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COPS2 and COPS6
Number of citations of the paper that reports this interaction (PubMedID
11285227
)
43
Data Source:
HPRD
(in vitro)
COPS2
COPS6
Description
COP9 signalosome subunit 2
COP9 signalosome subunit 6
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
COP9 Signalosome
Protein-containing Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
COP9 Signalosome
Perinuclear Region Of Cytoplasm
Molecular Function
Transcription Corepressor Activity
Protein Binding
Protein Binding
Peptidase Activity
Metal-dependent Deubiquitinase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Deneddylation
Inner Cell Mass Cell Proliferation
Trophectodermal Cell Proliferation
Transcription By RNA Polymerase II
Protein Phosphorylation
Signal Transduction
Neuron Differentiation
Skeletal Muscle Cell Differentiation
Protein Neddylation
Negative Regulation Of DNA-templated Transcription
Regulation Of Protein Neddylation
Protein Deneddylation
Protein Neddylation
Regulation Of Protein Neddylation
Pathways
DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation
RHOBTB1 GTPase cycle
DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation
Drugs
Diseases
GWAS
Lung adenocarcinoma (
28604730
)
Lung cancer (
28604730
)
Lung function (FEV1/FVC) (
30804560
)
Peak expiratory flow (
30804560
)
Brain morphology (MOSTest) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
39 interacting genes:
COPS3
COPS4
COPS5
COPS6
COPS7A
COPS8
CSNK2A1
CUL4A
CUL5
EP300
GFER
GPS1
H3C1
H4C1
ING1
ING2
IP6K1
IRF8
MAP3K10
MAPK8
NCOR1
NIF3L1
NR0B1
NR2F1
OGT
PRKD1
PSMD11
RARA
RND1
RXRA
SENP8
SIN3A
SIN3B
THRA
THRB
TP53
UBC
VDR
ZNF446
95 interacting genes:
ANXA1
ANXA7
ASH2L
BFSP2
BTBD2
C1orf174
C4orf17
CASP3
CASP6
CASP7
CASP8
CCBE1
CCDC106
CDH10
CDKN1A
CDKN2C
CHRNB1
COPS2
COPS3
COPS4
COPS5
COPS8
COX17
COX5A
CRELD1
CRIPTO
CUL1
CUL5
DIS3L2
DLEU1
DSP
EDN1
EIF3E
EMD
EP300
ERH
FAU
GPS1
HMOX2
LAMA4
LPL
MAP3K1
MAP7D1
MAPK1
MAPK6
MAPKAPK3
MIF
MNAT1
MYCBP
NEDD8
NR3C1
ORAI2
PAEP
PAFAH1B3
PBX2
PDZK1IP1
PFKL
PHYHIP
PMF1
PRKRA
PSAP
PSMD11
PTEN
QTRT1
RAB27A
RBX1
RFC5
ROGDI
RPA2
RPL15
S100A10
SAT1
SERPINA5
SERPINB9
SHANK3
SHC3
SLC2A1
SMN1
SNRPG
STAMBPL1
STK40
STX5
SULT1E1
TK1
TP53
TP63
TRDMT1
TRIB3
UBC
USHBP1
VIM
WIPI2
ZEB2
ZFHX3
ZNF24
Entrez ID
9318
10980
HPRD ID
05146
16735
Ensembl ID
ENSG00000166200
ENSG00000168090
Uniprot IDs
P61201
Q59EL2
Q7L5N1
PDB IDs
4D10
4D18
4WSN
6A73
6R6H
6R7F
6R7H
6R7I
6R7N
8H38
8H3A
8H3F
4D10
4D18
4QFT
4R14
4WSN
6R6H
6R7F
6R7H
6R7I
8H38
8H3A
8H3F
Enriched GO Terms of Interacting Partners
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Protein Deneddylation
Regulation Of Protein Neddylation
Protein Neddylation
COP9 Signalosome
Nucleoplasm
Sin3-type Complex
Negative Regulation Of Transcription By RNA Polymerase II
Nucleus
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Modification By Small Protein Removal
Negative Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Retinoic Acid Receptor Signaling Pathway
Negative Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Nuclear Receptor Activity
MRNA Transcription
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Metabolic Process
Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway
Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Protein Modification Process
Chromatin
Regulation Of Post-translational Protein Modification
MRNA Transcription By RNA Polymerase II
Regulation Of Nucleobase-containing Compound Metabolic Process
Rhythmic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Intracellular Signal Transduction
Histone Deacetylase Regulator Activity
Positive Regulation Of RNA Metabolic Process
Post-translational Protein Modification
Regulation Of Thyroid Hormone Receptor Signaling Pathway
DeNEDDylase Activity
Negative Regulation Of Stem Cell Population Maintenance
Retinoic Acid-responsive Element Binding
Regulation Of Protein Metabolic Process
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Macromolecule Metabolic Process
Intracellular Receptor Signaling Pathway
Protein Metabolic Process
Regulation Of Protein Modification Process
Cytosol
Protein Neddylation
Protein Deneddylation
Regulation Of Protein Neddylation
Nucleoplasm
Heart Development
COP9 Signalosome
Developmental Process
Cytosol
Cellular Response To Staurosporine
Intrinsic Apoptotic Signaling Pathway
Regulation Of Protein Metabolic Process
Ubiquitin Protein Ligase Binding
Signal Transduction By P53 Class Mediator
Cellular Response To Nutrient Levels
Protein Binding
Positive Regulation Of Neuron Apoptotic Process
Protease Binding
Pyroptotic Inflammatory Response
Protein Modification By Small Protein Removal
Nucleus
Animal Organ Development
Regulation Of Cell Cycle G1/S Phase Transition
Cytoplasm
Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Cellular Developmental Process
Cell Differentiation
Macromolecule Metabolic Process
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Keratinocyte Differentiation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Macromolecule Metabolic Process
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Scaffold Protein Binding
MAPK Cascade
Cellular Response To Alkaloid
Regulation Of Protein Modification Process
Positive Regulation Of Programmed Cell Death
Post-translational Protein Modification
Protein Modification Process
Regulation Of Post-translational Protein Modification
Protein Tag Activity
Cullin-RING Ubiquitin Ligase Complex
Protein-containing Complex
Cellular Response To Starvation
Response To Nutrient Levels
Mitotic G1 DNA Damage Checkpoint Signaling
Rhythmic Synaptic Transmission
G1/S Transition Of Mitotic Cell Cycle
Mitotic G1/S Transition Checkpoint Signaling
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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