HOMER2 and AGAP2

Number of citations of the paper that reports this interaction (PMID 14528310)
65

Data Source:
HPRD (in vitro, in vivo)

		HOMER2	AGAP2
Gene Name		homer homolog 2 (Drosophila)	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane Cell Junction Dendrite Neuronal Cell Body Apical Part Of Cell Postsynaptic Membrane Neuronal Postsynaptic Density	Nucleus Nucleolus Mitochondrion Membrane Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Protein Domain Specific Binding GKAP/Homer Scaffold Activity G-protein Coupled Glutamate Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Protein Binding GTP Binding ARF GTPase Activator Activity Zinc Ion Binding
	Biological Process	G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Calcium-mediated Signaling Using Intracellular Calcium Source Behavioral Response To Cocaine Chemical Homeostasis Within A Tissue Regulation Of Store-operated Calcium Entry	Small GTPase Mediated Signal Transduction Axon Guidance Protein Transport Regulation Of ARF GTPase Activity Negative Regulation Of Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity
Pathways			Axon guidance Netrin-1 signaling
Drugs
Diseases
GWAS			Multiple sclerosis ( 21833088)
Protein-Protein Interactions		11 interactors: AGAP2 APP DBN1 GRM1 ITPR1 KPNA2 LZTS2 RNF41 RYR1 UBXN1 VKORC1	6 interactors: EPB41L1 HOMER1 HOMER2 NF2 PIK3R1 PLCG1
Entrez ID		9455	116986
HPRD ID		07269	05687
Ensembl ID		ENSG00000103942	ENSG00000135439
Uniprot IDs		Q9NSB8	F8VVT9 Q99490
PDB IDs			2BMJ 2IWR 2RLO
Enriched GO Terms of Interacting Partners?		Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Endoplasmic Reticulum Calcium Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Signaling Regulation Of Sequestering Of Calcium Ion Cytoplasmic Transport Calcium Ion Transport Into Cytosol Cellular Homeostasis Cytosolic Calcium Ion Transport Cellular Localization Intracellular Transport Glutamate Receptor Signaling Pathway Chemical Homeostasis Dimeric G-protein Coupled Receptor Signaling Pathway Regulation Of Signal Transduction Blood Coagulation Hemostasis Cell Communication Synaptic Growth At Neuromuscular Junction Response To Abiotic Stimulus Establishment Of Localization In Cell Cell Surface Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Collateral Sprouting In Absence Of Injury Cell Communication By Chemical Coupling Response To Stimulus Voluntary Musculoskeletal Movement Multicellular Organismal Development Regulation Of Body Fluid Levels Regulation Of Phosphorylation Collateral Sprouting Axon Midline Choice Point Recognition Wound Healing Cellular Response To Stimulus Regulation Of Ion Homeostasis Homeostatic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Vitamin K Metabolic Process Regulation Of Phosphorus Metabolic Process	Chemical Homeostasis Within A Tissue Behavioral Response To Cocaine Regulation Of Store-operated Calcium Entry G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of Calcium Ion Transport Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell-substrate Adhesion Response To Cocaine Glutamate Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Calcium Ion Transport Response To Ammonium Ion Calcium-mediated Signaling NFAT Protein Import Into Nucleus Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Migration T Cell Receptor Signaling Pathway Regulation Of Ion Transport Regulation Of Cell Motility Regulation Of Cell-matrix Adhesion Regulation Of Locomotion Regulation Of Cellular Component Movement Transcription Factor Import Into Nucleus Phospholipase C-activating G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of Protein Stability Antigen Receptor-mediated Signaling Pathway Second-messenger-mediated Signaling Positive Regulation Of Transport Response To Alkaloid Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Adult Behavior Response To Organonitrogen Compound Tissue Homeostasis Chemical Homeostasis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Cell-substrate Adhesion Regulation Of Protein Localization To Nucleus Positive Regulation Of Ion Transport Negative Regulation Of Cell Adhesion Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein
Tagcloud ?		accumbens activational addictive arguing aversion behaviorally blunt cci constriction cpa cpp heroin incentive intrathecal limbic mesolimbic mglur5 motivational neuroadaptations psychopharmacology uninjured
Tagcloud (Difference) ?		accumbens activational addictive arguing aversion behaviorally blunt cci constriction cpa cpp heroin incentive intrathecal limbic mesolimbic mglur5 motivational neuroadaptations psychopharmacology uninjured
Tagcloud (Intersection) ?