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TGFBR2 and PIK3R2
Number of citations of the paper that reports this interaction (PubMedID
9435577
)
0
Data Source:
HPRD
(in vivo)
TGFBR2
PIK3R2
Description
transforming growth factor beta receptor 2
phosphoinositide-3-kinase regulatory subunit 2
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytosol
Plasma Membrane
Caveola
External Side Of Plasma Membrane
Cell Surface
Membrane
Nuclear Body
Receptor Complex
Membrane Raft
Activin Receptor Complex
Transforming Growth Factor Beta Ligand-receptor Complex
Nucleus
Cytosol
Focal Adhesion
Phosphatidylinositol 3-kinase Complex, Class IA
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Activity
Transforming Growth Factor Beta Receptor Activity, Type II
Protein Binding
ATP Binding
Glycosaminoglycan Binding
Kinase Activity
Activin Receptor Activity, Type I
Transferase Activity
Kinase Activator Activity
Type I Transforming Growth Factor Beta Receptor Binding
Type III Transforming Growth Factor Beta Receptor Binding
Signaling Receptor Activity
SMAD Binding
Metal Ion Binding
Activin Binding
Transforming Growth Factor Beta Binding
Molecular Adaptor Activity
Phosphotyrosine Residue Binding
GTPase Activator Activity
Protein Binding
Protein Phosphatase Binding
Receptor Tyrosine Kinase Binding
Phosphatidylinositol 3-kinase Regulatory Subunit Binding
1-phosphatidylinositol-3-kinase Regulator Activity
Protein Heterodimerization Activity
Biological Process
Blood Vessel Development
Branching Involved In Blood Vessel Morphogenesis
Vasculogenesis
In Utero Embryonic Development
Epithelial To Mesenchymal Transition
Heart Looping
Positive Regulation Of Mesenchymal Cell Proliferation
Lens Development In Camera-type Eye
Positive Regulation Of Tolerance Induction To Self Antigen
Positive Regulation Of B Cell Tolerance Induction
Positive Regulation Of T Cell Tolerance Induction
Outflow Tract Septum Morphogenesis
Membranous Septum Morphogenesis
Outflow Tract Morphogenesis
Aortic Valve Morphogenesis
Atrioventricular Valve Morphogenesis
Tricuspid Valve Morphogenesis
Cardiac Left Ventricle Morphogenesis
Endocardial Cushion Fusion
Growth Plate Cartilage Development
Growth Plate Cartilage Chondrocyte Growth
Apoptotic Process
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Notch Signaling Pathway
Smoothened Signaling Pathway
Gastrulation
Nervous System Development
Brain Development
Heart Development
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Epithelial To Mesenchymal Transition
Cell Differentiation
Lung Development
Activin Receptor Signaling Pathway
Response To Lipid
Embryonic Hemopoiesis
Aorta Morphogenesis
Regulation Of Cell Population Proliferation
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Angiogenesis
Animal Organ Development
Blood Vessel Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Artery Morphogenesis
Positive Regulation Of Developmental Process
Positive Regulation Of NK T Cell Differentiation
Cartilage Development
Regulation Of Multicellular Organismal Process
Roof Of Mouth Development
Positive Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Lung Morphogenesis
Bronchus Development
Bronchus Morphogenesis
Trachea Morphogenesis
Trachea Formation
Mammary Gland Morphogenesis
Lung Lobe Morphogenesis
Langerhans Cell Differentiation
Secondary Palate Development
Response To Cholesterol
Cellular Response To Growth Factor Stimulus
Regulation Of Stem Cell Proliferation
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Cell Proliferation Involved In Endocardial Cushion Morphogenesis
Superior Endocardial Cushion Morphogenesis
Inferior Endocardial Cushion Morphogenesis
Lens Fiber Cell Apoptotic Process
MiRNA Transport
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Regulation Of Stem Cell Differentiation
Intracellular Glucose Homeostasis
Immune Response
Signal Transduction
Insulin Receptor Signaling Pathway
Regulation Of Autophagy
Protein Transport
B Cell Differentiation
T Cell Differentiation
Regulation Of Actin Filament Polymerization
Cellular Response To Insulin Stimulus
Response To Endoplasmic Reticulum Stress
Positive Regulation Of Protein Import Into Nucleus
Negative Regulation Of MAPK Cascade
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Adhesion
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Stress Fiber Assembly
Regulation Of Protein Localization To Plasma Membrane
Pathways
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
UCH proteinases
TGFBR3 regulates TGF-beta signaling
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
Downstream signal transduction
PI3K/AKT activation
Signaling by ALK
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
RHOA GTPase cycle
Extra-nuclear estrogen signaling
RHOB GTPase cycle
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOD GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOF GTPase cycle
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
RND3 GTPase cycle
RND2 GTPase cycle
RND1 GTPase cycle
Signaling by ALK fusions and activated point mutants
Signaling by LTK in cancer
Signaling by LTK
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Co-stimulation by ICOS
Drugs
Foreskin fibroblast (neonatal)
Foreskin keratinocyte (neonatal)
Fostamatinib
SF1126
Diseases
Loeys-Dietz syndrome (LDS)
Colorectal cancer
Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS
Breast cancer (
23535729
29059683
)
Cellular nuclear factor (erythroid-derived 2)-like 2 levels (
30767168
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
Estimated glomerular filtration rate (
31152163
)
Heel bone mineral density (
30598549
)
Metabolite levels (
23823483
)
Migraine (
22683712
27322543
)
Migraine - clinic-based (
23793025
)
Night sleep phenotypes (
27126917
)
Postprandial triglyceride response (
32603185
)
Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) (
25117820
)
Systolic blood pressure (
30224653
)
Tonometry (
17903302
)
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Mental health study participation (completed survey) (
31263887
)
Interacting Genes
51 interacting genes:
ACVR1
ACVRL1
AP2B1
APP
ARHGEF6
ARHGEF7
CCNB1
CCNB2
CD44
CDK1
CLU
CRIPTO
CTNNB1
DAB2
DAXX
DYNLT4
EIF3I
ENG
FANCC
GOPC
KCNK18
MAP2K1
NRP1
OSR1
PAK1
PDGFRA
PIK3R1
PIK3R2
PML
PPP2CB
PSMD14
RCVRN
SMAD3
SMAD4
SMAD7
SNX6
STRAP
TERT
TGFB1
TGFB1I1
TGFB2
TGFB3
TGFBR1
TGFBR3
TGFBRAP1
TRAP1
TRMO
TSSK1B
USP8
ZFYVE9
ZNF510
60 interacting genes:
APP
APPL1
AR
ARRB1
AXL
CBL
CD28
CRK
CRKL
CSF1R
DYDC1
EGF
EGFR
ENKUR
EPHA2
ERBB2
ERBB3
ERBB4
FBXL2
FGFR1
FYN
GAB1
GHR
GOLGA2
GRB2
GRN
HCK
IGF1R
IKZF3
IRS1
IRS2
KIT
KRAS
KRT15
KRT20
KRT38
LAMB2
LMNA
LTBP3
MET
MRFAP1L1
PDGFRB
PIK3CB
PIK3CD
RINT1
SEPTIN2
SHC1
SOCS1
SOCS6
SOCS7
SOS1
STAB1
STAT3
SYK
TEC
TGFBR1
TGFBR2
TRIM23
WASF3
YWHAB
Entrez ID
7048
5296
HPRD ID
01823
04404
Ensembl ID
ENSG00000163513
ENSG00000105647
Uniprot IDs
A0AAQ5BI06
A3QNQ0
D2JYI1
P37173
O00459
PDB IDs
1KTZ
1M9Z
1PLO
2PJY
3KFD
4P7U
4XJJ
5E8V
5E8Y
5E91
5E92
5QIN
5TX4
5TY4
7DV6
8G4K
8YGZ
9B9F
9E9G
9FDY
9FK5
9FKP
2KT1
2XS6
3MTT
3O5Z
6OX7
6U28
7RCH
7RNU
Enriched GO Terms of Interacting Partners
?
Transforming Growth Factor Beta Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cellular Response To Growth Factor Stimulus
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of SMAD Protein Signal Transduction
Response To Growth Factor
Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
SMAD Binding
Regulation Of Apoptotic Process
Tissue Morphogenesis
Heart Development
Regulation Of Programmed Cell Death
Positive Regulation Of Developmental Process
Cell Surface Receptor Signaling Pathway
Regulation Of Cell Population Proliferation
Type II Transforming Growth Factor Beta Receptor Binding
Regulation Of Signal Transduction
Tube Morphogenesis
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Transforming Growth Factor Beta Receptor Binding
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Anatomical Structure Morphogenesis
I-SMAD Binding
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Cell Motility
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Locomotion
Regulation Of Developmental Process
Regulation Of Growth
Regulation Of Cell Differentiation
Embryo Development Ending In Birth Or Egg Hatching
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Migration
Multicellular Organism Development
Regulation Of Cellular Component Organization
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Cell Differentiation
Transforming Growth Factor Beta Binding
Mesenchymal Cell Differentiation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Protein Tyrosine Kinase Activity
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Signal Transduction
Receptor Complex
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Population Proliferation
Transmembrane Receptor Protein Tyrosine Kinase Activity
Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Multicellular Organismal Process
Regulation Of Cell Migration
Regulation Of Cell Motility
Intracellular Signal Transduction
Positive Regulation Of Cell Migration
Regulation Of Cell Population Proliferation
Regulation Of Developmental Process
Regulation Of MAPK Cascade
Positive Regulation Of Cell Motility
Regulation Of Locomotion
Positive Regulation Of Locomotion
Kinase Activity
Positive Regulation Of MAPK Cascade
Protein Kinase Activity
Developmental Process
Peptidyl-tyrosine Phosphorylation
Response To Growth Factor
Positive Regulation Of Multicellular Organismal Process
Insulin-like Growth Factor Receptor Signaling Pathway
Cellular Developmental Process
Cellular Response To Growth Factor Stimulus
Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Programmed Cell Death
Regulation Of Multicellular Organismal Development
Cell Population Proliferation
Growth Factor Binding
Positive Regulation Of Epithelial Cell Proliferation
Phosphotyrosine Residue Binding
Regulation Of Programmed Cell Death
Morphogenesis Of An Epithelium
ERBB Signaling Pathway
Tissue Morphogenesis
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Tagcloud (Intersection)
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