ATP6V0B and GPR61

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ATP6V0B	GPR61
Name		ATPase H+ transporting V0 subunit b	G protein-coupled receptor 61
Structure
GO Annotations	Cellular Component	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Membrane Endosome Plasma Membrane Endosome Membrane Membrane Clathrin-coated Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Proton-transporting V-type ATPase, V0 Domain	Endosome Plasma Membrane Endosome Membrane Membrane Receptor Complex
	Molecular Function	Protein Binding Proton Transmembrane Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism	G Protein-coupled Receptor Activity Protein Binding Arrestin Family Protein Binding
	Biological Process	Monoatomic Ion Transport Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Macroautophagy Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Proton Transmembrane Transport	Signal Transduction G Protein-coupled Receptor Signaling Pathway Ligand-independent Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	None
Drugs		Tiludronic acid	None
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 )	Adult body size ( 32376654 ) Body mass index ( 28448500 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index in physically active individuals ( 28448500 ) Body size at age 10 ( 32376654 ) Childhood body mass index ( 26604143 ) Chronotype ( 30696823 ) Hepcidin/ferritin ratio ( 27846281 ) Morning person ( 30696823 ) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189 ) Stearic acid (18:0) levels ( 23362303 ) Waist circumference ( 25673412 )
Interacting Genes		28 interacting genes: ADGRG3 ADRB2 APOD COL4A5 EMP1 FAM210B FAS GJA8 GPR42 GPR61 INSIG2 IRAK3 KLRC1 MFF MIP MS4A3 MTNR1B NRM SLC10A1 SLC2A5 SNTA1 SPACA1 STOM TM4SF19 TMEM242 VMA21 YWHAE YWHAG	20 interacting genes: APP ARL6IP6 ARLN ATP6V0B CLDND1 CTXN3 EMP3 FCER1G GJA8 GJB6 KLRC1 PLP1 PMP22 SCN3B SLC12A7 SLC13A4 STRIT1 TMEM147 TMEM218 TRARG1
Entrez ID		533	83873
HPRD ID		04759	06077
Ensembl ID		ENSG00000117410	ENSG00000156097
Uniprot IDs		E9PNL3 Q99437	G4XH66 Q9BZJ8
PDB IDs		6WLW 6WM2 6WM3 6WM4 7U4T 7UNF	8KGK 8TB0 8TB7
GO Terms Enriched among Interactors		Membrane Specific Granule Membrane Gap Junction-mediated Intercellular Transport Protein Sequestering Activity Intercellular Transport	Membrane Plasma Membrane Gap Junction-mediated Intercellular Transport Cell-cell Signaling Signaling Bleb Assembly Intercellular Transport Cell Communication Transmembrane Transport Connexin Complex Gap Junction Channel Activity Chemical Synaptic Transmission Protein Localization To Membrane Gap Junction Trans-synaptic Signaling Synaptic Signaling