MAP3K2 and SH2D2A

Number of citations of the paper that reports this interaction (PubMedID 12640115)
61

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		MAP3K2	SH2D2A
Description		mitogen-activated protein kinase kinase kinase 2	SH2 domain containing 2A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity	Protein Binding SH3 Domain Binding
	Biological Process	MAPK Cascade Intracellular Signal Transduction Cellular Response To Mechanical Stimulus	Angiogenesis Signal Transduction Cell Differentiation T Cell Proliferation
Pathways			VEGFA-VEGFR2 Pathway
Drugs		Bosutinib Fostamatinib
Diseases
GWAS		Protein C levels ( 28082259)	Autoimmune thyroid disease ( 32581359) Platelet count ( 27863252 32888494) Plateletcrit ( 32888494) Sjögren's syndrome ( 28076899)
Interacting Genes		27 interacting genes: BIRC2 CTNNB1 IKBKG ITCH LATS1 MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAPK8 NEDD4 NFKBIA PIBF1 PKN2 SH2D2A SMURF1 SMYD3 STAMBP STUB1 USP2 WNK1 XIAP YAP1 YWHAE YWHAG YWHAZ	34 interacting genes: APPL1 AR ARID5A CRK DAPK1 EGFR ERBB2 ERBB3 ERBB4 GAB1 ITK KDR KIT LCK LINC02875 LNX1 LRRFIP1 LRRK1 MAP3K2 MAPK7 MET MFHAS1 NAA16 PLCG1 PPP1R21 SOCS3 SPTB STAT3 SYK TSC1 TXK VCP ZHX3 ZSCAN1
Entrez ID		10746	9047
HPRD ID		10068	05152
Ensembl ID		ENSG00000169967	ENSG00000027869
Uniprot IDs		Q9Y2U5	Q5UBZ2 Q5UBZ3 Q9NP31
PDB IDs		2CU1 2NPT 5EX0 5HQ8 6LDV 6LDW 6LDX 6LDY
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction MAPK Cascade Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Cellular Response To Stress Signal Transduction Protein Modification Process Positive Regulation Of Protein Metabolic Process Cytosol Protein Polyubiquitination Cytoplasm Regulation Of Apoptotic Process Negative Regulation Of Intracellular Signal Transduction Transferase Activity Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Post-translational Protein Modification Protein Serine Kinase Activity Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Surface Receptor Signaling Pathway MAP Kinase Kinase Activity Protein Phosphatase Binding Protein Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Immune Response Response To Stress Immune Response-regulating Signaling Pathway Regulation Of Protein Modification Process Regulation Of Immune System Process Positive Regulation Of Signal Transduction Cellular Senescence Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Protein Domain Specific Binding Protein Kinase Activity Stress-activated Protein Kinase Signaling Cascade Phosphoserine Residue Binding Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Modification-dependent Protein Catabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway	Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Signal Transduction ATP Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Proliferation Nucleotide Binding Signal Transduction Regulation Of Intracellular Signal Transduction ERBB Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of MAPK Cascade Regulation Of Signaling Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Programmed Cell Death Transferase Activity Cellular Response To Growth Factor Stimulus Cellular Developmental Process Negative Regulation Of Programmed Cell Death Receptor Complex Cell Differentiation ERBB2 Signaling Pathway Protein Autophosphorylation Response To Growth Factor Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Basal Plasma Membrane Protein Phosphorylation Regulation Of Epithelial Cell Proliferation Protein Phosphatase Binding Negative Regulation Of Defense Response SH2 Domain Binding Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Inflammatory Response Growth Factor Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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