ARHGEF6 and ADAM15

Number of citations of the paper that reports this interaction (PMID 16374509)
26

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		ARHGEF6	ADAM15
Gene Name		Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	ADAM metallopeptidase domain 15
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Cytosol Cell-cell Junction Lamellipodium	Acrosomal Vesicle Plasma Membrane Adherens Junction Cell Surface Integral Component Of Membrane Cell Projection Extracellular Vesicular Exosome
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding
	Biological Process	Apoptotic Process JNK Cascade Small GTPase Mediated Signal Transduction Lamellipodium Assembly Positive Regulation Of Rho GTPase Activity Cell Junction Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Angiogenesis Negative Regulation Of Cell-matrix Adhesion Proteolysis Apoptotic Process Cell-matrix Adhesion Integrin-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Collagen Catabolic Process Tissue Regeneration Innate Immune Response Cardiac Epithelial To Mesenchymal Transition Protein Kinase C Signaling Negative Regulation Of Receptor Binding
Pathways		Signaling by GPCR Cell junction organization Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G alpha (12/13) signalling events Cell-extracellular matrix interactions	Degradation of the extracellular matrix
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		22 interactors: ADAM15 ARHGEF7 BMPR1B CAPNS1 CDC42 EPHB2 GIT1 GPRASP2 PAK1 PAK2 PAK3 PARVB SH2D1A SH3GL3 SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 YWHAG ZNF580	32 interactors: ABL1 ARHGEF6 ARHGEF7 BANP FHL3 FYN GRB2 HCK LCK LYN MAD2L2 NCK1 NPHP1 NUP62 PACSIN3 RBPMS SH3D19 SH3GL2 SH3GLB1 SH3PXD2A SH3RF1 SH3RF3 SNX30 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SP4 SRC TRIP13 YES1
Entrez ID		9459	8751
HPRD ID		02226	05674
Ensembl ID		ENSG00000129675	ENSG00000143537
Uniprot IDs		B7Z3C7 Q15052 Q8N4Q3	B4DMH8 Q13444 U3KQL5
PDB IDs		1UJY 1WYR
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Morphogenesis Cell Morphogenesis Involved In Differentiation Ephrin Receptor Signaling Pathway Cell Development Intracellular Signal Transduction Anatomical Structure Morphogenesis Axon Guidance Chemotaxis Signal Transduction By Phosphorylation Positive Regulation Of Cell Morphogenesis Involved In Differentiation Cell Differentiation Nervous System Development System Development Cell Morphogenesis Axonogenesis Primary MiRNA Processing Regulation Of Cellular Component Organization Axon Development Generation Of Neurons Positive Regulation Of Cell Differentiation Regulation Of Cell Development Regulation Of Signaling Regulation Of Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Apoptotic Process Cell Morphogenesis Involved In Neuron Differentiation Cell Surface Receptor Signaling Pathway Positive Regulation Of Programmed Cell Death SMAD Protein Complex Assembly Positive Regulation Of Cell Death Regulation Of Cell Adhesion Neurogenesis Locomotion Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Neuron Projection Morphogenesis Multicellular Organismal Development Signaling Regulation Of Signal Transduction Cell Communication Anatomical Structure Development Response To External Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Growth Positive Regulation Of Cell Development Regulation Of Cell Proliferation Heart Development Embryonic Cranial Skeleton Morphogenesis Signal Transduction	Peptidyl-tyrosine Autophosphorylation Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Costimulation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Axon Guidance Phagocytosis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Metabolic Process Membrane Tubulation Regulation Of Endocytosis Regulation Of Cell Adhesion Cellular Response To Peptide Hormone Stimulus Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Cellular Response To Peptide Positive Regulation Of Cellular Protein Metabolic Process Protein Autophosphorylation Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Neurotrophin Signaling Pathway Leukocyte Migration Axonogenesis Positive Regulation Of Cell Adhesion Regulation Of Vesicle-mediated Transport Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Locomotion Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Cell-cell Adhesion Axon Development Cellular Response To Hormone Stimulus Regulation Of Phosphorylation Cell Morphogenesis Involved In Neuron Differentiation Actin Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		acted analyzing bioinformatic constructed crc dataset david degs disturbed downloaded fzd2 gse23878 hprd hub intend jup kegg module modules networks omnibus pdgfrb prkcb student theses uncovered wnt11 wnt2 wnt5a	adams alkaline alp apparently appeared catenin compartment cytoplasm deposition disintegrin effectors homeostasis immunoreactivity jun lesser metalloprotease mineralization nodule osteoblast osteoblasts osteoclasts phosphatase prominently skeletal taking thickness trabecular unaffected undergo
Tagcloud (Difference) ?		acted analyzing bioinformatic constructed crc dataset david degs disturbed downloaded fzd2 gse23878 hprd hub intend jup kegg module modules networks omnibus pdgfrb prkcb student theses uncovered wnt11 wnt2 wnt5a	adams alkaline alp apparently appeared catenin compartment cytoplasm deposition disintegrin effectors homeostasis immunoreactivity jun lesser metalloprotease mineralization nodule osteoblast osteoblasts osteoclasts phosphatase prominently skeletal taking thickness trabecular unaffected undergo
Tagcloud (Intersection) ?