ATP6V0B and ADGRG3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ATP6V0B	ADGRG3
Description		ATPase H+ transporting V0 subunit b	adhesion G protein-coupled receptor G3
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GO Annotations	Cellular Component	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Membrane Endosome Plasma Membrane Endosome Membrane Membrane Clathrin-coated Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Proton-transporting V-type ATPase, V0 Domain	Plasma Membrane Membrane Specific Granule Membrane
	Molecular Function	Protein Binding Proton Transmembrane Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Monoatomic Ion Transport Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Macroautophagy Endosomal Lumen Acidification Intracellular PH Reduction Golgi Lumen Acidification Proton Transmembrane Transport	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway B Cell Differentiation Regulation Of Cell Migration Negative Regulation Of CREB Transcription Factor Activity Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	Neutrophil degranulation
Drugs		Tiludronic acid
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		28 interacting genes: ADGRG3 ADRB2 APOD COL4A5 EMP1 FAM210B FAS GJA8 GPR42 GPR61 INSIG2 IRAK3 KLRC1 MFF MIP MS4A3 MTNR1B NRM SLC10A1 SLC2A5 SNTA1 SPACA1 STOM TM4SF19 TMEM242 VMA21 YWHAE YWHAG	12 interacting genes: ARLN ATP6V0B C3orf52 CTXN3 GIMAP5 LHFPL5 PLP1 RPRM SEC22A TEX264 UPK2 VSTM1
Entrez ID		533	222487
HPRD ID		04759	17073
Ensembl ID		ENSG00000117410	ENSG00000182885
Uniprot IDs		E9PNL3 Q99437	B4DVW2 F8W8F7 H3BRU4 Q86Y34
PDB IDs		6WLW 6WM2 6WM3 6WM4 7U4T 7UNF	7D76 7D77 7QU8
Enriched GO Terms of Interacting Partners?		Membrane Specific Granule Membrane Gap Junction-mediated Intercellular Transport Protein Sequestering Activity Intercellular Transport	Membrane
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