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ARHGEF6
Gene Name
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
Image
Gene Ontology Annotations
Cellular Component
Intracellular
Cytosol
Cell-cell Junction
Lamellipodium
Molecular Function
Rho Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Protein Binding
Biological Process
Apoptotic Process
JNK Cascade
Small GTPase Mediated Signal Transduction
Lamellipodium Assembly
Positive Regulation Of Rho GTPase Activity
Cell Junction Assembly
Positive Regulation Of Apoptotic Process
Positive Regulation Of GTPase Activity
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Small GTPase Mediated Signal Transduction
Apoptotic Signaling Pathway
Pathways
Signaling by GPCR
Cell junction organization
Signalling by NGF
Cell death signalling via NRAGE, NRIF and NADE
p75 NTR receptor-mediated signalling
Rho GTPase cycle
GPCR downstream signaling
NRAGE signals death through JNK
Signaling by Rho GTPases
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
G alpha (12/13) signalling events
Cell-extracellular matrix interactions
Drugs
Diseases
GWAS
Protein-protein Interactions
22 interactors:
ADAM15
ARHGEF7
BMPR1B
CAPNS1
CDC42
EPHB2
GIT1
GPRASP2
PAK1
PAK2
PAK3
PARVB
SH2D1A
SH3GL3
SMAD1
SMAD2
SMAD3
TGFBR1
TGFBR2
TMEM108
YWHAG
ZNF580
Entrez ID
9459
HPRD ID
02226
Ensembl ID
ENSG00000129675
Uniprot IDs
B7Z3C7
Q15052
Q8N4Q3
PDB IDs
1UJY
1WYR
Enriched GO Terms of Interacting Partners
?
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Cell Morphogenesis
Cell Morphogenesis Involved In Differentiation
Ephrin Receptor Signaling Pathway
Cell Development
Intracellular Signal Transduction
Anatomical Structure Morphogenesis
Axon Guidance
Chemotaxis
Signal Transduction By Phosphorylation
Positive Regulation Of Cell Morphogenesis Involved In Differentiation
Cell Differentiation
Nervous System Development
System Development
Cell Morphogenesis
Axonogenesis
Primary MiRNA Processing
Regulation Of Cellular Component Organization
Axon Development
Generation Of Neurons
Positive Regulation Of Cell Differentiation
Regulation Of Cell Development
Regulation Of Signaling
Regulation Of Cell Differentiation
Positive Regulation Of Cell Adhesion
Positive Regulation Of Apoptotic Process
Cell Morphogenesis Involved In Neuron Differentiation
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Programmed Cell Death
SMAD Protein Complex Assembly
Positive Regulation Of Cell Death
Regulation Of Cell Adhesion
Neurogenesis
Locomotion
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Signal Transduction
Neuron Projection Morphogenesis
Multicellular Organismal Development
Signaling
Regulation Of Signal Transduction
Cell Communication
Anatomical Structure Development
Response To External Stimulus
Transforming Growth Factor Beta Receptor Signaling Pathway
Growth
Positive Regulation Of Cell Development
Regulation Of Cell Proliferation
Heart Development
Embryonic Cranial Skeleton Morphogenesis
Signal Transduction
Tagcloud
?
acted
analyzing
bioinformatic
constructed
crc
dataset
david
degs
disturbed
downloaded
fzd2
gse23878
hprd
hub
intend
jup
kegg
module
modules
networks
omnibus
pdgfrb
prkcb
student
theses
uncovered
wnt11
wnt2
wnt5a