HOMER2 and AGAP2

Number of citations of the paper that reports this interaction (PubMedID 14528310)
0

Data Source:
HPRD (in vivo, in vitro)

		HOMER2	AGAP2
Description		homer scaffold protein 2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Dendrite Stereocilium Stereocilium Tip Cell Projection Intracellular Organelle Apical Part Of Cell Synapse Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Membrane Extracellular Exosome Flemming Body
	Molecular Function	Actin Binding Protein Binding Synaptic Receptor Adaptor Activity G Protein-coupled Glutamate Receptor Binding	Nucleotide Binding GTPase Activity GTPase Activator Activity Protein Binding ATP Binding GTP Binding Zinc Ion Binding Protein Kinase Binding Protein Kinase Activator Activity Phosphatidylinositol 3-kinase Regulator Activity Metal Ion Binding Phosphatidylinositol 3-kinase Activator Activity
	Biological Process	G Protein-coupled Glutamate Receptor Signaling Pathway Sensory Perception Of Sound Regulation Of G Protein-coupled Receptor Signaling Pathway Calcium-mediated Signaling Negative Regulation Of Interleukin-2 Production Behavioral Response To Cocaine Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Store-operated Calcium Entry	Protein Transport Endosomal Transport Actin Cytoskeleton Organization Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Kinase Activity
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Netrin-1 signaling
Drugs
Diseases
GWAS		Bipolar disorder ( 34002096) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Tourette syndrome ( 30818990)	Heel bone mineral density ( 30598549) Multiple sclerosis ( 21833088)
Interacting Genes		14 interacting genes: ABI3 AGAP2 APP DBN1 FXR1 GRM1 ITPR1 KPNA2 LZTS2 PJA1 RYR1 SMURF1 UBXN1 VKORC1	16 interacting genes: AKT1 ARF1 BTG3 CDC42 CDK4 EPB41L1 GRIP1 HOMER1 HOMER2 NF2 PIK3R1 PLCG1 PRKAA1 RAC1 RAC2 RHOA
Entrez ID		9455	116986
HPRD ID		07269	05687
Ensembl ID		ENSG00000103942	ENSG00000135439
Uniprot IDs		Q9NSB8	Q99490
PDB IDs			2BMJ 2IWR 2RLO
Enriched GO Terms of Interacting Partners?		Regulation Of Neuronal Synaptic Plasticity Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Intracellularly Gated Calcium Channel Activity Negative Regulation Of Long-term Synaptic Potentiation Postsynaptic Density Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Protein Tetramerization Neuron Projection Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Dendritic Shaft Monoatomic Ion Homeostasis Glutamate Receptor Signaling Pathway Protein Homooligomerization Growth Cone Lamellipodium Intracellular Monoatomic Cation Homeostasis Postsynapse Regulation Of Long-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Regulation Of Synaptic Plasticity Calcium-mediated Signaling Dendrite Amylin Binding Inorganic Ion Homeostasis Negative Regulation Of Protein Localization Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Regulation Of Postsynapse Organization Cellular Localization Monoatomic Cation Homeostasis Intracellular Chemical Homeostasis Cytoplasm Intracellular Monoatomic Ion Homeostasis Ligand-gated Ion Channel Signaling Pathway Dendritic Spine Positive Regulation Of Neurogenesis Regulation Of Dendritic Spine Morphogenesis Intracellular Calcium Ion Homeostasis Calcium Ion Homeostasis G Protein-coupled Receptor Homodimeric Complex G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels Engulfment Of Target By Autophagosome Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Primary Ureteric Bud Growth Glutamatergic Synapse Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion	Intracellular Signaling Cassette Intracellular Signal Transduction Lamellipodium Regulation Of Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Lamellipodium Assembly Regulation Of Transport Regulation Of Stress Fiber Assembly Positive Regulation Of Lamellipodium Organization Regulation Of Actin Filament-based Process Regulation Of Cell-substrate Adhesion Regulation Of Lamellipodium Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Cell Projection Organization Cytosol Membrane Invagination Regulation Of Actin Filament Organization Dendrite Regulation Of Lamellipodium Organization Positive Regulation Of Stress Fiber Assembly Cytoplasm Positive Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Adhesion Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Vesicle-mediated Transport Regulation Of Organelle Organization Positive Regulation Of Cell Migration Regulation Of Cell Population Proliferation Positive Regulation Of Cell Motility Positive Regulation Of Cell Projection Organization Cell Projection Actin Cytoskeleton Organization Positive Regulation Of Locomotion Signal Transduction Regulation Of Supramolecular Fiber Organization Apical Part Of Cell Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Migration Actin Filament-based Process Regulation Of Leukocyte Migration Positive Regulation Of Immune System Process Postsynapse Regulation Of Cell Projection Assembly Regulation Of Cell Motility Ruffle Membrane G Protein-coupled Glutamate Receptor Binding Regulation Of Cellular Component Organization Protein Kinase Binding Regulation Of Locomotion
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