ZFYVE9 and SUMF2

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		ZFYVE9	SUMF2
Gene Name		zinc finger, FYVE domain containing 9	sulfatase modifying factor 2
Image
Gene Ontology Annotations	Cellular Component	Early Endosome Early Endosome Membrane	Endoplasmic Reticulum Lumen
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Serine-type Peptidase Activity Metal Ion Binding	Metal Ion Binding
	Biological Process	Proteolysis Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly SMAD Protein Import Into Nucleus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism Post-translational protein modification The activation of arylsulfatases Gamma carboxylation, hypusine formation and arylsulfatase activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: ANKLE2 BAG6 BMP4 CHD6 CLTC CTNNB1 DAZAP2 EIF4G1 ERBB2IP ETS2 FAM46A FHL2 JUP LRP12 NIT1 NUP155 PML PPP1CA PPP1CB PPP1CC PPP2R1A RBBP6 RHOT2 RNF11 RNPEP SCYL2 SMAD2 SMAD3 SPG20 ST7 SUMF2 SUPT5H SVEP1 TGFBR1 TGFBR2 UBC UBXN11 ZMYND8	4 interactors: CACNA1A FBXW7 ZDHHC17 ZFYVE9
Entrez ID		9372	25870
HPRD ID		04782	06400
Ensembl ID		ENSG00000157077	ENSG00000129103
Uniprot IDs		O95405	Q8NBJ7
PDB IDs		1DEV 1MK2 4BKW	1Y4J
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Common-partner SMAD Protein Phosphorylation Cell Cycle Trachea Formation Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Embryonic Skeletal System Morphogenesis Entrainment Of Circadian Clock By Photoperiod Embryonic Cranial Skeleton Morphogenesis Cellular Response To Organic Substance Response To Organic Substance Photoperiodism Entrainment Of Circadian Clock Embryonic Skeletal System Development Lens Development In Camera-type Eye Cell Cycle Process Regulation Of Growth Signal Transduction Trachea Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Embryonic Foregut Morphogenesis Regulation Of Gene Expression Foregut Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Lung Development Negative Regulation Of Growth Negative Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Morphogenesis Respiratory Tube Development Glycogen Metabolic Process Regulation Of Chondrocyte Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Signaling Skeletal System Morphogenesis Tube Morphogenesis Negative Regulation Of Biosynthetic Process Positive Regulation Of Cell Death	Cerebellar Molecular Layer Development Negative Regulation Of SREBP Signaling Pathway Regulation Of Signaling Negative Regulation Of Triglyceride Biosynthetic Process Vestibular Nucleus Development Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Regulation Of Neuron Apoptotic Process Negative Regulation Of Hepatocyte Proliferation Gamma-aminobutyric Acid Secretion Negative Regulation Of DNA Endoreduplication Regulation Of Acetylcholine Secretion, Neurotransmission Regulation Of Neuron Death Rhythmic Synaptic Transmission Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Oxidative Stress-induced Cell Death Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis SMAD Protein Import Into Nucleus Gamma-aminobutyric Acid Transport Chloride Ion Homeostasis Regulation Of DNA Endoreduplication Regulation Of Hepatocyte Proliferation Negative Regulation Of Hormone Biosynthetic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Pons Development SMAD Protein Complex Assembly Protein Localization Signal Transduction Cerebellar Purkinje Cell Differentiation Cerebellar Purkinje Cell Layer Morphogenesis Regulation Of Triglyceride Biosynthetic Process Signaling Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Lipoprotein Transport Magnesium Ion Transport Cell Communication Reflex Behavioral Response To Pain Positive Regulation Of ERBB Signaling Pathway Neuromuscular Synaptic Transmission SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Hormone Biosynthetic Process Cerebellar Cortex Formation Neurotransmitter Metabolic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Sister Chromatid Cohesion Protein Palmitoylation
Tagcloud ?		calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes
Tagcloud (Difference) ?		calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes
Tagcloud (Intersection) ?