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TGFBR2 and STRAP
Number of citations of the paper that reports this interaction (PubMedID
9856985
)
0
Data Source:
HPRD
(in vivo, two hybrid, in vitro)
TGFBR2
STRAP
Description
transforming growth factor beta receptor 2
serine/threonine kinase receptor associated protein
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytosol
Plasma Membrane
Caveola
External Side Of Plasma Membrane
Cell Surface
Membrane
Nuclear Body
Receptor Complex
Membrane Raft
Activin Receptor Complex
Transforming Growth Factor Beta Ligand-receptor Complex
Nucleus
Cytoplasm
Cytosol
SMN Complex
SMN-Sm Protein Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Activity
Transforming Growth Factor Beta Receptor Activity, Type II
Protein Binding
ATP Binding
Glycosaminoglycan Binding
Kinase Activity
Activin Receptor Activity, Type I
Transferase Activity
Kinase Activator Activity
Type I Transforming Growth Factor Beta Receptor Binding
Type III Transforming Growth Factor Beta Receptor Binding
Signaling Receptor Activity
SMAD Binding
Metal Ion Binding
Activin Binding
Transforming Growth Factor Beta Binding
Molecular Adaptor Activity
RNA Binding
MRNA Binding
Signaling Receptor Binding
Protein Binding
U2 SnRNP Binding
Biological Process
Blood Vessel Development
Branching Involved In Blood Vessel Morphogenesis
Vasculogenesis
In Utero Embryonic Development
Epithelial To Mesenchymal Transition
Heart Looping
Positive Regulation Of Mesenchymal Cell Proliferation
Lens Development In Camera-type Eye
Positive Regulation Of Tolerance Induction To Self Antigen
Positive Regulation Of B Cell Tolerance Induction
Positive Regulation Of T Cell Tolerance Induction
Outflow Tract Septum Morphogenesis
Membranous Septum Morphogenesis
Outflow Tract Morphogenesis
Aortic Valve Morphogenesis
Atrioventricular Valve Morphogenesis
Tricuspid Valve Morphogenesis
Cardiac Left Ventricle Morphogenesis
Endocardial Cushion Fusion
Growth Plate Cartilage Development
Growth Plate Cartilage Chondrocyte Growth
Apoptotic Process
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Notch Signaling Pathway
Smoothened Signaling Pathway
Gastrulation
Nervous System Development
Brain Development
Heart Development
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Epithelial To Mesenchymal Transition
Cell Differentiation
Lung Development
Activin Receptor Signaling Pathway
Response To Lipid
Embryonic Hemopoiesis
Aorta Morphogenesis
Regulation Of Cell Population Proliferation
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Angiogenesis
Animal Organ Development
Blood Vessel Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Artery Morphogenesis
Positive Regulation Of Developmental Process
Positive Regulation Of NK T Cell Differentiation
Cartilage Development
Regulation Of Multicellular Organismal Process
Roof Of Mouth Development
Positive Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Lung Morphogenesis
Bronchus Development
Bronchus Morphogenesis
Trachea Morphogenesis
Trachea Formation
Mammary Gland Morphogenesis
Lung Lobe Morphogenesis
Langerhans Cell Differentiation
Secondary Palate Development
Response To Cholesterol
Cellular Response To Growth Factor Stimulus
Regulation Of Stem Cell Proliferation
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Cell Proliferation Involved In Endocardial Cushion Morphogenesis
Superior Endocardial Cushion Morphogenesis
Inferior Endocardial Cushion Morphogenesis
Lens Fiber Cell Apoptotic Process
MiRNA Transport
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Regulation Of Stem Cell Differentiation
Negative Regulation Of Transcription By RNA Polymerase II
Alternative MRNA Splicing, Via Spliceosome
Spliceosomal SnRNP Assembly
MRNA Splicing, Via Spliceosome
MRNA Processing
RNA Splicing
Protein-RNA Complex Assembly
Neuron Differentiation
Maintenance Of Gastrointestinal Epithelium
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Pathways
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
UCH proteinases
TGFBR3 regulates TGF-beta signaling
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
Positive Regulation of CDH1 Gene Transcription
Drugs
Foreskin fibroblast (neonatal)
Foreskin keratinocyte (neonatal)
Fostamatinib
Diseases
Loeys-Dietz syndrome (LDS)
Colorectal cancer
Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS
Breast cancer (
23535729
29059683
)
Cellular nuclear factor (erythroid-derived 2)-like 2 levels (
30767168
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
Estimated glomerular filtration rate (
31152163
)
Heel bone mineral density (
30598549
)
Metabolite levels (
23823483
)
Migraine (
22683712
27322543
)
Migraine - clinic-based (
23793025
)
Night sleep phenotypes (
27126917
)
Postprandial triglyceride response (
32603185
)
Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) (
25117820
)
Systolic blood pressure (
30224653
)
Tonometry (
17903302
)
Interacting Genes
51 interacting genes:
ACVR1
ACVRL1
AP2B1
APP
ARHGEF6
ARHGEF7
CCNB1
CCNB2
CD44
CDK1
CLU
CRIPTO
CTNNB1
DAB2
DAXX
DYNLT4
EIF3I
ENG
FANCC
GOPC
KCNK18
MAP2K1
NRP1
OSR1
PAK1
PDGFRA
PIK3R1
PIK3R2
PML
PPP2CB
PSMD14
RCVRN
SMAD3
SMAD4
SMAD7
SNX6
STRAP
TERT
TGFB1
TGFB1I1
TGFB2
TGFB3
TGFBR1
TGFBR3
TGFBRAP1
TRAP1
TRMO
TSSK1B
USP8
ZFYVE9
ZNF510
31 interacting genes:
ANXA1
CEBPA
CHEK2
FOXP1
GEMIN6
GEMIN7
MAP1B
MTRES1
NEIL3
NXF1
PBLD
PDPK1
PTEN
RN7SL1
RNU1-1
RNU2-1
SMAD2
SMAD3
SMAD6
SMAD7
SMN1
SMURF1
SNRPB
SNRPD2
SNRPD3
SNRPE
SUMO2
SUMO4
SZRD1
TGFBR1
TGFBR2
Entrez ID
7048
11171
HPRD ID
01823
05816
Ensembl ID
ENSG00000163513
ENSG00000023734
Uniprot IDs
A0AAQ5BI06
A3QNQ0
D2JYI1
P37173
Q9Y3F4
PDB IDs
1KTZ
1M9Z
1PLO
2PJY
3KFD
4P7U
4XJJ
5E8V
5E8Y
5E91
5E92
5QIN
5TX4
5TY4
7DV6
8G4K
8YGZ
9B9F
9E9G
9FDY
9FK5
9FKP
Enriched GO Terms of Interacting Partners
?
Transforming Growth Factor Beta Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cellular Response To Growth Factor Stimulus
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of SMAD Protein Signal Transduction
Response To Growth Factor
Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
SMAD Binding
Regulation Of Apoptotic Process
Tissue Morphogenesis
Heart Development
Regulation Of Programmed Cell Death
Positive Regulation Of Developmental Process
Cell Surface Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Type II Transforming Growth Factor Beta Receptor Binding
Regulation Of Signal Transduction
Tube Morphogenesis
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Transforming Growth Factor Beta Receptor Binding
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Anatomical Structure Morphogenesis
I-SMAD Binding
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Cell Motility
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Locomotion
Regulation Of Developmental Process
Regulation Of Growth
Regulation Of Cell Differentiation
Embryo Development Ending In Birth Or Egg Hatching
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Migration
Multicellular Organism Development
Regulation Of Cellular Component Organization
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Cell Differentiation
Transforming Growth Factor Beta Binding
Mesenchymal Cell Differentiation
SMN-Sm Protein Complex
I-SMAD Binding
Spliceosomal SnRNP Assembly
Spliceosomal Complex Assembly
Heteromeric SMAD Protein Complex
7-methylguanosine Cap Hypermethylation
SMAD Protein Signal Transduction
U2 SnRNP
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Protein-RNA Complex Assembly
Type I Transforming Growth Factor Beta Receptor Binding
U4 SnRNP
Response To Growth Factor
Methylosome
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Small Nuclear Ribonucleoprotein Complex
Cellular Response To Growth Factor Stimulus
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
U1 SnRNP
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
U5 SnRNP
Regulation Of Epithelial To Mesenchymal Transition
RNA Splicing, Via Transesterification Reactions
Activin Receptor Binding
U2-type Prespliceosome Assembly
U12-type Spliceosomal Complex
PICln-Sm Protein Complex
Nucleoplasm
R-SMAD Binding
Regulation Of SMAD Protein Signal Transduction
Trophoblast Cell Migration
U7 SnRNP
U2-type Spliceosomal Complex
Embryonic Cranial Skeleton Morphogenesis
Activin Receptor Signaling Pathway
U2-type Catalytic Step 2 Spliceosome
U4/U6 X U5 Tri-snRNP Complex
Ureteric Bud Development
SMN Complex
Ubiquitin Protein Ligase Binding
Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Ossification
Co-SMAD Binding
Gemini Of Cajal Bodies
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
MRNA Splicing, Via Spliceosome
Mesonephric Tubule Development
Mesonephric Epithelium Development
SMAD Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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