COPS2 and CUL4A

Number of citations of the paper that reports this interaction (PubMedID 37390815)
0

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		COPS2	CUL4A
Description		COP9 signalosome subunit 2	cullin 4A
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding	Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Ligase Complex Scaffold Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Deneddylation Inner Cell Mass Cell Proliferation Trophectodermal Cell Proliferation Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Neuron Differentiation Skeletal Muscle Cell Differentiation Protein Neddylation Negative Regulation Of DNA-templated Transcription Regulation Of Protein Neddylation	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development DNA Repair Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Spermatogenesis Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Hemopoiesis Negative Regulation Of Granulocyte Differentiation Developmental Process Cellular Response To UV Somatic Stem Cell Population Maintenance MiRNA-mediated Gene Silencing By MRNA Destabilization T Cell Activation Ribosome Biogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Rhythmic Process Regulation Of Protein Metabolic Process Type I Interferon-mediated Signaling Pathway Intrinsic Apoptotic Signaling Pathway Base-excision Repair, AP Site Formation Via Deaminated Base Removal Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Damage Checkpoint Regulation Of Nucleotide-excision Repair
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation RHOBTB1 GTPase cycle	Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs
Diseases
GWAS		Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)	Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 30061737) Bipolar disorder ( 31043756 34002096) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Intracranial aneurysm ( 30823506) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 27863252 32888494) Red cell distribution width ( 32888494)
Interacting Genes		39 interacting genes: COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 CSNK2A1 CUL4A CUL5 EP300 GFER GPS1 H3C1 H4C1 ING1 ING2 IP6K1 IRF8 MAP3K10 MAPK8 NCOR1 NIF3L1 NR0B1 NR2F1 OGT PRKD1 PSMD11 RARA RND1 RXRA SENP8 SIN3A SIN3B THRA THRB TP53 UBC VDR ZNF446	25 interacting genes: CAND1 CDKN1B CENPA CHEK1 COMMD1 COPS2 DCUN1D4 DDB1 DDB2 H1-2 H3C1 HOXA9 LNCAROD PAFAH1B1 RBX1 SALL2 SENP8 SKP2 ST7 TP53 TUBG1 UBC UBE2D1 UBE2E3 UBE2M
Entrez ID		9318	8451
HPRD ID		05146	07218
Ensembl ID		ENSG00000166200	ENSG00000139842
Uniprot IDs		P61201 Q59EL2	A0A087WWN2 A0A0A0MR50 Q13619
PDB IDs		4D10 4D18 4WSN 6A73 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F	2HYE 4A0K 7OKQ 7OPC 7OPD 8B3G 8B3I
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Regulation Of Protein Neddylation Protein Neddylation COP9 Signalosome Nucleoplasm Sin3-type Complex Negative Regulation Of Transcription By RNA Polymerase II Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Removal Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Nuclear Receptor Activity MRNA Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Modification Process Chromatin Regulation Of Post-translational Protein Modification MRNA Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Rhythmic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Histone Deacetylase Regulator Activity Positive Regulation Of RNA Metabolic Process Post-translational Protein Modification Regulation Of Thyroid Hormone Receptor Signaling Pathway DeNEDDylase Activity Negative Regulation Of Stem Cell Population Maintenance Retinoic Acid-responsive Element Binding Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Intracellular Receptor Signaling Pathway Protein Metabolic Process Regulation Of Protein Modification Process Cytosol	Post-translational Protein Modification Protein Modification By Small Protein Conjugation Cul4A-RING E3 Ubiquitin Ligase Complex Nucleotide-excision Repair Protein Neddylation Cul4B-RING E3 Ubiquitin Ligase Complex Protein Modification Process Nucleus Positive Regulation Of Post-translational Protein Modification Regulation Of Post-translational Protein Modification Protein Ubiquitination Nucleoplasm Cullin Family Protein Binding Cellular Response To UV Cul4-RING E3 Ubiquitin Ligase Complex Base-excision Repair, AP Site Formation Via Deaminated Base Removal Cellular Response To Light Stimulus Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly NEDD8 Transferase Activity Regulation Of Protein Modification Process Ubiquitin-protein Transferase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Epigenetic Regulation Of Gene Expression Protein Polyubiquitination Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Regulation Of Mitotic Cell Cycle DNA Metabolic Process Macromolecule Metabolic Process Response To UV Cellular Response To Antibiotic Cell Cycle Phase Transition DNA Repair Protein-containing Complex Protein Metabolic Process UV-damage Excision Repair Cellular Response To Radiation Protein Deneddylation DNA Damage Response Negative Regulation Of Mitophagy Chromosome Organization Positive Regulation Of Protein Metabolic Process Interferon-mediated Signaling Pathway Protein-containing Complex Binding Regulation Of Protein Ubiquitination Nuclear Membrane Disassembly Inner Cell Mass Cell Proliferation Replicative Senescence
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