LONRF1 and IKZF2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		LONRF1	IKZF2
Gene Name		LON peptidase N-terminal domain and ring finger 1	IKAROS family zinc finger 2 (Helios)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus
	Molecular Function	ATP-dependent Peptidase Activity Zinc Ion Binding	Molecular_function DNA Binding Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Proteolysis	Transcription, DNA-templated Biological_process Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS			Eosinophil counts ( 19198610)
Protein-Protein Interactions		32 interactors: ADAMTSL4 ALAS1 ATG9A BRCA1 BYSL CALCOCO2 CCDC36 CRX EFHC2 GORASP1 GORASP2 IKZF2 IQCF2 KAT5 KCTD9 KRT31 KRTAP13-1 LHX4 NR4A1 PLSCR1 RBPMS SFN SPRY2 STAU1 STX11 TRIM42 TRIM9 UBE2L6 UCHL3 USP2 WDYHV1 XIAP	9 interactors: AQP1 CTBP1 CTBP2 HDAC4 HOXA1 IKZF1 IKZF4 IKZF5 LONRF1
Entrez ID		91694	22807
HPRD ID		08674	05872
Ensembl ID		ENSG00000154359	ENSG00000030419
Uniprot IDs		Q17RB8	B4DWF2 Q9UKS7
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Acetylation Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Protein Catabolic Process Apoptotic Process Negative Regulation Of Cell Death Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Apoptotic Process Cell Death Death Negative Regulation Of Hydrolase Activity Androgen Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Gene Expression Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Death Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Positive Regulation Of Photoreceptor Cell Differentiation Positive Regulation Of Cellular Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Synaptic Vesicle Exocytosis Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Medial Motor Column Neuron Differentiation Positive Regulation Of Histone H3-K9 Acetylation Negative Regulation Of SNARE Complex Assembly Positive Regulation Of Protein Linear Polyubiquitination Late Nucleophagy Piecemeal Microautophagy Of Nucleus Negative Regulation Of Protein Metabolic Process Response To Stress Positive Regulation Of Transcription, DNA-templated Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Viral Genome Replication	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter White Fat Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Biosynthetic Process RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Viral Genome Replication Gene Expression Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Response To Retinoic Acid Regulation Of Gene Expression Positive Regulation Of Neutrophil Differentiation Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development Abducens Nerve Formation Maintenance Of Symbiont-containing Vacuole By Host Transepithelial Water Transport Optokinetic Behavior Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process B Cell Differentiation Facial Nucleus Development Carbon Dioxide Transmembrane Transport Corticotropin Secretion Establishment Or Maintenance Of Actin Cytoskeleton Polarity
Tagcloud ?			aggressive aiolos alterations aneuploidy chromosomes commonly differ encoding exome explored haploid harbor helios hypodiploid ikzf3 leukemic lymphoblastic lymphoid near nontumor phosphoinositide pi3k profiles profiling ras rb1 submicroscopic subtype tp53
Tagcloud (Difference) ?			aggressive aiolos alterations aneuploidy chromosomes commonly differ encoding exome explored haploid harbor helios hypodiploid ikzf3 leukemic lymphoblastic lymphoid near nontumor phosphoinositide pi3k profiles profiling ras rb1 submicroscopic subtype tp53
Tagcloud (Intersection) ?