ZFYVE9 and NIT1

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZFYVE9	NIT1
Description		zinc finger FYVE-type containing 9	nitrilase 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Membrane Early Endosome Membrane Protein-containing Complex	Nucleus Cytoplasm Mitochondrion
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Zinc Ion Binding Protein Domain Specific Binding Metal Ion Binding	Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Deaminated Glutathione Amidase Activity
	Biological Process	Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway Endosomal Transport	Amide Catabolic Process
Pathways
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		38 interacting genes: ANKLE2 BAG6 BMP4 CHD6 CLTC CTNNB1 DAZAP2 EIF4G1 ERBIN ETS2 FHL2 JUP LRP12 NIT1 NUP155 PML PPP1CA PPP1CB PPP1CC PPP2R1A RBBP6 RHOT2 RNF11 RNPEP SCYL2 SMAD2 SMAD3 SPART ST7 SUMF2 SUPT5H SVEP1 TENT5A TGFBR1 TGFBR2 UBC UBXN11 ZMYND8	3 interacting genes: ATXN1L XRCC6 ZFYVE9
Entrez ID		9372	4817
HPRD ID		04782	07056
Ensembl ID		ENSG00000157077	ENSG00000158793
Uniprot IDs		O95405	B7Z410 Q86X76
PDB IDs		1DEV 1MK2 4BKW 5MJY
Enriched GO Terms of Interacting Partners?		Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Ubiquitin Protein Ligase Binding Embryonic Skeletal System Morphogenesis I-SMAD Binding SMAD Binding Lung Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Skeletal System Morphogenesis Entrainment Of Circadian Clock By Photoperiod Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Signal Transduction Trachea Formation Trophoblast Cell Migration PTW/PP1 Phosphatase Complex Embryonic Organ Morphogenesis Photoperiodism Entrainment Of Circadian Clock Activin Receptor Signaling Pathway Embryonic Foregut Morphogenesis Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Cell Fate Commitment Tissue Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Tissue Development Gastrulation Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Branching Involved In Lung Morphogenesis Tube Morphogenesis Positive Regulation Of Developmental Process Regulation Of Chondrocyte Differentiation Positive Regulation Of Transcription Elongation By RNA Polymerase II Mesenchyme Development Regulation Of Developmental Process Formation Of Primary Germ Layer Branching Morphogenesis Of An Epithelial Tube Osteoblast Differentiation Bronchus Development Animal Organ Formation Positive Regulation Of DNA-templated Transcription, Elongation Catenin-TCF7L2 Complex Paraxial Mesoderm Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Regulation Of Translation In Response To Stress Circadian Regulation Of Gene Expression In Utero Embryonic Development Regulation Of SMAD Protein Signal Transduction Developmental Growth	Positive Regulation Of Type I Hypersensitivity Mast Cell Apoptotic Process Serotonin Secretion Negative Regulation Of Mast Cell Apoptotic Process IgE Receptor Activity Positive Regulation Of Type IIa Hypersensitivity Serotonin Secretion By Platelet Positive Regulation Of Mast Cell Cytokine Production IgE Binding Regulation Of Mast Cell Apoptotic Process Fc-gamma Receptor III Complex Fc-epsilon Receptor I Complex Positive Regulation Of Type III Hypersensitivity DNA End Binding Cellular Hyperosmotic Salinity Response DNA-dependent Protein Kinase Complex Ku70:Ku80 Complex POZ Domain Binding Positive Regulation Of Hypersensitivity Interleukin-3-mediated Signaling Pathway Hyperosmotic Salinity Response DNA-dependent Protein Kinase-DNA Ligase 4 Complex 5'-deoxyribose-5-phosphate Lyase Activity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Mast Cell Activation Nonhomologous End Joining Complex Nuclear Telomere Cap Complex Double-stranded Telomeric DNA Binding Positive Regulation Of Hematopoietic Stem Cell Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cellular Response To X-ray Cellular Response To Salt Stress Double-strand Break Repair Via Classical Nonhomologous End Joining Neutrophil Activation Involved In Immune Response Serotonin Transport IgG Binding Positive Regulation Of Inflammatory Response To Antigenic Stimulus 1-phosphatidylinositol Binding Plasma Membrane Protein Complex Positive Regulation Of Mast Cell Degranulation Activation Of Immune Response Myeloid Cell Apoptotic Process Regulation Of Acute Inflammatory Response To Antigenic Stimulus Endocytosis Regulation Of Hematopoietic Stem Cell Proliferation Positive Regulation Of Defense Response Cellular Hyperosmotic Response Positive Regulation Of Protein Localization To Cell Surface Response To Salt Stress Negative Regulation Of Myeloid Cell Apoptotic Process
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