COPS2 and SENP8

Number of citations of the paper that reports this interaction (PMID 23408908)
4

Data Source:
BioGRID (affinity chromatography technology, far western blotting)

		COPS2	SENP8
Gene Name		COP9 signalosome subunit 2	SUMO/sentrin specific peptidase family member 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm COP9 Signalosome	Nucleus Cytoplasm
	Molecular Function	Transcription Corepressor Activity Signal Transducer Activity Protein Binding	NEDD8-specific Protease Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Signal Transduction Cell Proliferation Cullin Deneddylation Neuron Differentiation Skeletal Muscle Cell Differentiation	Protein Deneddylation Proteolysis
Pathways
Drugs
Diseases
GWAS			Metabolite levels (HVA/MHPG ratio) ( 23319000)
Protein-Protein Interactions		39 interactors: COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 CSNK2A1 CSNK2B CUL1 CUL4A CUL5 DDB1 EP300 GFER GPS1 HIST1H3A HIST1H4A ING1 ING2 IP6K1 IRF8 JUN MAP3K10 MAPK8 NCOR1 NIF3L1 NR0B1 NR2F1 PRKD1 PSMD4 RARA RXRA SENP8 SIN3A SIN3B THRA THRB TP53 VDR	12 interactors: COPS2 CUL1 CUL2 CUL4A GPS1 NEDD8 PLA2G2A SMURF1 UBB USP15 USP21 USP28
Entrez ID		9318	123228
HPRD ID		05146	09784
Ensembl ID		ENSG00000166200	ENSG00000166192
Uniprot IDs		P61201 Q59EL2	A8K8D3 Q96LD8
PDB IDs			1XT9 2BKQ 2BKR
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Cullin Deneddylation Negative Regulation Of Transcription, DNA-templated Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Protein Modification By Small Protein Removal Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Hormone-mediated Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Protein Metabolic Process Signal Transduction DNA-templated Transcription, Initiation Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Negative Regulation Of Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Signaling Cellular Response To Steroid Hormone Stimulus Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Regulation Of Protein Deacetylation Cellular Response To Lipid Metabolic Process Cell Communication Intracellular Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Cell Death Gene Expression	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Catabolic Process Protein Modification By Small Protein Removal Cellular Protein Modification Process Proteolysis Cellular Protein Metabolic Process Protein Modification By Small Protein Conjugation Apoptotic Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Protein Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Intrinsic Apoptotic Signaling Pathway Response To Transforming Growth Factor Beta Regulation Of Proteasomal Protein Catabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Ubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cullin Deneddylation Regulation Of Proteolysis Signal Transduction Protein Deneddylation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Deubiquitination Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cell Cycle Signaling Regulation Of Metabolic Process Cell Communication Regulation Of Protein Metabolic Process Cellular Metabolic Process Histone Deubiquitination Cell Cycle Arrest Negative Regulation Of Cell Cycle Response To Stimulus Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Programmed Cell Death Cell Cycle Process
Tagcloud ?			attributed bca3 bind conversely crucial cullins deacetylase du145 link mcf7 modification nad necrosis nedd8 neddylated neddylation nfkappab p65 prolongs protease recruit reversed silencing sirt1 span substrates ubiquitin worms yeast
Tagcloud (Difference) ?			attributed bca3 bind conversely crucial cullins deacetylase du145 link mcf7 modification nad necrosis nedd8 neddylated neddylation nfkappab p65 prolongs protease recruit reversed silencing sirt1 span substrates ubiquitin worms yeast
Tagcloud (Intersection) ?