ZFYVE9 and TGFBR2

Number of citations of the paper that reports this interaction (PubMedID 9865696)
0

Data Source:
HPRD (in vivo)

		ZFYVE9	TGFBR2
Description		zinc finger FYVE-type containing 9	transforming growth factor beta receptor 2
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Membrane Early Endosome Membrane Protein-containing Complex	Extracellular Region Extracellular Space Cytosol Plasma Membrane Caveola External Side Of Plasma Membrane Cell Surface Membrane Nuclear Body Receptor Complex Membrane Raft Activin Receptor Complex Transforming Growth Factor Beta Ligand-receptor Complex
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Zinc Ion Binding Protein Domain Specific Binding Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type II Protein Binding ATP Binding Glycosaminoglycan Binding Kinase Activity Activin Receptor Activity, Type I Transferase Activity Kinase Activator Activity Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Signaling Receptor Activity SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding Molecular Adaptor Activity
	Biological Process	Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway Endosomal Transport	Blood Vessel Development Branching Involved In Blood Vessel Morphogenesis Vasculogenesis In Utero Embryonic Development Epithelial To Mesenchymal Transition Heart Looping Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Positive Regulation Of Tolerance Induction To Self Antigen Positive Regulation Of B Cell Tolerance Induction Positive Regulation Of T Cell Tolerance Induction Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Outflow Tract Morphogenesis Aortic Valve Morphogenesis Atrioventricular Valve Morphogenesis Tricuspid Valve Morphogenesis Cardiac Left Ventricle Morphogenesis Endocardial Cushion Fusion Growth Plate Cartilage Development Growth Plate Cartilage Chondrocyte Growth Apoptotic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Smoothened Signaling Pathway Gastrulation Nervous System Development Brain Development Heart Development Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Cell Differentiation Lung Development Activin Receptor Signaling Pathway Response To Lipid Embryonic Hemopoiesis Aorta Morphogenesis Regulation Of Cell Population Proliferation Myeloid Dendritic Cell Differentiation Positive Regulation Of Angiogenesis Animal Organ Development Blood Vessel Morphogenesis Embryonic Cranial Skeleton Morphogenesis Artery Morphogenesis Positive Regulation Of Developmental Process Positive Regulation Of NK T Cell Differentiation Cartilage Development Regulation Of Multicellular Organismal Process Roof Of Mouth Development Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Lung Morphogenesis Bronchus Development Bronchus Morphogenesis Trachea Morphogenesis Trachea Formation Mammary Gland Morphogenesis Lung Lobe Morphogenesis Langerhans Cell Differentiation Secondary Palate Development Response To Cholesterol Cellular Response To Growth Factor Stimulus Regulation Of Stem Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cell Proliferation Involved In Endocardial Cushion Morphogenesis Superior Endocardial Cushion Morphogenesis Inferior Endocardial Cushion Morphogenesis Lens Fiber Cell Apoptotic Process MiRNA Transport Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Regulation Of Stem Cell Differentiation
Pathways			Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer UCH proteinases TGFBR3 regulates TGF-beta signaling
Drugs			Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Fostamatinib
Diseases			Loeys-Dietz syndrome (LDS) Colorectal cancer Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		Hip circumference adjusted for BMI ( 34021172)	Breast cancer ( 23535729 29059683) Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168) Cognitive decline rate in late mild cognitive impairment ( 26252872) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Migraine ( 22683712 27322543) Migraine - clinic-based ( 23793025) Night sleep phenotypes ( 27126917) Postprandial triglyceride response ( 32603185) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Systolic blood pressure ( 30224653) Tonometry ( 17903302)
Interacting Genes		38 interacting genes: ANKLE2 BAG6 BMP4 CHD6 CLTC CTNNB1 DAZAP2 EIF4G1 ERBIN ETS2 FHL2 JUP LRP12 NIT1 NUP155 PML PPP1CA PPP1CB PPP1CC PPP2R1A RBBP6 RHOT2 RNF11 RNPEP SCYL2 SMAD2 SMAD3 SPART ST7 SUMF2 SUPT5H SVEP1 TENT5A TGFBR1 TGFBR2 UBC UBXN11 ZMYND8	51 interacting genes: ACVR1 ACVRL1 AP2B1 APP ARHGEF6 ARHGEF7 CCNB1 CCNB2 CD44 CDK1 CLU CRIPTO CTNNB1 DAB2 DAXX DYNLT4 EIF3I ENG FANCC GOPC KCNK18 MAP2K1 NRP1 OSR1 PAK1 PDGFRA PIK3R1 PIK3R2 PML PPP2CB PSMD14 RCVRN SMAD3 SMAD4 SMAD7 SNX6 STRAP TERT TGFB1 TGFB1I1 TGFB2 TGFB3 TGFBR1 TGFBR3 TGFBRAP1 TRAP1 TRMO TSSK1B USP8 ZFYVE9 ZNF510
Entrez ID		9372	7048
HPRD ID		04782	01823
Ensembl ID		ENSG00000157077	ENSG00000163513
Uniprot IDs		O95405	A0AAQ5BI06 A3QNQ0 D2JYI1 P37173
PDB IDs		1DEV 1MK2 4BKW 5MJY	1KTZ 1M9Z 1PLO 2PJY 3KFD 4P7U 4XJJ 5E8V 5E8Y 5E91 5E92 5QIN 5TX4 5TY4 7DV6 8G4K 8YGZ 9B9F 9E9G 9FDY 9FK5 9FKP
Enriched GO Terms of Interacting Partners?		Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Ubiquitin Protein Ligase Binding Embryonic Skeletal System Morphogenesis I-SMAD Binding SMAD Binding Lung Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Skeletal System Morphogenesis Entrainment Of Circadian Clock By Photoperiod Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Signal Transduction Trachea Formation Trophoblast Cell Migration PTW/PP1 Phosphatase Complex Embryonic Organ Morphogenesis Photoperiodism Entrainment Of Circadian Clock Activin Receptor Signaling Pathway Embryonic Foregut Morphogenesis Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Cell Fate Commitment Tissue Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Tissue Development Gastrulation Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Branching Involved In Lung Morphogenesis Tube Morphogenesis Positive Regulation Of Developmental Process Regulation Of Chondrocyte Differentiation Positive Regulation Of Transcription Elongation By RNA Polymerase II Mesenchyme Development Regulation Of Developmental Process Formation Of Primary Germ Layer Branching Morphogenesis Of An Epithelial Tube Osteoblast Differentiation Bronchus Development Animal Organ Formation Positive Regulation Of DNA-templated Transcription, Elongation Catenin-TCF7L2 Complex Paraxial Mesoderm Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Regulation Of Translation In Response To Stress Circadian Regulation Of Gene Expression In Utero Embryonic Development Regulation Of SMAD Protein Signal Transduction Developmental Growth	Transforming Growth Factor Beta Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Response To Growth Factor Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Binding Regulation Of Apoptotic Process Tissue Morphogenesis Heart Development Regulation Of Programmed Cell Death Positive Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Regulation Of Cell Population Proliferation Type II Transforming Growth Factor Beta Receptor Binding Regulation Of Signal Transduction Tube Morphogenesis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Cell Migration Positive Regulation Of Cell Communication Positive Regulation Of Signaling Anatomical Structure Morphogenesis I-SMAD Binding Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Cell Motility Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Locomotion Regulation Of Developmental Process Regulation Of Growth Regulation Of Cell Differentiation Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Cell Population Proliferation Regulation Of Cell Migration Multicellular Organism Development Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Differentiation Transforming Growth Factor Beta Binding Mesenchymal Cell Differentiation
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