MAP3K2 and BIRC2

Number of citations of the paper that reports this interaction (PMID 24975362)
0

Data Source:
BioGRID (enzymatic study)

		MAP3K2	BIRC2
Gene Name		mitogen-activated protein kinase kinase kinase 2	baculoviral IAP repeat containing 2
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	XY Body Nucleus Cytoplasm Cytosol Spindle Microtubule Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Membrane Raft
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein N-terminus Binding
	Biological Process	Activation Of MAPKK Activity Activation Of MAPK Activity Protein Phosphorylation Activation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Cellular Response To Mechanical Stimulus	Protein Polyubiquitination Response To Hypoxia Placenta Development Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Surface Receptor Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Regulation Of RIG-I Signaling Pathway Regulation Of Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Innate Immune Response Response To Ethanol Regulation Of Cell Differentiation Regulation Of Inflammatory Response Protein Heterooligomerization Response To CAMP Regulation Of Cell Cycle Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Necroptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Mitotic Spindle Assembly Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Apoptotic cleavage of cellular proteins IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling Apoptotic execution phase MyD88-independent cascade Activated TLR4 signalling Toll-Like Receptors Cascades Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Programmed Cell Death Innate Immune System
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		25 interactors: BIRC2 IKBKG MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K3 MAP3K5 MAPK8 NEDD4 NEDD4L NFKBIA PIBF1 PKN2 SH2D2A SMURF1 STAMBP STUB1 UBC USP2 WNK1 XIAP YWHAE YWHAG YWHAZ	58 interactors: BIRC5 BIRC7 BOLA1 CASP2 CASP3 CASP7 CASP9 CBLC CD40 DIABLO DZIP3 EAF2 EXOSC5 FBXO7 GAS1 GCC1 GFAP GSPT1 HSP90B1 HTRA2 IKBKE IKBKG JUP LTBR MAGEA11 MAP3K2 MAP3K3 NMB OTUB1 PACS2 PCSK9 PPM1K RAC1 RAF1 RHOA RIPK1 RIPK2 RIPK3 RIPK4 RNF181 TRADD TRAF1 TRAF2 TRIM34 TSG101 TSGA10 UBB UBC UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2J1 UBE2Q2 UBE2S UBE2V1 UBE2W WDYHV1
Entrez ID		10746	329
HPRD ID		10068	03419
Ensembl ID		ENSG00000169967	ENSG00000110330
Uniprot IDs		Q9Y2U5	Q13490
PDB IDs		2CU1 2NPT	1QBH 2L9M 3D9T 3D9U 3M1D 3MUP 3OZ1 3T6P 3UW4 4EB9 4HY4 4HY5 4LGE 4LGU
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Signal Transduction Intracellular Signal Transduction Apoptotic Process Toll-like Receptor 5 Signaling Pathway Programmed Cell Death Toll-like Receptor 10 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Signaling Toll-like Receptor Signaling Pathway Cell Death Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Death Cell Communication Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway MAPK Cascade Activation Of MAPK Activity Activation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Innate Immune Response Cellular Response To Stimulus Signal Transduction By Phosphorylation Positive Regulation Of Innate Immune Response Response To Stimulus Regulation Of Apoptotic Process Cellular Protein Modification Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Cell Death Positive Regulation Of MAP Kinase Activity Activation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity JNK Cascade Regulation Of MAP Kinase Activity Positive Regulation Of Protein Modification Process Cellular Response To Stress Regulation Of Catalytic Activity	Programmed Cell Death Cell Death Death Apoptotic Process Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Activation Of Innate Immune Response Regulation Of Protein Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Innate Immune Response Protein Ubiquitination Cellular Response To Stress Regulation Of Cell Death Protein Modification By Small Protein Conjugation Positive Regulation Of Cellular Protein Metabolic Process Protein Polyubiquitination Protein Processing Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Signal Transduction Protein Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cell Death Protein Catabolic Process Cellular Macromolecule Catabolic Process Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Transferase Activity Response To Stress Cellular Protein Catabolic Process Cellular Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Cellular Protein Metabolic Process
Tagcloud ?			2b arrest baculoviral c4 caspases cdk2 ciap1 consumer deacetylases dependently du ester hdacs immortalized lncap maa malformation methoxyacetic named p63 p73 pharmaceutical phthalates prns prostatic rwpe spermatocyte suppresses turning
Tagcloud (Difference) ?			2b arrest baculoviral c4 caspases cdk2 ciap1 consumer deacetylases dependently du ester hdacs immortalized lncap maa malformation methoxyacetic named p63 p73 pharmaceutical phthalates prns prostatic rwpe spermatocyte suppresses turning
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