TGFBR2 and MAP2K1

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		TGFBR2	MAP2K1
Description		transforming growth factor beta receptor 2	mitogen-activated protein kinase kinase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane Caveola External Side Of Plasma Membrane Cell Surface Membrane Nuclear Body Receptor Complex Membrane Raft Activin Receptor Complex Transforming Growth Factor Beta Ligand-receptor Complex	Nucleus Cytoplasm Mitochondrion Early Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Focal Adhesion Cell Cortex Postsynaptic Density Membrane Axon Dendrite Dendrite Cytoplasm Ciliary Basal Body Perikaryon Perinuclear Region Of Cytoplasm Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type II Protein Binding ATP Binding Glycosaminoglycan Binding Kinase Activity Activin Receptor Activity, Type I Transferase Activity Kinase Activator Activity Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Signaling Receptor Activity SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding Molecular Adaptor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Kinase Activator Activity Small GTPase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Serine/threonine Kinase Activator Activity Protein-containing Complex Binding Scaffold Protein Binding Protein Serine Kinase Activity
	Biological Process	Blood Vessel Development Branching Involved In Blood Vessel Morphogenesis Vasculogenesis In Utero Embryonic Development Epithelial To Mesenchymal Transition Heart Looping Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Positive Regulation Of Tolerance Induction To Self Antigen Positive Regulation Of B Cell Tolerance Induction Positive Regulation Of T Cell Tolerance Induction Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Outflow Tract Morphogenesis Aortic Valve Morphogenesis Atrioventricular Valve Morphogenesis Tricuspid Valve Morphogenesis Cardiac Left Ventricle Morphogenesis Endocardial Cushion Fusion Growth Plate Cartilage Development Growth Plate Cartilage Chondrocyte Growth Apoptotic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Smoothened Signaling Pathway Gastrulation Nervous System Development Brain Development Heart Development Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Cell Differentiation Lung Development Activin Receptor Signaling Pathway Response To Lipid Embryonic Hemopoiesis Aorta Morphogenesis Regulation Of Cell Population Proliferation Myeloid Dendritic Cell Differentiation Positive Regulation Of Angiogenesis Animal Organ Development Blood Vessel Morphogenesis Embryonic Cranial Skeleton Morphogenesis Artery Morphogenesis Positive Regulation Of Developmental Process Positive Regulation Of NK T Cell Differentiation Cartilage Development Regulation Of Multicellular Organismal Process Roof Of Mouth Development Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Lung Morphogenesis Bronchus Development Bronchus Morphogenesis Trachea Morphogenesis Trachea Formation Mammary Gland Morphogenesis Lung Lobe Morphogenesis Langerhans Cell Differentiation Secondary Palate Development Response To Cholesterol Cellular Response To Growth Factor Stimulus Regulation Of Stem Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cell Proliferation Involved In Endocardial Cushion Morphogenesis Superior Endocardial Cushion Morphogenesis Inferior Endocardial Cushion Morphogenesis Lens Fiber Cell Apoptotic Process MiRNA Transport Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Regulation Of Stem Cell Differentiation	MAPK Cascade Regulation Of Vascular Associated Smooth Muscle Contraction Chemotaxis Response To Oxidative Stress Signal Transduction Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Schwann Cell Development Cerebellar Cortex Formation Central Nervous System Neuron Differentiation Neuron Differentiation Keratinocyte Differentiation Positive Regulation Of Cell Migration Thyroid Gland Development Melanosome Transport Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Homotypic Cell-cell Adhesion Endodermal Cell Differentiation ERBB2-ERBB3 Signaling Pathway Myelination Positive Regulation Of MAPK Cascade Type B Pancreatic Cell Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Muscle Contraction Positive Regulation Of Ras Protein Signal Transduction Vesicle Transport Along Microtubule Insulin-like Growth Factor Receptor Signaling Pathway Golgi Inheritance Thymus Development Response To Axon Injury Regulation Of Axon Regeneration Neuron Projection Morphogenesis Cell Motility Positive Regulation Of Axonogenesis Response To Glucocorticoid Bergmann Glial Cell Differentiation Face Development Lung Morphogenesis Trachea Formation Epithelial Cell Proliferation Involved In Lung Morphogenesis Placenta Blood Vessel Development Labyrinthine Layer Development Triglyceride Homeostasis ERK1 And ERK2 Cascade Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Golgi Inheritance Cellular Senescence Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Endodermal Cell Differentiation Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of ATP Biosynthetic Process
Pathways		Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer UCH proteinases TGFBR3 regulates TGF-beta signaling	MAPK3 (ERK1) activation Frs2-mediated activation Signal transduction by L1 Uptake and function of anthrax toxins RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway MAP3K8 (TPL2)-dependent MAPK1/3 activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by MAP2K mutants Signaling by RAF1 mutants
Drugs		Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Fostamatinib	K-252a 5-Bromo-N-[(2S)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide Cobimetinib Bosutinib (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide Mirdametinib N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE Trametinib Selumetinib Pimasertib
Diseases		Loeys-Dietz syndrome (LDS) Colorectal cancer Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)	Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Breast cancer ( 23535729 29059683) Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168) Cognitive decline rate in late mild cognitive impairment ( 26252872) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Migraine ( 22683712 27322543) Migraine - clinic-based ( 23793025) Night sleep phenotypes ( 27126917) Postprandial triglyceride response ( 32603185) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Systolic blood pressure ( 30224653) Tonometry ( 17903302)	Prostate cancer ( 29892016) Testicular germ cell tumor ( 28604728 28604732)
Interacting Genes		51 interacting genes: ACVR1 ACVRL1 AP2B1 APP ARHGEF6 ARHGEF7 CCNB1 CCNB2 CD44 CDK1 CLU CRIPTO CTNNB1 DAB2 DAXX DYNLT4 EIF3I ENG FANCC GOPC KCNK18 MAP2K1 NRP1 OSR1 PAK1 PDGFRA PIK3R1 PIK3R2 PML PPP2CB PSMD14 RCVRN SMAD3 SMAD4 SMAD7 SNX6 STRAP TERT TGFB1 TGFB1I1 TGFB2 TGFB3 TGFBR1 TGFBR3 TGFBRAP1 TRAP1 TRMO TSSK1B USP8 ZFYVE9 ZNF510	67 interacting genes: APC ARAF AURKA BANP BAX BIRC6 BMPR1A BRAF BUB1 CASP9 CDH1 CDK5 CDKN2A CPNE1 CPNE4 CTNNA1 EGFR ELK1 EP300 ERBB2 FBXW7 GRB10 HNRNPD HRAS ITCH KAT7 KSR1 KSR2 LAMTOR3 MAP3K4 MAP3K8 MAPK1 MAPK14 MAPK3 MAPK8 MAPK8IP3 MBP MLH3 MSH6 MYC ODC1 PAK1 PARVA PDGFRL PEBP1 PEBP4 PIK3CA PLEKHF2 PLK3 PPARG PRKCI PRKCZ PTPRJ RAF1 RPS6KA2 RPS6KA4 SMAD2 SRC STK11 TCP11 TGFBR2 TLR2 TRAF3 TRAF6 TRIB1 UBE2I WNK1
Entrez ID		7048	5604
HPRD ID		01823	01469
Ensembl ID		ENSG00000163513	ENSG00000169032
Uniprot IDs		A0AAQ5BI06 A3QNQ0 D2JYI1 P37173	A0A8I5KYS7 A4QPA9 B4DFY5 Q02750
PDB IDs		1KTZ 1M9Z 1PLO 2PJY 3KFD 4P7U 4XJJ 5E8V 5E8Y 5E91 5E92 5QIN 5TX4 5TY4 7DV6 8G4K 8YGZ 9B9F 9E9G 9FDY 9FK5 9FKP	1S9J 2P55 3DV3 3DY7 3E8N 3EQB 3EQC 3EQD 3EQF 3EQG 3EQH 3EQI 3MBL 3ORN 3OS3 3PP1 3SLS 3V01 3V04 3VVH 3W8Q 3WIG 3ZLS 3ZLW 3ZLX 3ZLY 3ZM4 4AN2 4AN3 4AN9 4ANB 4ARK 4LMN 4MNE 4U7Z 4U80 4U81 5BX0 5EYM 5HZE 5YT3 6NYB 6PP9 6Q0J 6Q0T 6U2G 6V2W 6X2P 6X2S 6X2X 7B3M 7B7R 7B94 7B9L 7F2X 7M0T 7M0U 7M0V 7M0W 7M0X 7M0Y 7M0Z 7MFD 7PQV 7UMB 7XLP 7XNC 8CHF 8DGS 8DGT 8YP4 9AXA 9AXC 9AXH 9AXM 9AXX 9AXY 9AY7 9AYA
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Response To Growth Factor Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Binding Regulation Of Apoptotic Process Tissue Morphogenesis Heart Development Regulation Of Programmed Cell Death Positive Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Regulation Of Cell Population Proliferation Type II Transforming Growth Factor Beta Receptor Binding Regulation Of Signal Transduction Tube Morphogenesis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Cell Migration Positive Regulation Of Cell Communication Positive Regulation Of Signaling Anatomical Structure Morphogenesis I-SMAD Binding Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Cell Motility Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Locomotion Regulation Of Developmental Process Regulation Of Growth Regulation Of Cell Differentiation Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Cell Population Proliferation Regulation Of Cell Migration Multicellular Organism Development Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Differentiation Transforming Growth Factor Beta Binding Mesenchymal Cell Differentiation	Intracellular Signal Transduction Protein Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Protein Serine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction MAPK Cascade ATP Binding Regulation Of Cell Communication Regulation Of Signaling Transferase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Apoptotic Process Signal Transduction Regulation Of MAPK Cascade Programmed Cell Death Cell Death Intracellular Signaling Cassette Nucleotide Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Regulation Of Multicellular Organismal Process Cytosol Regulation Of Cellular Localization Regulation Of Cell Population Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Localization Regulation Of Protein Modification Process Protein Phosphorylation Positive Regulation Of Macromolecule Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Animal Organ Development Regulation Of Cell Differentiation Phosphorylation Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Cellular Component Organization Regulation Of Cell Development Enzyme-linked Receptor Protein Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Macromolecule Metabolic Process Regulation Of Phosphorylation Immune Response-activating Signaling Pathway
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