ZFYVE9 and ATP6V0B

Data Source: HiPPIP (Novel)

		ZFYVE9	ATP6V0B
Name		zinc finger FYVE-type containing 9	ATPase H+ transporting V0 subunit b
Structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Membrane Early Endosome Membrane Protein-containing Complex	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Membrane Endosome Plasma Membrane Endosome Membrane Membrane Clathrin-coated Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Proton-transporting V-type ATPase, V0 Domain
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Zinc Ion Binding Protein Domain Specific Binding Metal Ion Binding	Protein Binding Proton Transmembrane Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway Endosomal Transport	Monoatomic Ion Transport Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Macroautophagy Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Proton Transmembrane Transport
Pathways		None	ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs		None	Tiludronic acid
GWAS		Hip circumference adjusted for BMI ( 34021172 )	Autism spectrum disorder or schizophrenia ( 28540026 )
Novel Interactors		2 novel interactors: ATP6V0B NRDC	6 novel interactors: BPI CCL19 DAPK2 RPS26P15 TTC39A ZFYVE9
Interacting Genes		38 interacting genes: ANKLE2 BAG6 BMP4 CHD6 CLTC CTNNB1 DAZAP2 EIF4G1 ERBIN ETS2 FHL2 JUP LRP12 NIT1 NUP155 PML PPP1CA PPP1CB PPP1CC PPP2R1A RBBP6 RHOT2 RNF11 RNPEP SCYL2 SMAD2 SMAD3 SPART ST7 SUMF2 SUPT5H SVEP1 TENT5A TGFBR1 TGFBR2 UBC UBXN11 ZMYND8	28 interacting genes: ADGRG3 ADRB2 APOD COL4A5 EMP1 FAM210B FAS GJA8 GPR42 GPR61 INSIG2 IRAK3 KLRC1 MFF MIP MS4A3 MTNR1B NRM SLC10A1 SLC2A5 SNTA1 SPACA1 STOM TM4SF19 TMEM242 VMA21 YWHAE YWHAG
Entrez ID		9372	533
HPRD ID		04782	04759
Ensembl ID		ENSG00000157077	ENSG00000117410
Uniprot IDs		O95405	E9PNL3 Q99437
PDB IDs		1DEV 1MK2 4BKW 5MJY	6WLW 6WM2 6WM3 6WM4 7U4T 7UNF
GO Terms Enriched among Interactors		Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Ubiquitin Protein Ligase Binding Embryonic Skeletal System Morphogenesis I-SMAD Binding SMAD Binding Lung Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Skeletal System Morphogenesis Entrainment Of Circadian Clock By Photoperiod Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Signal Transduction Trachea Formation Trophoblast Cell Migration PTW/PP1 Phosphatase Complex Embryonic Organ Morphogenesis Photoperiodism Entrainment Of Circadian Clock Activin Receptor Signaling Pathway Embryonic Foregut Morphogenesis Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Cell Fate Commitment Tissue Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Tissue Development Gastrulation Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Branching Involved In Lung Morphogenesis Tube Morphogenesis Positive Regulation Of Developmental Process Regulation Of Chondrocyte Differentiation Positive Regulation Of Transcription Elongation By RNA Polymerase II Mesenchyme Development Regulation Of Developmental Process Formation Of Primary Germ Layer Branching Morphogenesis Of An Epithelial Tube Osteoblast Differentiation Bronchus Development Animal Organ Formation Positive Regulation Of DNA-templated Transcription, Elongation Catenin-TCF7L2 Complex Paraxial Mesoderm Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Regulation Of Translation In Response To Stress Circadian Regulation Of Gene Expression In Utero Embryonic Development Regulation Of SMAD Protein Signal Transduction Developmental Growth	Membrane Specific Granule Membrane Gap Junction-mediated Intercellular Transport Protein Sequestering Activity Intercellular Transport