COPS2 and GFER

Number of citations of the paper that reports this interaction (PMID 15304329)
7

Data Source:
HPRD (in vivo)

		COPS2	GFER
Gene Name		COP9 signalosome subunit 2	growth factor, augmenter of liver regeneration
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm COP9 Signalosome	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Intermembrane Space
	Molecular Function	Transcription Corepressor Activity Signal Transducer Activity Protein Binding	Protein Binding Growth Factor Activity Protein Disulfide Oxidoreductase Activity Thiol Oxidase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Signal Transduction Cell Proliferation Cullin Deneddylation Neuron Differentiation Skeletal Muscle Cell Differentiation	Protein Targeting To Mitochondrion Cellular Protein Metabolic Process Oxidation-reduction Process
Pathways			Mitochondrial protein import
Drugs
Diseases
GWAS
Protein-Protein Interactions		39 interactors: COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 CSNK2A1 CSNK2B CUL1 CUL4A CUL5 DDB1 EP300 GFER GPS1 HIST1H3A HIST1H4A ING1 ING2 IP6K1 IRF8 JUN MAP3K10 MAPK8 NCOR1 NIF3L1 NR0B1 NR2F1 PRKD1 PSMD4 RARA RXRA SENP8 SIN3A SIN3B THRA THRB TP53 VDR	7 interactors: ASCC2 BNIPL COPS2 COPS5 PLEKHF2 SMAD2 TXN
Entrez ID		9318	2671
HPRD ID		05146	02954
Ensembl ID		ENSG00000166200	ENSG00000127554
Uniprot IDs		P61201 Q59EL2	P55789
PDB IDs			3MBG 3O55 3TK0 3U2L 3U2M 3U5S
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Cullin Deneddylation Negative Regulation Of Transcription, DNA-templated Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Protein Modification By Small Protein Removal Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Hormone-mediated Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Protein Metabolic Process Signal Transduction DNA-templated Transcription, Initiation Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Negative Regulation Of Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Signaling Cellular Response To Steroid Hormone Stimulus Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Regulation Of Protein Deacetylation Cellular Response To Lipid Metabolic Process Cell Communication Intracellular Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Cell Death Gene Expression	Cullin Deneddylation Protein Deneddylation Transcription, DNA-templated RNA Biosynthetic Process Protein Modification By Small Protein Removal Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry RNA Metabolic Process Regulation Of Growth Rate Zygotic Specification Of Dorsal/ventral Axis Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Exosomal Secretion Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Mesoderm Development Primary MiRNA Processing Negative Regulation Of Protein Export From Nucleus Regulation Of Nodal Signaling Pathway Common-partner SMAD Protein Phosphorylation Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Binding Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death SMAD Protein Complex Assembly Nucleobase-containing Compound Metabolic Process Regulation Of Hydrogen Peroxide-induced Cell Death Paraxial Mesoderm Morphogenesis Nodal Signaling Pathway Nucleobase-containing Small Molecule Interconversion Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Production Of MiRNAs Involved In Gene Silencing By MiRNA Embryonic Foregut Morphogenesis Foregut Morphogenesis
Tagcloud ?			acting alr apoptotic augmenter behaviour caspase clusterin complementary encodes erv1 glioma hepatectomized integrity lethal modulates named neuroblastoma normoxic oxidase peroxide preserve ralr regenerating regeneration ros shed sulfhydryl supports t98g
Tagcloud (Difference) ?			acting alr apoptotic augmenter behaviour caspase clusterin complementary encodes erv1 glioma hepatectomized integrity lethal modulates named neuroblastoma normoxic oxidase peroxide preserve ralr regenerating regeneration ros shed sulfhydryl supports t98g
Tagcloud (Intersection) ?