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ATP6V0B and IRAK3
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
ATP6V0B
IRAK3
Description
ATPase H+ transporting V0 subunit b
interleukin 1 receptor associated kinase 3
Image
GO Annotations
Cellular Component
Golgi Membrane
Vacuolar Proton-transporting V-type ATPase, V0 Domain
Lysosomal Membrane
Endosome
Plasma Membrane
Endosome Membrane
Membrane
Clathrin-coated Vesicle Membrane
Phagocytic Vesicle Membrane
Cytoplasmic Vesicle
Proton-transporting V-type ATPase Complex
Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain
Proton-transporting V-type ATPase, V0 Domain
Nucleus
Cytoplasm
Plasma Membrane
Molecular Function
Protein Binding
Proton Transmembrane Transporter Activity
Proton-transporting ATPase Activity, Rotational Mechanism
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Biological Process
Monoatomic Ion Transport
Vacuolar Acidification
Lysosomal Lumen Acidification
Regulation Of Macroautophagy
Endosomal Lumen Acidification
Intracellular PH Reduction
Golgi Lumen Acidification
Proton Transmembrane Transport
Positive Regulation Of Cytokine Production
Negative Regulation Of Cytokine-mediated Signaling Pathway
Positive Regulation Of Immune System Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Signal Transduction
Toll Signaling Pathway
Response To Virus
Positive Regulation Of Macrophage Tolerance Induction
Negative Regulation Of Macrophage Cytokine Production
Cytokine-mediated Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Response To Peptidoglycan
Response To Lipopolysaccharide
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Toll-like Receptor Signaling Pathway
Intracellular Signal Transduction
Negative Regulation Of Protein Catabolic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Protein-containing Complex Disassembly
Regulation Of Protein-containing Complex Disassembly
Response To Exogenous DsRNA
Negative Regulation Of MAPK Cascade
Regulation Of Innate Immune Response
Negative Regulation Of Innate Immune Response
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Pathways
ROS and RNS production in phagocytes
Insulin receptor recycling
Transferrin endocytosis and recycling
Amino acids regulate mTORC1
Ion channel transport
Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Interleukin-1 signaling
Drugs
Tiludronic acid
Fostamatinib
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Response to esketamine in treatment resistant depression (
32724131
)
Smooth-surface caries (
24556642
)
White blood cell count (basophil) (
29403010
)
Interacting Genes
28 interacting genes:
ADGRG3
ADRB2
APOD
COL4A5
EMP1
FAM210B
FAS
GJA8
GPR42
GPR61
INSIG2
IRAK3
KLRC1
MFF
MIP
MS4A3
MTNR1B
NRM
SLC10A1
SLC2A5
SNTA1
SPACA1
STOM
TM4SF19
TMEM242
VMA21
YWHAE
YWHAG
17 interacting genes:
ADH1B
ATP6V0B
CD14
CDCA5
COPB1
ECM1
FOLR1
HOXB7
IRAK1
IRAK2
LDB1
MYD88
NONO
NSA2
NTRK3
TICAM2
TRAF6
Entrez ID
533
11213
HPRD ID
04759
05123
Ensembl ID
ENSG00000117410
ENSG00000090376
Uniprot IDs
E9PNL3
Q99437
Q9Y616
PDB IDs
6WLW
6WM2
6WM3
6WM4
7U4T
7UNF
5UKE
6RUU
6ZIW
Enriched GO Terms of Interacting Partners
?
Membrane
Specific Granule Membrane
Gap Junction-mediated Intercellular Transport
Protein Sequestering Activity
Intercellular Transport
Cell Surface Toll-like Receptor Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Cell Surface Pattern Recognition Receptor Signaling Pathway
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Activation Of Innate Immune Response
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Endosome Membrane
Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Innate Immune Response
Interleukin-1-mediated Signaling Pathway
Innate Immune Response-activating Signaling Pathway
Positive Regulation Of Type I Interferon Production
Toll Signaling Pathway
Interleukin-33-mediated Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Activation Of Immune Response
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Innate Immune Response
Regulation Of Type I Interferon Production
Positive Regulation Of Defense Response
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Canonical NF-kappaB Signal Transduction
Cellular Response To Lipopolysaccharide
Cellular Response To Oxygen-containing Compound
Immune Response-activating Signaling Pathway
Cellular Response To Molecule Of Bacterial Origin
Signaling Adaptor Activity
Response To Interleukin-1
Regulation Of Immune Response
Positive Regulation Of Immune Response
Immune Response-regulating Signaling Pathway
Endolysosomal Toll-like Receptor Signaling Pathway
Cellular Response To Lipid
Non-canonical NF-kappaB Signal Transduction
Regulation Of Toll-like Receptor 4 Signaling Pathway
Regulation Of Immune System Process
Regulation Of Defense Response
Response To Lipopolysaccharide
Response To Molecule Of Bacterial Origin
Defense Response
Innate Immune Response
Regulation Of Cytokine-mediated Signaling Pathway
Canonical NF-kappaB Signal Transduction
Positive Regulation Of Immune System Process
Response To Stress
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Defense Response To Symbiont
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Tagcloud (Difference)
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Tagcloud (Intersection)
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