Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Regulation Of Cell Population Proliferation Type II Transforming Growth Factor Beta Receptor Binding Regulation Of Signal Transduction Tube Morphogenesis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Cell Migration Positive Regulation Of Cell Communication Positive Regulation Of Signaling Anatomical Structure Morphogenesis I-SMAD Binding Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Cell Motility Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Locomotion Regulation Of Developmental Process Regulation Of Growth Regulation Of Cell Differentiation Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Cell Population Proliferation Regulation Of Cell Migration Multicellular Organism Development Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Differentiation Transforming Growth Factor Beta Binding Mesenchymal Cell Differentiation	Regulation Of Cell Cycle Nucleoplasm Nucleus Regulation Of Protein Modification Process Intracellular Signal Transduction Negative Regulation Of Cell Cycle Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Negative Regulation Of Macromolecule Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA Replication Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Positive Regulation Of DNA Replication Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Modification Process Signal Transduction In Response To DNA Damage Regulation Of Phosphorus Metabolic Process Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Phosphorylation Positive Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Cell Division DNA Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of DNA Metabolic Process Cyclin Binding Regulation Of Kinase Activity DNA Damage Response Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process
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