MAP3K2 and SMURF1

Number of citations of the paper that reports this interaction (PMID 15820682)
71

Data Source:
HPRD (in vivo, two hybrid)

		MAP3K2	SMURF1
Gene Name		mitogen-activated protein kinase kinase kinase 2	SMAD specific E3 ubiquitin protein ligase 1
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Axon Neuronal Cell Body Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Activin Binding Ubiquitin Protein Ligase Activity I-SMAD Binding R-SMAD Binding
	Biological Process	Activation Of MAPKK Activity Activation Of MAPK Activity Protein Phosphorylation Activation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Cellular Response To Mechanical Stimulus	Protein Polyubiquitination Protein Export From Nucleus Transforming Growth Factor Beta Receptor Signaling Pathway Ectoderm Development Protein Ubiquitination Cell Differentiation Negative Regulation Of Ossification BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Receptor Catabolic Process Protein Localization To Cell Surface Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways			Loss of Function of TGFBR2 in Cancer Antigen processing: Ubiquitination & Proteasome degradation Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs Signaling by Wnt TGFBR1 LBD Mutants in Cancer Signaling by BMP Hedgehog 'on' state Class I MHC mediated antigen processing & presentation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer beta-catenin independent WNT signaling Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Asymmetric localization of PCP proteins Signaling by Hedgehog PCP/CE pathway SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 20228798)
Protein-Protein Interactions		25 interactors: BIRC2 IKBKG MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K3 MAP3K5 MAPK8 NEDD4 NEDD4L NFKBIA PIBF1 PKN2 SH2D2A SMURF1 STAMBP STUB1 UBC USP2 WNK1 XIAP YWHAE YWHAG YWHAZ	98 interactors: ANAPC5 AP2B1 APBB2 APP ARHGAP15 ARHGAP31 ARHGEF9 ARL14 ARL4D ASH2L AVEN AXIN1 CCM2 CDC40 CDK14 CDKL1 CSNK2A2 CUL5 CXXC1 DNAJC7 DUSP13 DVL2 ECSIT ELP3 ESR1 ETV6 FBXL15 FBXO30 FCHO1 GNG11 GRIPAP1 HDGFRP3 ING2 INPP5B IRAK2 JUNB LATS1 LHX9 LIMS1 LONRF3 MAP3K2 MAP3K3 NAA16 NDFIP2 NEDD8 OXSR1 PAK1 PAK1IP1 PDLIM7 PLEKHO1 POLR2A PSME3 PWP1 RASD2 RHOA RHPN2 RIPK2 RIT1 RNF11 RNF141 RPS27A RRP9 RTKN RUNX3 SASH3 SENP8 SF3A1 SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SPG20 SQSTM1 SRSF4 SRSF5 STK35 STRAP STUB1 TLN1 TNK2 TNNT1 TRAF4 TTC17 UBA52 UBB UBC UBE2D3 UBE2L3 UBTF UBXN1 USP45 USP9X WDR61 WEE1 WFS1 XPO1
Entrez ID		10746	57154
HPRD ID		10068	06902
Ensembl ID		ENSG00000169967	ENSG00000198742
Uniprot IDs		Q9Y2U5	Q9HCE7
PDB IDs		2CU1 2NPT	2LAZ 2LB0 2LB1 2LTX 3PYC
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Signal Transduction Intracellular Signal Transduction Apoptotic Process Toll-like Receptor 5 Signaling Pathway Programmed Cell Death Toll-like Receptor 10 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Signaling Toll-like Receptor Signaling Pathway Cell Death Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Death Cell Communication Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway MAPK Cascade Activation Of MAPK Activity Activation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Innate Immune Response Cellular Response To Stimulus Signal Transduction By Phosphorylation Positive Regulation Of Innate Immune Response Response To Stimulus Regulation Of Apoptotic Process Cellular Protein Modification Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Cell Death Positive Regulation Of MAP Kinase Activity Activation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity JNK Cascade Regulation Of MAP Kinase Activity Positive Regulation Of Protein Modification Process Cellular Response To Stress Regulation Of Catalytic Activity	Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Signal Transduction Cellular Protein Modification Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Protein Metabolic Process Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Cellular Response To Organic Substance Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Signal Transduction Signaling Positive Regulation Of Metabolic Process Cell Communication Cellular Response To Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Transferase Activity Negative Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Signaling Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Phosphorylation Transcription From RNA Polymerase II Promoter Protein Catabolic Process Regulation Of Cellular Process Transcription Initiation From RNA Polymerase II Promoter Proteolysis Involved In Cellular Protein Catabolic Process DNA-templated Transcription, Initiation Cellular Protein Catabolic Process Response To Organic Substance Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Metabolic Process Positive Regulation Of Ligase Activity Response To Stimulus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Gene Expression
Tagcloud ?			5p acvr2a alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 systematically tgfbr3 zfp423
Tagcloud (Difference) ?			5p acvr2a alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 systematically tgfbr3 zfp423
Tagcloud (Intersection) ?