ATP6V0B and DAPK2

Data Source: HiPPIP (Novel)

		ATP6V0B	DAPK2
Name		ATPase H+ transporting V0 subunit b	death associated protein kinase 2
Structure
GO Annotations	Cellular Component	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Membrane Endosome Plasma Membrane Endosome Membrane Membrane Clathrin-coated Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Proton-transporting V-type ATPase, V0 Domain	Nucleus Cytoplasm Golgi Apparatus Cytoplasmic Vesicle Autophagosome Lumen
	Molecular Function	Protein Binding Proton Transmembrane Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Monoatomic Ion Transport Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Macroautophagy Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Proton Transmembrane Transport	Protein Phosphorylation Apoptotic Process Regulation Of Autophagy Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Anoikis Protein Autophosphorylation Positive Regulation Of Neutrophil Chemotaxis Neutrophil Migration Positive Regulation Of Eosinophil Chemotaxis Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	Caspase activation via Dependence Receptors in the absence of ligand
Drugs		Tiludronic acid	Fostamatinib
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 )	Arterial stiffness index ( 31235810 ) Cerebral amyloid deposition (PET imaging) ( 30361487 ) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921 ) HDL cholesterol levels ( 32203549 ) Platelet distribution width ( 27863252 ) Systolic blood pressure x dichotomous lifestyle risk score interaction (1df test) ( 32227373 ) Systolic blood pressure x dichotomous lifestyle risk score interaction (2df test) ( 32227373 ) Triglyceride levels ( 31647587 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 )
Interacting Genes		28 interacting genes: ADGRG3 ADRB2 APOD COL4A5 EMP1 FAM210B FAS GJA8 GPR42 GPR61 INSIG2 IRAK3 KLRC1 MFF MIP MS4A3 MTNR1B NRM SLC10A1 SLC2A5 SNTA1 SPACA1 STOM TM4SF19 TMEM242 VMA21 YWHAE YWHAG	6 interacting genes: APP CAMK2A CCDC91 FAM9B MLC1 TGFBR1
Entrez ID		533	23604
HPRD ID		04759	09905
Ensembl ID		ENSG00000117410	ENSG00000035664
Uniprot IDs		E9PNL3 Q99437	Q1RMF4 Q9UIK4
PDB IDs		6WLW 6WM2 6WM3 6WM4 7U4T 7UNF	1WMK 1WRZ 1Z9X 1ZUZ 1ZWS 2A27 2A2A 2CKE 6PAW 7A6R 7A6Y
GO Terms Enriched among Interactors		Membrane Specific Granule Membrane Gap Junction-mediated Intercellular Transport Protein Sequestering Activity Intercellular Transport	Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Signaling Pathway Response To Cholesterol Membrane Raft Peptidyl-serine Phosphorylation Endosome Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Regulation Of Developmental Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Peptidyl-threonine Autophosphorylation Protein Phosphorylation Positive Regulation Of Hepatocyte Apoptotic Process Identical Protein Binding Regulation Of Cell Migration Regulation Of Apoptotic Signaling Pathway Phosphorylation Protein Serine/threonine Kinase Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Locomotion Endosome To Plasma Membrane Transport Vesicle Protein Tetramerization Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Regulation Of Cell Motility Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Protein Autophosphorylation Protein Kinase Activity Regulation Of Endocannabinoid Signaling Pathway Regulation Of Organ Growth Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Negative Regulation Of Canonical Wnt Signaling Pathway