HOMER2 and KPNA2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		HOMER2	KPNA2
Description		homer scaffold protein 2	karyopherin subunit alpha 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Dendrite Stereocilium Stereocilium Tip Cell Projection Intracellular Organelle Apical Part Of Cell Synapse Glutamatergic Synapse	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Nuclear Membrane NLS-dependent Protein Nuclear Import Complex Host Cell
	Molecular Function	Actin Binding Protein Binding Synaptic Receptor Adaptor Activity G Protein-coupled Glutamate Receptor Binding	RNA Binding Protein Binding Nuclear Localization Sequence Binding Histone Deacetylase Binding Nuclear Import Signal Receptor Activity
	Biological Process	G Protein-coupled Glutamate Receptor Signaling Pathway Sensory Perception Of Sound Regulation Of G Protein-coupled Receptor Signaling Pathway Calcium-mediated Signaling Negative Regulation Of Interleukin-2 Production Behavioral Response To Cocaine Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Store-operated Calcium Entry	Regulation Of DNA Recombination DNA Metabolic Process Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Protein Transport Positive Regulation Of Type I Interferon Production Non-canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-templated Transcription Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Viral Life Cycle
Pathways		Neurexins and neuroligins Neurexins and neuroligins	CaMK IV-mediated phosphorylation of CREB ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Sensing of DNA Double Strand Breaks Estrogen-dependent gene expression SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Bipolar disorder ( 34002096) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Tourette syndrome ( 30818990)	Brain morphology (MOSTest) ( 32665545) Feeling lonely ( 29500382) General risk tolerance (MTAG) ( 30643258) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889)
Interacting Genes		14 interacting genes: ABI3 AGAP2 APP DBN1 FXR1 GRM1 ITPR1 KPNA2 LZTS2 PJA1 RYR1 SMURF1 UBXN1 VKORC1	111 interacting genes: ACTN1 ACTN4 ANKIB1 AP2B1 APOBEC1 APP ARL4A ARL5A ATXN3 BAG6 BRCA1 BTBD2 CASP2 CCDC107 CDA CDC42 CDK5RAP3 CHD3 CHEK2 CORO1B CREB3L3 CREBBP CSNK1A1 CUL4B DCPS DCTN2 DDIT3 EIF4ENIF1 EP300 EPB41 FEZ2 FN1 FTH1 GART GMCL1 GRB2 GTF2IRD1 H1-0 HAP1 HMG20A HNRNPC HOMER2 HOMEZ HSPA4 IFT20 IMMT INO80E ITK JUN KLC4 KPNB1 KRT18 KRT40 KRT8 LAMB2 LEF1 LZTS2 MAGED1 MAGEH1 MDFI MLH1 MORC3 MORF4L1 MVP NECAB2 NFE2L2 NFKBIB NMNAT1 NR3C1 NUP153 NUP50 NUP62 NUTM1 OGT PAX5 PLAG1 PNMA5 PRKD3 PTMA RAG1 RANBP2 RBM48 RBPMS RECQL RELA RELB RGL2 RILP RNMT SERTAD3 SGK1 SLC2A2 SPRY1 SRPK1 STUB1 SUMO2 TADA2A TAF3 TAF8 TANK TBPL2 TP53 TRAF1 TRIM54 TSC22D4 TXNIP UBR5 USHBP1 ZBTB7B ZC3H12A ZNF131
Entrez ID		9455	3838
HPRD ID		07269	02818
Ensembl ID		ENSG00000103942	ENSG00000182481
Uniprot IDs		Q9NSB8	P52292
PDB IDs			1EFX 1QGK 1QGR 3FEX 3FEY 3WPT 4E4V 4WV6 5H43 7CRU 7N8J 7N9H 8FZK 8GCN
Enriched GO Terms of Interacting Partners?		Regulation Of Neuronal Synaptic Plasticity Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Intracellularly Gated Calcium Channel Activity Negative Regulation Of Long-term Synaptic Potentiation Postsynaptic Density Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Protein Tetramerization Neuron Projection Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Dendritic Shaft Monoatomic Ion Homeostasis Glutamate Receptor Signaling Pathway Protein Homooligomerization Growth Cone Lamellipodium Intracellular Monoatomic Cation Homeostasis Postsynapse Regulation Of Long-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Regulation Of Synaptic Plasticity Calcium-mediated Signaling Dendrite Amylin Binding Inorganic Ion Homeostasis Negative Regulation Of Protein Localization Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Regulation Of Postsynapse Organization Cellular Localization Monoatomic Cation Homeostasis Intracellular Chemical Homeostasis Cytoplasm Intracellular Monoatomic Ion Homeostasis Ligand-gated Ion Channel Signaling Pathway Dendritic Spine Positive Regulation Of Neurogenesis Regulation Of Dendritic Spine Morphogenesis Intracellular Calcium Ion Homeostasis Calcium Ion Homeostasis G Protein-coupled Receptor Homodimeric Complex G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels Engulfment Of Target By Autophagosome Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Primary Ureteric Bud Growth Glutamatergic Synapse Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion	Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Identical Protein Binding Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Chromatin Organization Regulation Of Programmed Cell Death Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin Protein Ligase Binding Intracellular Signal Transduction DNA Damage Response Cytoplasm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Signal Transduction Negative Regulation Of Biosynthetic Process Cytosol Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Intracellular Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Protein Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Nuclear Inclusion Body Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus
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