LDHAL6B and PRMT6

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		LDHAL6B	PRMT6
Description		lactate dehydrogenase A like 6B	protein arginine methyltransferase 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Oxidoreductase Complex	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Catalytic Activity L-lactate Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor	Chromatin Binding Protein Binding Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone H4R3 Methyltransferase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone H3 Methyltransferase Activity
	Biological Process	Lactate Metabolic Process Carboxylic Acid Metabolic Process Pyruvate Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Base-excision Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Mitochondrion Organization Methylation Cellular Response To Stress Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Cellular Senescence Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Pyruvate metabolism	RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs		NADH
Diseases
GWAS			Adult body size ( 32376654) Blood pressure measurement (low sodium intervention) ( 24165912) Intelligence ( 22449649) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Refractive error ( 32231278) Response to SSRI in MDD or openness ( 29559929) Restless legs syndrome ( 29029846) Sex hormone-binding globulin levels ( 22829776) Waist circumference ( 28552196) Weight ( 28552196)
Interacting Genes		6 interacting genes: APPL2 HSH2D PRMT5 PRMT6 SOCS4 SUV39H1	90 interacting genes: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GPS2 GRHL3 GSTCD GTPBP2 H2AC18 H2BC21 H3-5 H3C14 H3C15 H4C16 H4C6 HESX1 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LINC02875 LOXL4 MALT1 MED28 METTL27 MLC1 MNDA MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PSMD11 PYCR3 PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WDFY3 ZNF436 ZNF557 ZSCAN9
Entrez ID		92483	55170
HPRD ID		13981	10505
Ensembl ID		ENSG00000171989	ENSG00000198890
Uniprot IDs		A0A140VJM9 Q9BYZ2	Q96LA8
PDB IDs			4HC4 4QPP 4QQK 4Y2H 4Y30 5E8R 5EGS 5HZM 5WCF 6P7I 6W6D 6WAD 7NR4
Enriched GO Terms of Interacting Partners?		Histone H3 Methyltransferase Activity Histone Methyltransferase Activity Histone Arginine N-methyltransferase Activity Histone H4R3 Methyltransferase Activity Protein-arginine N-methyltransferase Activity Methyltransferase Activity Methylation Negative Regulation Of Metabolic Process Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Histone H2AR3 Methyltransferase Activity Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Peptidyl-arginine N-methylation Dense Core Granule Membrane Negative Regulation Of Type 2 Mitophagy Histone H3R2 Methyltransferase Activity Positive Regulation Of Macropinocytosis ENoSc Complex Negative Regulation Of Macromolecule Metabolic Process Circadian Rhythm Protein-arginine Omega-N Symmetric Methyltransferase Activity Regulation Of Signal Transduction By P53 Class Mediator Early Phagosome Membrane Cold Acclimation Regulation Of Multicellular Organismal Development Histone H3K9 Trimethyltransferase Activity Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling RDNA Heterochromatin Positive Regulation Of Dopamine Receptor Signaling Pathway Peptidyl-arginine Methylation Protein Retention In Golgi Apparatus Protein-arginine Omega-N Monomethyltransferase Activity Macropinosome Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway RDNA Heterochromatin Formation Protein-arginine Omega-N Asymmetric Methyltransferase Activity Positive Regulation Of Pinocytosis Histone H3K9me2 Methyltransferase Activity Regulation Of Transcription By Glucose Chromatin Organization Regulation Of Cell Development Adiponectin-activated Signaling Pathway Negative Regulation Of Mitochondrial Depolarization Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Histone H3K9 Methyltransferase Activity Golgi Ribbon Formation Endothelial Cell Activation Diet Induced Thermogenesis Nuclear Lamina	Nucleus Structural Constituent Of Chromatin Protein Binding Nucleosome Nucleoplasm Chromatin Organization Nucleosome Organization Chromatin Remodeling Chromosome Senescence-associated Heterochromatin Focus
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?