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ARHGEF6 and PARVB
Number of citations of the paper that reports this interaction (PubMedID
12499396
)
0
Data Source:
HPRD
(two hybrid, in vitro)
ARHGEF6
PARVB
Description
Rac/Cdc42 guanine nucleotide exchange factor 6
parvin beta
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Cell-cell Junction
Lamellipodium
Cell Projection
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Focal Adhesion
Actin Cytoskeleton
Membrane
Sarcomere
Z Disc
Lamellipodium
Cell Projection
Anchoring Junction
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Protein Binding
Actin Binding
Protein Binding
Biological Process
Apoptotic Process
JNK Cascade
Lamellipodium Assembly
Cell Adhesion
Cell Projection Assembly
Lamellipodium Assembly
Actin Cytoskeleton Organization
Substrate Adhesion-dependent Cell Spreading
Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape
Plasma Membrane Bounded Cell Projection Assembly
Pathways
NRAGE signals death through JNK
G alpha (12/13) signalling events
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
G beta:gamma signalling through CDC42
CDC42 GTPase cycle
RAC1 GTPase cycle
RHOU GTPase cycle
Cell-extracellular matrix interactions
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs
Diseases
Non-syndromic X-linked mental retardation
GWAS
Autism spectrum disorder (
34069769
)
Breast cancer (
29059683
)
Alzheimer's disease (cognitive decline) (
23535033
)
Hematological and biochemical traits (
20139978
)
Lewy body disease (
25188341
)
Monocyte count (
32888494
)
Nonalcoholic fatty liver disease (
22719876
)
Pediatric non-alcoholic fatty liver disease activity score (
23535911
)
Response to chemotherapy in breast cancer (hypertension) (bevacizumab) (
25117820
)
Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) (
25117820
)
Systemic sclerosis (anti-centromere-positive) (
29293537
)
Interacting Genes
36 interacting genes:
ADAM15
ARAP3
ARHGEF7
BMPR1B
CAPNS1
CBFA2T3
CCDC33
CDC42
EPHB2
GIT1
GOLGA2
GPRASP2
HSF2BP
KRT27
NUTM1
PAK1
PAK2
PAK3
PARVB
PNMA1
POU6F2
RWDD2A
SH2D1A
SH3GL3
SIRPA
SMAD1
SMAD2
SMAD3
TGFBR1
TGFBR2
TMEM108
TP53BP2
TRAF2
TRIM54
YWHAG
ZNF580
3 interacting genes:
ARHGEF6
ILK
PCNT
Entrez ID
9459
29780
HPRD ID
02226
16284
Ensembl ID
ENSG00000129675
ENSG00000188677
Uniprot IDs
B7Z3C7
Q15052
Q8N4Q3
A0A087WZB5
Q9HBI1
PDB IDs
1UJY
1WYR
4EDL
4EDM
4EDN
Enriched GO Terms of Interacting Partners
?
Enzyme-linked Receptor Protein Signaling Pathway
Response To Growth Factor
Dendritic Spine Development
I-SMAD Binding
Cellular Response To Growth Factor Stimulus
Regulation Of Cytoskeleton Organization
Regulation Of Supramolecular Fiber Organization
Ephrin Receptor Signaling Pathway
SMAD Protein Signal Transduction
SMAD Protein Complex
Trophoblast Cell Migration
Heteromeric SMAD Protein Complex
Embryonic Cranial Skeleton Morphogenesis
Activin Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Regulation Of Stress Fiber Assembly
Co-SMAD Binding
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Primary MiRNA Processing
Transforming Growth Factor Beta Receptor Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
SMAD Binding
Protein Kinase Binding
Homomeric SMAD Protein Complex
Positive Regulation Of Stress Fiber Assembly
Regulation Of Actin Cytoskeleton Organization
Dendritic Spine Morphogenesis
Positive Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Microtubule Nucleation
Protein Kinase Activity
Positive Regulation Of Actin Filament Bundle Assembly
Cellular Response To Lectin
Stimulatory C-type Lectin Receptor Signaling Pathway
Paraxial Mesoderm Morphogenesis
Transforming Growth Factor Beta Ligand-receptor Complex
Regulation Of Actin Filament-based Process
Response To Transforming Growth Factor Beta
Immune System Process
Regulation Of Cartilage Development
Protein Serine/threonine Kinase Activity
Regulation Of Cellular Component Organization
Positive Regulation Of Cell Migration
Regulation Of Actin Filament Organization
Response To Cholesterol
Roof Of Mouth Development
Response To Stress
Positive Regulation Of Cell Motility
Regulation Of Organelle Organization
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Spindle Organization
Mitotic Spindle Organization
Cell Projection Organization
Microtubule Cytoskeleton Organization Involved In Mitosis
Lamellipodium
Protein Localization To Cell Cortex
Plasma Membrane Bounded Cell Projection Assembly
Cell Projection Assembly
Plasma Membrane Raft Assembly
Schwann Cell Development
Microtubule Cytoskeleton Organization
Membrane Raft Assembly
Plasma Membrane Raft Organization
Caveola Assembly
Cellular Component Assembly
Fibroblast Migration
Myelination In Peripheral Nervous System
Centrosome
Membrane Raft Organization
Negative Regulation Of Neural Precursor Cell Proliferation
Microtubule Nucleation
Branching Involved In Ureteric Bud Morphogenesis
Regulation Of Substrate Adhesion-dependent Cell Spreading
Membrane Assembly
Tumor Necrosis Factor-mediated Signaling Pathway
Nerve Development
Intracellular Signaling Cassette
Cytoskeleton Organization
Establishment Or Maintenance Of Apical/basal Cell Polarity
Platelet Aggregation
Outflow Tract Morphogenesis
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Sarcomere
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Substrate Adhesion-dependent Cell Spreading
Microtubule-based Process
Positive Regulation Of BMP Signaling Pathway
Plasma Membrane Bounded Cell Projection Organization
Lamellipodium Assembly
Lamellipodium Organization
JNK Cascade
Glial Cell Development
Homotypic Cell-cell Adhesion
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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