ATP6V0B and BPI

Data Source: HiPPIP (Novel)

		ATP6V0B	BPI
Name		ATPase H+ transporting V0 subunit b	bactericidal permeability increasing protein
Structure
GO Annotations	Cellular Component	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Membrane Endosome Plasma Membrane Endosome Membrane Membrane Clathrin-coated Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Proton-transporting V-type ATPase, V0 Domain	Extracellular Region Extracellular Space Cytoplasmic Stress Granule Membrane Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome
	Molecular Function	Protein Binding Proton Transmembrane Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism	Lipopolysaccharide Binding Lipid Binding
	Biological Process	Monoatomic Ion Transport Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Macroautophagy Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Proton Transmembrane Transport	Immune System Process Antibacterial Humoral Response Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Defense Response To Bacterium Negative Regulation Of Macrophage Activation Innate Immune Response Defense Response To Gram-negative Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	Toll Like Receptor 4 (TLR4) Cascade Neutrophil degranulation Antimicrobial peptides
Drugs		Tiludronic acid	Di-Stearoyl-3-Sn-Phosphatidylcholine
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 )	Basophil count ( 32888494 ) Carboplatin disposition in epthelial ovarian cancer ( 29367611 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) White blood cell count ( 32888494 )
Interacting Genes		28 interacting genes: ADGRG3 ADRB2 APOD COL4A5 EMP1 FAM210B FAS GJA8 GPR42 GPR61 INSIG2 IRAK3 KLRC1 MFF MIP MS4A3 MTNR1B NRM SLC10A1 SLC2A5 SNTA1 SPACA1 STOM TM4SF19 TMEM242 VMA21 YWHAE YWHAG	1 interacting genes: PRSS2
Entrez ID		533	671
HPRD ID		04759	00174
Ensembl ID		ENSG00000117410	ENSG00000101425
Uniprot IDs		E9PNL3 Q99437	A0A2R8YDF1 P17213
PDB IDs		6WLW 6WM2 6WM3 6WM4 7U4T 7UNF	1BP1 1EWF
GO Terms Enriched among Interactors		Membrane Specific Granule Membrane Gap Junction-mediated Intercellular Transport Protein Sequestering Activity Intercellular Transport	Proton-transporting V-type ATPase, V0 Domain Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Lumen Acidification Endosomal Lumen Acidification Proton Transmembrane Transporter Activity Proton-transporting V-type ATPase Complex Proton-transporting ATPase Activity, Rotational Mechanism Clathrin-coated Vesicle Membrane Regulation Of Lysosomal Lumen PH Vacuolar Acidification Digestion Collagen Catabolic Process Extracellular Matrix Disassembly Intracellular PH Reduction Collagen Metabolic Process