SIAH2 and POU2AF1

Number of citations of the paper that reports this interaction (PMID 11483518)
21

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SIAH2	POU2AF1
Gene Name		siah E3 ubiquitin protein ligase 2	POU class 2 associating factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Early Endosome Cytosol Neuron Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle	Nucleus
	Molecular Function	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Conjugating Enzyme Binding	DNA Binding Transcription Cofactor Activity Transcription Coactivator Activity Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Small GTPase Mediated Signal Transduction Axon Guidance Protein Ubiquitination Regulation Of Protein Ubiquitination Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Humoral Immune Response
Pathways		Axon guidance Netrin-1 signaling
Drugs
Diseases
GWAS		Breast cancer ( 22951594)	Corneal structure ( 23291589) Primary biliary cirrhosis ( 23000144)
Protein-Protein Interactions		39 interactors: AFF1 ATN1 CACYBP CCBE1 DCC DYRK2 EEF1D EGLN3 HIPK2 HIPK3 MYD88 OPRM1 PEG10 PEG3 PIAS1 PIAS2 PIAS3 PML POU2AF1 PSMD4 RBBP8 SETD2 SNCA SNCAIP SPRY2 STAT3 SYP TINF2 TP53BP2 TPX2 TRAF2 UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2L6 USP13 USP19 VAV1	16 interactors: GATA2 GTF2H1 GTF2I MSX2 NAB1 PAX8 POU2F1 POU2F2 RHOXF2 SIAH1 SIAH2 SLC22A1 SLC22A2 SMAD2 SUB1 SYK
Entrez ID		6478	5450
HPRD ID		03737	03126
Ensembl ID		ENSG00000181788	ENSG00000110777
Uniprot IDs		O43255	Q16633
PDB IDs			1CQT
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Apoptotic Process Regulation Of Metabolic Process Programmed Cell Death Cell Death Regulation Of Cellular Process Death Positive Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Transcription, DNA-templated Cellular Response To Stress Regulation Of Protein Metabolic Process Response To Growth Factor Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Modification-dependent Protein Catabolic Process Protein Sumoylation Response To Organic Substance Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Proteasomal Protein Catabolic Process Cellular Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Stress Negative Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Innate Immune Response Positive Regulation Of Proteolysis Regulation Of Cell Death Immune Response Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Organic Substance Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Defense Response Negative Regulation Of Biosynthetic Process Regulation Of Proteolysis Toll-like Receptor Signaling Pathway	Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Organ Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Regulation Of Metabolic Process Anatomical Structure Morphogenesis RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Cell Differentiation Ammonium Transport Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Quaternary Ammonium Group Transport Negative Regulation Of RNA Biosynthetic Process System Development Cell Development Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Monoamine Transport Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Response To Stimulus Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Differentiation Transcription Initiation From RNA Polymerase II Promoter Drug Transmembrane Transport Signal Transduction Involved In Regulation Of Gene Expression Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Secretion By Cell Organ Development Positive Regulation Of BMP Signaling Pathway Anatomical Structure Development Ammonium Transmembrane Transport
Tagcloud ?		adding complexity decisions determines e3 fail fate favoring feedback finger hipk2 homeodomain inactivated interferes ligase loop preferentially proline stimulates switch termination ubiquitin ubiquitination uncovers waf1 xaf1 xiap zinc znf313
Tagcloud (Difference) ?		adding complexity decisions determines e3 fail fate favoring feedback finger hipk2 homeodomain inactivated interferes ligase loop preferentially proline stimulates switch termination ubiquitin ubiquitination uncovers waf1 xaf1 xiap zinc znf313
Tagcloud (Intersection) ?