ATP6V0B and TTC39A

Data Source: HiPPIP (Novel)

		ATP6V0B	TTC39A
Name		ATPase H+ transporting V0 subunit b	tetratricopeptide repeat domain 39A
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Membrane Endosome Plasma Membrane Endosome Membrane Membrane Clathrin-coated Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Proton-transporting V-type ATPase, V0 Domain	Centrosome
	Molecular Function	Protein Binding Proton Transmembrane Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism	Protein Binding
	Biological Process	Monoatomic Ion Transport Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Macroautophagy Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Proton Transmembrane Transport	None
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	None
Drugs		Tiludronic acid	None
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 )	Hip circumference adjusted for BMI ( 34021172 ) Lymphocyte percentage of white cells ( 27863252 )
Novel Interactors		6 novel interactors: BPI CCL19 DAPK2 RPS26P15 TTC39A ZFYVE9	2 novel interactors: ATP6V0B NRDC
Interacting Genes		28 interacting genes: ADGRG3 ADRB2 APOD COL4A5 EMP1 FAM210B FAS GJA8 GPR42 GPR61 INSIG2 IRAK3 KLRC1 MFF MIP MS4A3 MTNR1B NRM SLC10A1 SLC2A5 SNTA1 SPACA1 STOM TM4SF19 TMEM242 VMA21 YWHAE YWHAG	1 interacting genes: TNIP1
Entrez ID		533	22996
HPRD ID		04759	10727
Ensembl ID		ENSG00000117410	ENSG00000085831
Uniprot IDs		E9PNL3 Q99437	A0A0A0MRQ0 A0A0A0MSW9 A0A140VJY6 A0A7P0T922 B7Z4W9 F6WE04 Q5SRH9
PDB IDs		6WLW 6WM2 6WM3 6WM4 7U4T 7UNF	Not available
GO Terms Enriched among Interactors		Membrane Specific Granule Membrane Gap Junction-mediated Intercellular Transport Protein Sequestering Activity Intercellular Transport	None