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LONRF1 and SPRY2
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
LONRF1
SPRY2
Gene Name
LON peptidase N-terminal domain and ring finger 1
sprouty homolog 2 (Drosophila)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Microtubule
Plasma Membrane
Microtubule Cytoskeleton
Ruffle Membrane
Molecular Function
ATP-dependent Peptidase Activity
Zinc Ion Binding
Protein Binding
Protein Kinase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Protein Serine/threonine Kinase Activator Activity
Biological Process
Proteolysis
Establishment Of Mitotic Spindle Orientation
Epidermal Growth Factor Receptor Signaling Pathway
Sensory Perception Of Sound
Negative Regulation Of Cell Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Negative Regulation Of Peptidyl-threonine Phosphorylation
Positive Regulation Of Peptidyl-serine Phosphorylation
Negative Regulation Of Ras GTPase Activity
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Inner Ear Morphogenesis
Negative Regulation Of Apoptotic Process
Negative Regulation Of MAP Kinase Activity
Cell Fate Commitment
Negative Regulation Of Ras Protein Signal Transduction
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Protein Kinase B Signaling
Lung Growth
Bud Elongation Involved In Lung Branching
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways
Signaling by EGFR
EGFR downregulation
Signaling by FGFR in disease
Signaling by EGFR in Cancer
Signaling by Ligand-Responsive EGFR Variants in Cancer
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by EGFRvIII in Cancer
Spry regulation of FGF signaling
Signaling by FGFR
Negative regulation of FGFR signaling
Drugs
Diseases
GWAS
Adiposity (
21706003
)
Fasting insulin-related traits (interaction with BMI) (
22581228
)
Orofacial clefts (
20023658
22863734
)
Type 2 diabetes (
20862305
)
Protein-Protein Interactions
32 interactors:
ADAMTSL4
ALAS1
ATG9A
BRCA1
BYSL
CALCOCO2
CCDC36
CRX
EFHC2
GORASP1
GORASP2
IKZF2
IQCF2
KAT5
KCTD9
KRT31
KRTAP13-1
LHX4
NR4A1
PLSCR1
RBPMS
SFN
SPRY2
STAU1
STX11
TRIM42
TRIM9
UBE2L6
UCHL3
USP2
WDYHV1
XIAP
90 interactors:
ADAMTSL4
AQP1
ATRIP
C19orf66
CATSPER1
CBL
CBLB
CBLC
CHRD
CREB5
CRIP2
CRMP1
CSTB
CTSB
DGCR6
DNM2
EIF4E2
FAIM
FAM219A
FBN1
FRS3
GNE
GP9
GPRIN2
GRAP2
GRB2
HEXIM2
HSD3B7
ITSN1
KDM1A
KIF1A
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP4-11
KRTAP4-12
KRTAP4-7
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-4
LASP1
LCE1B
LCE2D
LCE3C
LCE3E
LCE4A
LONRF1
MAPKBP1
MDFI
MEOX2
MID2
MKNK1
MLLT6
NCK2
NEDD4
NR1H2
NUBP1
OTX1
PACSIN3
PLSCR1
PRKAB2
PTGER3
PTPN11
RAF1
RTFDC1
RUNX1T1
SDHB
SEMA5B
SH3KBP1
SIAH2
SPRY1
STK16
TCAF1
TRAF2
TRIM51
TXNDC5
UBASH3A
UBASH3B
UBR1
USP20
VPS25
VPS36
ZBTB16
ZNF266
ZNF417
ZNF587
Entrez ID
91694
10253
HPRD ID
08674
03916
Ensembl ID
ENSG00000154359
ENSG00000136158
Uniprot IDs
Q17RB8
O43597
PDB IDs
3BUM
3OB1
Enriched GO Terms of Interacting Partners
?
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
DNA Damage Response, Signal Transduction Resulting In Transcription
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity
Modification-dependent Protein Catabolic Process
Positive Regulation Of Protein Acetylation
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Protein Catabolic Process
Apoptotic Process
Negative Regulation Of Cell Death
Programmed Cell Death
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Apoptotic Process
Cell Death
Death
Negative Regulation Of Hydrolase Activity
Androgen Receptor Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Gene Expression
Intrinsic Apoptotic Signaling Pathway
Regulation Of Cell Death
Positive Regulation Of Histone H4-K20 Methylation
Positive Regulation Of Histone H4-K16 Acetylation
Positive Regulation Of Photoreceptor Cell Differentiation
Positive Regulation Of Cellular Metabolic Process
Intracellular Receptor Signaling Pathway
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Cysteine-type Endopeptidase Activity
Innate Immune Response
Negative Regulation Of Cellular Protein Metabolic Process
Synaptic Vesicle Exocytosis
Regulation Of Protein Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Medial Motor Column Neuron Differentiation
Positive Regulation Of Histone H3-K9 Acetylation
Negative Regulation Of SNARE Complex Assembly
Positive Regulation Of Protein Linear Polyubiquitination
Late Nucleophagy
Piecemeal Microautophagy Of Nucleus
Negative Regulation Of Protein Metabolic Process
Response To Stress
Positive Regulation Of Transcription, DNA-templated
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Metabolic Process
Positive Regulation Of Protein Modification Process
Regulation Of Viral Genome Replication
Negative Regulation Of Signaling
Regulation Of Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of ERBB Signaling Pathway
Keratinization
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of ERBB Signaling Pathway
Regulation Of Signaling
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Protein Metabolic Process
Regulation Of Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cellular Protein Metabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cellular Process
Keratinocyte Differentiation
Regulation Of Cell Activation
Negative Regulation Of Protein Metabolic Process
Fibroblast Growth Factor Receptor Signaling Pathway
Cell Death
System Development
Death
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Cell-cell Adhesion
Developmental Process
Multicellular Organismal Development
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Regulation Of T Cell Activation
Cellular Response To Organic Substance
Cell Differentiation
Anatomical Structure Development
Organ Development
Positive Regulation Of T Cell Activation
Positive Regulation Of Homotypic Cell-cell Adhesion
Protein Ubiquitination
Cellular Response To Growth Factor Stimulus
Regulation Of Protein Kinase Activity
Epidermal Cell Differentiation
Response To Growth Factor
Protein Modification By Small Protein Conjugation
Epithelium Development
Regulation Of Apoptotic Process
Regulation Of Cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Regulation Of Kinase Activity
Regulation Of Immune System Process
Negative Regulation Of Cellular Metabolic Process
Tagcloud
?
beyond
carcinogenesis
carcinogenic
cdh1
chfr
continue
detailed
endometrial
explained
familial
generations
germ
grow
hmlh1
hypermethylation
imbalance
inherited
involve
micrornas
mir
mismatch
mmr
oncogenes
pten
rassf1a
rsk4
unopposed
worldwide
younger
Tagcloud (Difference)
?
beyond
carcinogenesis
carcinogenic
cdh1
chfr
continue
detailed
endometrial
explained
familial
generations
germ
grow
hmlh1
hypermethylation
imbalance
inherited
involve
micrornas
mir
mismatch
mmr
oncogenes
pten
rassf1a
rsk4
unopposed
worldwide
younger
Tagcloud (Intersection)
?