COPS2 and PSMD11

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		COPS2	PSMD11
Description		COP9 signalosome subunit 2	proteasome 26S subunit, non-ATPase 11
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Protein-containing Complex	Proteasome Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle Proteasome Regulatory Particle, Lid Subcomplex Membrane Proteasome Accessory Complex Protein-containing Complex Secretory Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Transcription Corepressor Activity Protein Binding	Structural Molecule Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Deneddylation Inner Cell Mass Cell Proliferation Trophectodermal Cell Proliferation Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Neuron Differentiation Skeletal Muscle Cell Differentiation Protein Neddylation Negative Regulation Of DNA-templated Transcription Regulation Of Protein Neddylation	Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasome Assembly Stem Cell Differentiation
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation RHOBTB1 GTPase cycle	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Neutrophil degranulation Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)	Schizophrenia ( 33169155)
Interacting Genes		39 interacting genes: COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 CSNK2A1 CUL4A CUL5 EP300 GFER GPS1 H3C1 H4C1 ING1 ING2 IP6K1 IRF8 MAP3K10 MAPK8 NCOR1 NIF3L1 NR0B1 NR2F1 OGT PRKD1 PSMD11 RARA RND1 RXRA SENP8 SIN3A SIN3B THRA THRB TP53 UBC VDR ZNF446	38 interacting genes: APP BRD7 CCDC90B CCSER2 CDC42 CEBPA COPS2 COPS6 CRMP1 EEF1A1 EEF1G GAPDH GDF9 HAP1 IGSF21 LRIF1 MED31 NFKB2 PRKAA1 PRKAB2 PRKACA PRMT6 PTN PTPRK RBM48 SETDB1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 TLE1 TP53 TUBB2A UNC119 USP4 ZBTB16 ZHX1
Entrez ID		9318	5717
HPRD ID		05146	05119
Ensembl ID		ENSG00000166200	ENSG00000108671
Uniprot IDs		P61201 Q59EL2	O00231
PDB IDs		4D10 4D18 4WSN 6A73 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F	5GJQ 5GJR 5L4K 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHS 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Regulation Of Protein Neddylation Protein Neddylation COP9 Signalosome Nucleoplasm Sin3-type Complex Negative Regulation Of Transcription By RNA Polymerase II Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Removal Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Nuclear Receptor Activity MRNA Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Modification Process Chromatin Regulation Of Post-translational Protein Modification MRNA Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Rhythmic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Histone Deacetylase Regulator Activity Positive Regulation Of RNA Metabolic Process Post-translational Protein Modification Regulation Of Thyroid Hormone Receptor Signaling Pathway DeNEDDylase Activity Negative Regulation Of Stem Cell Population Maintenance Retinoic Acid-responsive Element Binding Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Intracellular Receptor Signaling Pathway Protein Metabolic Process Regulation Of Protein Modification Process Cytosol	SMAD Protein Complex Heteromeric SMAD Protein Complex Transforming Growth Factor Beta Receptor Signaling Pathway I-SMAD Binding SMAD Protein Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Embryonic Pattern Specification Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Metabolic Process Cardiac Conduction System Development Cell Surface Receptor Signaling Pathway Transcription Regulator Complex Protein-containing Complex Intracellular Signaling Cassette Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process DEAD/H-box RNA Helicase Binding Regulation Of MiRNA Transcription Chromatin Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Regulation Of MiRNA Metabolic Process Nucleotide-activated Protein Kinase Complex Positive Regulation Of Cell Differentiation Ureteric Bud Development Co-SMAD Binding Negative Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Primary MiRNA Processing Signal Transduction Mesonephric Tubule Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Mesonephric Epithelium Development Gastrulation Homomeric SMAD Protein Complex Nucleus Response To Growth Factor Protein Kinase Binding Positive Regulation Of MiRNA Transcription Positive Regulation Of Gene Expression Response To Glucose
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