LDHAL6B and SOCS4

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		LDHAL6B	SOCS4
Description		lactate dehydrogenase A like 6B	suppressor of cytokine signaling 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Oxidoreductase Complex
	Molecular Function	Catalytic Activity L-lactate Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor	Protein Binding
	Biological Process	Lactate Metabolic Process Carboxylic Acid Metabolic Process Pyruvate Catabolic Process	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction
Pathways		Pyruvate metabolism	RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Drugs		NADH
Diseases
GWAS			Low density lipoprotein cholesterol levels ( 33339817) Total cholesterol levels ( 33339817)
Interacting Genes		6 interacting genes: APPL2 HSH2D PRMT5 PRMT6 SOCS4 SUV39H1	11 interacting genes: CNMD EGFR LDHAL6B MDFIC NR4A1 PALS1 PLPP6 SPRY1 TEKT4 TNK2 VWF
Entrez ID		92483	122809
HPRD ID		13981	18084
Ensembl ID		ENSG00000171989	ENSG00000180008
Uniprot IDs		A0A140VJM9 Q9BYZ2	Q8WXH5
PDB IDs			2IZV
Enriched GO Terms of Interacting Partners?		Histone H3 Methyltransferase Activity Histone Methyltransferase Activity Histone Arginine N-methyltransferase Activity Histone H4R3 Methyltransferase Activity Protein-arginine N-methyltransferase Activity Methyltransferase Activity Methylation Negative Regulation Of Metabolic Process Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Histone H2AR3 Methyltransferase Activity Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Peptidyl-arginine N-methylation Dense Core Granule Membrane Negative Regulation Of Type 2 Mitophagy Histone H3R2 Methyltransferase Activity Positive Regulation Of Macropinocytosis ENoSc Complex Negative Regulation Of Macromolecule Metabolic Process Circadian Rhythm Protein-arginine Omega-N Symmetric Methyltransferase Activity Regulation Of Signal Transduction By P53 Class Mediator Early Phagosome Membrane Cold Acclimation Regulation Of Multicellular Organismal Development Histone H3K9 Trimethyltransferase Activity Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling RDNA Heterochromatin Positive Regulation Of Dopamine Receptor Signaling Pathway Peptidyl-arginine Methylation Protein Retention In Golgi Apparatus Protein-arginine Omega-N Monomethyltransferase Activity Macropinosome Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway RDNA Heterochromatin Formation Protein-arginine Omega-N Asymmetric Methyltransferase Activity Positive Regulation Of Pinocytosis Histone H3K9me2 Methyltransferase Activity Regulation Of Transcription By Glucose Chromatin Organization Regulation Of Cell Development Adiponectin-activated Signaling Pathway Negative Regulation Of Mitochondrial Depolarization Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Histone H3K9 Methyltransferase Activity Golgi Ribbon Formation Endothelial Cell Activation Diet Induced Thermogenesis Nuclear Lamina
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