MAP3K2 and MAP2K4

Number of citations of the paper that reports this interaction (PMID 7997270)
142

Data Source:
HPRD (in vitro)

		MAP3K2	MAP2K4
Gene Name		mitogen-activated protein kinase kinase kinase 2	mitogen-activated protein kinase kinase 4
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Intracellular Nucleus Cytosol Axon Dendrite Cytoplasm Perikaryon
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding
	Biological Process	Activation Of MAPKK Activity Activation Of MAPK Activity Protein Phosphorylation Activation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Cellular Response To Mechanical Stimulus	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Signal Transduction JNK Cascade Activation Of JUN Kinase Activity Pathogenesis Peptidyl-tyrosine Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Positive Regulation Of DNA Replication Stress-activated MAPK Cascade Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Mechanical Stimulus Cellular Response To Sorbitol
Pathways			Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Uptake and actions of bacterial toxins MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Uptake and function of anthrax toxins Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Oxidative Stress Induced Senescence Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling
Drugs
Diseases
GWAS			Response to amphetamines ( 22952603)
Protein-Protein Interactions		25 interactors: BIRC2 IKBKG MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K3 MAP3K5 MAPK8 NEDD4 NEDD4L NFKBIA PIBF1 PKN2 SH2D2A SMURF1 STAMBP STUB1 UBC USP2 WNK1 XIAP YWHAE YWHAG YWHAZ	37 interactors: AKT1 APP ARRB1 ARRB2 CFLAR DUSP22 EFNA4 FLNA FLNC GEMIN5 ITCH JUN LRRK2 MAP2K6 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K14 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K8 MAP4K2 MAPK1 MAPK10 MAPK12 MAPK14 MAPK8 MAPK8IP3 MAPK9 RBBP8 SPAG9 TRIB1 ZAK
Entrez ID		10746	6416
HPRD ID		10068	03213
Ensembl ID		ENSG00000169967	ENSG00000065559
Uniprot IDs		Q9Y2U5	B7ZA62 P45985
PDB IDs		2CU1 2NPT	3ALN 3ALO 3VUT
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Signal Transduction Intracellular Signal Transduction Apoptotic Process Toll-like Receptor 5 Signaling Pathway Programmed Cell Death Toll-like Receptor 10 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Signaling Toll-like Receptor Signaling Pathway Cell Death Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Death Cell Communication Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway MAPK Cascade Activation Of MAPK Activity Activation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Innate Immune Response Cellular Response To Stimulus Signal Transduction By Phosphorylation Positive Regulation Of Innate Immune Response Response To Stimulus Regulation Of Apoptotic Process Cellular Protein Modification Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Cell Death Positive Regulation Of MAP Kinase Activity Activation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity JNK Cascade Regulation Of MAP Kinase Activity Positive Regulation Of Protein Modification Process Cellular Response To Stress Regulation Of Catalytic Activity	MAPK Cascade Signal Transduction By Phosphorylation Regulation Of MAPK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of MAPK Cascade Activation Of MAPK Activity Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Activation Of Protein Kinase Activity Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process JNK Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Activation Of MAPKK Activity Positive Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Kinase Activity Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Phosphorylation Regulation Of Signaling Regulation Of JNK Cascade Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Intracellular Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Phosphate-containing Compound Metabolic Process Positive Regulation Of JUN Kinase Activity Cell Death Death Positive Regulation Of JNK Cascade Regulation Of JUN Kinase Activity
Tagcloud ?			aurka aurkb bioinformatics cdkn2a copy custom describing epha5 flt4 frameshift insertions interrogating kdm6a leiomyosarcomas locally losses multiplexed nf1 ngs notch1 pdgfrb pik3ca pipeline rationale rb1 sarcomas soft stratification targetable
Tagcloud (Difference) ?			aurka aurkb bioinformatics cdkn2a copy custom describing epha5 flt4 frameshift insertions interrogating kdm6a leiomyosarcomas locally losses multiplexed nf1 ngs notch1 pdgfrb pik3ca pipeline rationale rb1 sarcomas soft stratification targetable
Tagcloud (Intersection) ?