HOMER2 and ITPR1

Number of citations of the paper that reports this interaction (PMID 9808459)
116

Data Source:
HPRD (in vitro, in vivo)

		HOMER2	ITPR1
Gene Name		homer homolog 2 (Drosophila)	inositol 1,4,5-trisphosphate receptor, type 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane Cell Junction Dendrite Neuronal Cell Body Apical Part Of Cell Postsynaptic Membrane Neuronal Postsynaptic Density	Nuclear Inner Membrane Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Calcineurin Complex Postsynaptic Density Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Platelet Dense Granule Membrane Platelet Dense Tubular Network Platelet Dense Tubular Network Membrane
	Molecular Function	Actin Binding Protein Domain Specific Binding GKAP/Homer Scaffold Activity G-protein Coupled Glutamate Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Intracellular Ligand-gated Calcium Channel Activity Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Binding Calcium Ion Transmembrane Transporter Activity Calcium Channel Inhibitor Activity Phosphatidylinositol Binding
	Biological Process	G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Calcium-mediated Signaling Using Intracellular Calcium Source Behavioral Response To Cocaine Chemical Homeostasis Within A Tissue Regulation Of Store-operated Calcium Entry	Response To Hypoxia Energy Reserve Metabolic Process Calcium Ion Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Post-embryonic Development Platelet Activation Endoplasmic Reticulum Calcium Ion Homeostasis Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Negative Regulation Of Calcium-mediated Signaling Voluntary Musculoskeletal Movement Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Phospholipase C-mediated cascade Signaling by FGFR in disease Integration of energy metabolism cGMP effects Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Effects of PIP2 hydrolysis Platelet calcium homeostasis DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Platelet homeostasis Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Platelet activation, signaling and aggregation Adaptive Immune System G alpha (q) signalling events DAG and IP3 signaling VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Nitric oxide stimulates guanylate cyclase Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF PLC beta mediated events Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by FGFR Ca2+ pathway Elevation of cytosolic Ca2+ levels PLC-gamma1 signalling FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS			Airflow obstruction ( 22837378) Breast cancer ( 23535729) Obesity-related traits ( 23251661)
Protein-Protein Interactions		11 interactors: AGAP2 APP DBN1 GRM1 ITPR1 KPNA2 LZTS2 RNF41 RYR1 UBXN1 VKORC1	29 interactors: AHCYL1 AKT1 ARHGAP1 BANK1 BCL2 CA8 CABP1 CCNB1 CDK1 EPB41L1 ERP44 FKBP1A FYN GRM1 HOMER1 HOMER2 HOMER3 ITPR3 ITPRIP LYN MRVI1 PRKACA PRKCD PRKG1 RHOA RYR2 STARD13 TRPC3 TRPC4
Entrez ID		9455	3708
HPRD ID		07269	00925
Ensembl ID		ENSG00000103942	ENSG00000150995
Uniprot IDs		Q9NSB8	B4DER3 B4DGH1 Q14643 Q59H91
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Endoplasmic Reticulum Calcium Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Signaling Regulation Of Sequestering Of Calcium Ion Cytoplasmic Transport Calcium Ion Transport Into Cytosol Cellular Homeostasis Cytosolic Calcium Ion Transport Cellular Localization Intracellular Transport Glutamate Receptor Signaling Pathway Chemical Homeostasis Dimeric G-protein Coupled Receptor Signaling Pathway Regulation Of Signal Transduction Blood Coagulation Hemostasis Cell Communication Synaptic Growth At Neuromuscular Junction Response To Abiotic Stimulus Establishment Of Localization In Cell Cell Surface Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Collateral Sprouting In Absence Of Injury Cell Communication By Chemical Coupling Response To Stimulus Voluntary Musculoskeletal Movement Multicellular Organismal Development Regulation Of Body Fluid Levels Regulation Of Phosphorylation Collateral Sprouting Axon Midline Choice Point Recognition Wound Healing Cellular Response To Stimulus Regulation Of Ion Homeostasis Homeostatic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Vitamin K Metabolic Process Regulation Of Phosphorus Metabolic Process	Regulation Of Calcium Ion Transport Regulation Of Ion Transport Response To Wounding Vascular Endothelial Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Protein Localization Blood Coagulation Hemostasis Regulation Of Cellular Localization Wound Healing Platelet Activation Cell Activation Regulation Of Transmembrane Transporter Activity Positive Regulation Of Signal Transduction Regulation Of Body Fluid Levels Response To Organonitrogen Compound Regulation Of Intracellular Transport Signaling Regulation Of Platelet Aggregation Cell Communication Response To Organic Substance Response To Organic Cyclic Compound Response To Metal Ion Cellular Response To Stimulus Signal Transduction Neurotrophin TRK Receptor Signaling Pathway G-protein Coupled Glutamate Receptor Signaling Pathway Positive Regulation Of Transport Neurotrophin Signaling Pathway Regulation Of Catalytic Activity Second-messenger-mediated Signaling Regulation Of Ion Transmembrane Transporter Activity Regulation Of Intracellular Signal Transduction Response To Stimulus Regulation Of Ion Homeostasis Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Platelet Activation Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Cell Activation Regulation Of Establishment Of Protein Localization Response To Inorganic Substance Positive Regulation Of Catalytic Activity Regulation Of Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor
Tagcloud ?		accumbens activational addictive arguing aversion behaviorally blunt cci constriction cpa cpp heroin incentive intrathecal limbic mesolimbic mglur5 motivational neuroadaptations psychopharmacology uninjured	autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Difference) ?		accumbens activational addictive arguing aversion behaviorally blunt cci constriction cpa cpp heroin incentive intrathecal limbic mesolimbic mglur5 motivational neuroadaptations psychopharmacology uninjured	autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Intersection) ?