Wiki-Pi
About
Search
People
Updates
Search
TGFBR2 and PAK1
Number of citations of the paper that reports this interaction (PubMedID
15761153
)
0
Data Source:
BioGRID
(pull down, affinity chromatography technology)
HPRD
(in vivo)
TGFBR2
PAK1
Description
transforming growth factor beta receptor 2
p21 (RAC1) activated kinase 1
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytosol
Plasma Membrane
Caveola
External Side Of Plasma Membrane
Cell Surface
Membrane
Nuclear Body
Receptor Complex
Membrane Raft
Activin Receptor Complex
Transforming Growth Factor Beta Ligand-receptor Complex
Ruffle
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Intercalated Disc
Membrane
Z Disc
Lamellipodium
Axon
Dendrite
Nuclear Membrane
Ruffle Membrane
Protein-containing Complex
Cell Projection
Anchoring Junction
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Activity
Transforming Growth Factor Beta Receptor Activity, Type II
Protein Binding
ATP Binding
Glycosaminoglycan Binding
Kinase Activity
Activin Receptor Activity, Type I
Transferase Activity
Kinase Activator Activity
Type I Transforming Growth Factor Beta Receptor Binding
Type III Transforming Growth Factor Beta Receptor Binding
Signaling Receptor Activity
SMAD Binding
Metal Ion Binding
Activin Binding
Transforming Growth Factor Beta Binding
Molecular Adaptor Activity
Nucleotide Binding
Catalytic Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
Collagen Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Small GTPase Binding
Identical Protein Binding
Gamma-tubulin Binding
Protein Serine Kinase Activity
Biological Process
Blood Vessel Development
Branching Involved In Blood Vessel Morphogenesis
Vasculogenesis
In Utero Embryonic Development
Epithelial To Mesenchymal Transition
Heart Looping
Positive Regulation Of Mesenchymal Cell Proliferation
Lens Development In Camera-type Eye
Positive Regulation Of Tolerance Induction To Self Antigen
Positive Regulation Of B Cell Tolerance Induction
Positive Regulation Of T Cell Tolerance Induction
Outflow Tract Septum Morphogenesis
Membranous Septum Morphogenesis
Outflow Tract Morphogenesis
Aortic Valve Morphogenesis
Atrioventricular Valve Morphogenesis
Tricuspid Valve Morphogenesis
Cardiac Left Ventricle Morphogenesis
Endocardial Cushion Fusion
Growth Plate Cartilage Development
Growth Plate Cartilage Chondrocyte Growth
Apoptotic Process
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Notch Signaling Pathway
Smoothened Signaling Pathway
Gastrulation
Nervous System Development
Brain Development
Heart Development
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Epithelial To Mesenchymal Transition
Cell Differentiation
Lung Development
Activin Receptor Signaling Pathway
Response To Lipid
Embryonic Hemopoiesis
Aorta Morphogenesis
Regulation Of Cell Population Proliferation
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Angiogenesis
Animal Organ Development
Blood Vessel Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Artery Morphogenesis
Positive Regulation Of Developmental Process
Positive Regulation Of NK T Cell Differentiation
Cartilage Development
Regulation Of Multicellular Organismal Process
Roof Of Mouth Development
Positive Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Lung Morphogenesis
Bronchus Development
Bronchus Morphogenesis
Trachea Morphogenesis
Trachea Formation
Mammary Gland Morphogenesis
Lung Lobe Morphogenesis
Langerhans Cell Differentiation
Secondary Palate Development
Response To Cholesterol
Cellular Response To Growth Factor Stimulus
Regulation Of Stem Cell Proliferation
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Cell Proliferation Involved In Endocardial Cushion Morphogenesis
Superior Endocardial Cushion Morphogenesis
Inferior Endocardial Cushion Morphogenesis
Lens Fiber Cell Apoptotic Process
MiRNA Transport
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Regulation Of Stem Cell Differentiation
MAPK Cascade
Response To Hypoxia
Stimulatory C-type Lectin Receptor Signaling Pathway
Chromatin Remodeling
Exocytosis
Apoptotic Process
DNA Damage Response
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Cellular Response To Starvation
Positive Regulation Of Fibroblast Migration
Cell Migration
Cerebellum Development
Establishment Of Cell Polarity
Actin Cytoskeleton Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Microtubule Polymerization
Cellular Response To Insulin Stimulus
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Intracellular Signal Transduction
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Wound Healing
Regulation Of MAPK Cascade
Positive Regulation Of Axon Extension
Positive Regulation Of Insulin Receptor Signaling Pathway
Hepatocyte Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Branching Morphogenesis Of An Epithelial Tube
Neuron Projection Morphogenesis
Regulation Of Axonogenesis
Positive Regulation Of Stress Fiber Assembly
Negative Regulation Of Cell Proliferation Involved In Contact Inhibition
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Positive Regulation Of Microtubule Nucleation
Positive Regulation Of Protein Targeting To Membrane
Regulation Of Actin Filament Organization
Protein Localization To Cytoplasmic Stress Granule
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
UCH proteinases
TGFBR3 regulates TGF-beta signaling
Generation of second messenger molecules
Regulation of actin dynamics for phagocytic cup formation
FCERI mediated MAPK activation
FCERI mediated MAPK activation
CD28 dependent Vav1 pathway
EPHB-mediated forward signaling
Ephrin signaling
Sema3A PAK dependent Axon repulsion
Activation of RAC1
Signal transduction by L1
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PKNs
RHO GTPases Activate ROCKs
RHO GTPases activate PAKs
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling
G beta:gamma signalling through CDC42
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOQ GTPase cycle
RHOH GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
Drugs
Foreskin fibroblast (neonatal)
Foreskin keratinocyte (neonatal)
Fostamatinib
Fostamatinib
Diseases
Loeys-Dietz syndrome (LDS)
Colorectal cancer
Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS
Breast cancer (
23535729
29059683
)
Cellular nuclear factor (erythroid-derived 2)-like 2 levels (
30767168
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
Estimated glomerular filtration rate (
31152163
)
Heel bone mineral density (
30598549
)
Metabolite levels (
23823483
)
Migraine (
22683712
27322543
)
Migraine - clinic-based (
23793025
)
Night sleep phenotypes (
27126917
)
Postprandial triglyceride response (
32603185
)
Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) (
25117820
)
Systolic blood pressure (
30224653
)
Tonometry (
17903302
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Tourette syndrome (
30818990
)
Interacting Genes
51 interacting genes:
ACVR1
ACVRL1
AP2B1
APP
ARHGEF6
ARHGEF7
CCNB1
CCNB2
CD44
CDK1
CLU
CRIPTO
CTNNB1
DAB2
DAXX
DYNLT4
EIF3I
ENG
FANCC
GOPC
KCNK18
MAP2K1
NRP1
OSR1
PAK1
PDGFRA
PIK3R1
PIK3R2
PML
PPP2CB
PSMD14
RCVRN
SMAD3
SMAD4
SMAD7
SNX6
STRAP
TERT
TGFB1
TGFB1I1
TGFB2
TGFB3
TGFBR1
TGFBR3
TGFBRAP1
TRAP1
TRMO
TSSK1B
USP8
ZFYVE9
ZNF510
89 interacting genes:
ABI3
ACTA1
ACVR1
AKT1
APP
ARHGEF2
ARHGEF6
ARHGEF7
ARPC1B
BAD
BAIAP2
BCL6
BMPR1B
BMX
BRSK1
BTG3
CASP1
CDC42
CDK11B
CDK5
CDK5R1
CHORDC1
COL1A1
CPLANE1
CSNK2A1
CSNK2A2
DSCAM
DSCR9
DYNLL1
DYNLL2
DYRK1B
EGFR
ELF3
ERBB2
ESR1
FLNA
FOXL2
FOXO1
FRS2
GIT2
GRB2
H3C1
H4C1
HACE1
HGS
HSP90AA1
KEAP1
LIMK1
MAP2K1
MAP3K1
MAPK1
MBP
MYLK
MYNN
MYO6
NCK1
NCK2
NF2
OXSR1
PAK1IP1
PDPK1
PLCG1
PPM1A
PPM1F
PPP1CA
PPP2CA
PRKCD
PXN
RAC1
RAF1
RHOJ
RHOU
SHC1
SMAD1
SMAD2
SMAD4
SMURF1
SORBS2
SYN1
TGFBR1
TGFBR2
TGM2
YWHAG
YWHAZ
ZBTB18
ZC3H7A
ZNF418
ZNF823
ZNF83
Entrez ID
7048
5058
HPRD ID
01823
03995
Ensembl ID
ENSG00000163513
ENSG00000149269
Uniprot IDs
A0AAQ5BI06
A3QNQ0
D2JYI1
P37173
B3KNX7
E9PM17
Q13153
PDB IDs
1KTZ
1M9Z
1PLO
2PJY
3KFD
4P7U
4XJJ
5E8V
5E8Y
5E91
5E92
5QIN
5TX4
5TY4
7DV6
8G4K
8YGZ
9B9F
9E9G
9FDY
9FK5
9FKP
1F3M
1YHV
1YHW
1ZSG
2HY8
2QME
3DVP
3FXZ
3FY0
3Q4Z
3Q52
3Q53
4DAW
4EQC
4O0R
4O0T
4P90
4ZJI
4ZJJ
4ZLO
4ZY4
4ZY5
4ZY6
5DEW
5DEY
5DFP
5IME
5KBQ
5KBR
6B16
7VTO
8X5Z
Enriched GO Terms of Interacting Partners
?
Transforming Growth Factor Beta Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cellular Response To Growth Factor Stimulus
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of SMAD Protein Signal Transduction
Response To Growth Factor
Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
SMAD Binding
Regulation Of Apoptotic Process
Tissue Morphogenesis
Heart Development
Regulation Of Programmed Cell Death
Positive Regulation Of Developmental Process
Cell Surface Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Type II Transforming Growth Factor Beta Receptor Binding
Regulation Of Signal Transduction
Tube Morphogenesis
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Transforming Growth Factor Beta Receptor Binding
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Anatomical Structure Morphogenesis
I-SMAD Binding
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Cell Motility
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Locomotion
Regulation Of Developmental Process
Regulation Of Growth
Regulation Of Cell Differentiation
Embryo Development Ending In Birth Or Egg Hatching
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Migration
Multicellular Organism Development
Regulation Of Cellular Component Organization
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Cell Differentiation
Transforming Growth Factor Beta Binding
Mesenchymal Cell Differentiation
Enzyme-linked Receptor Protein Signaling Pathway
Intracellular Signal Transduction
Protein Kinase Activity
Cell Surface Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Signal Transduction
Intracellular Signaling Cassette
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Developmental Process
Kinase Activity
Protein Serine/threonine Kinase Activity
Regulation Of Multicellular Organismal Process
Response To Growth Factor
Regulation Of Signal Transduction
Anatomical Structure Morphogenesis
Regulation Of Supramolecular Fiber Organization
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cellular Component Organization
Protein Phosphorylation
ERBB Signaling Pathway
Positive Regulation Of Supramolecular Fiber Organization
Positive Regulation Of Locomotion
Focal Adhesion
Regulation Of Cell Differentiation
Regulation Of Intracellular Signal Transduction
Lamellipodium
Phosphorylation
Regulation Of Anatomical Structure Morphogenesis
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Motility
Protein Kinase Binding
Regulation Of Locomotion
Cytosol
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Cell Motility
Positive Regulation Of Cell Migration
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Cytoskeleton Organization
Regulation Of Cell Migration
Developmental Process
Regulation Of Cytoskeleton Organization
Positive Regulation Of Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Cell Adhesion
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Protein Localization
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?