SIAH2 and ATN1

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SIAH2	ATN1
Gene Name		siah E3 ubiquitin protein ligase 2	atrophin 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Early Endosome Cytosol Neuron Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Conjugating Enzyme Binding	Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Toxin Receptor Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Small GTPase Mediated Signal Transduction Axon Guidance Protein Ubiquitination Regulation Of Protein Ubiquitination Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Central Nervous System Development Toxin Metabolic Process Cell Migration Maintenance Of Cell Polarity Neuron Apoptotic Process
Pathways		Axon guidance Netrin-1 signaling
Drugs
Diseases
GWAS		Breast cancer ( 22951594)
Protein-Protein Interactions		39 interactors: AFF1 ATN1 CACYBP CCBE1 DCC DYRK2 EEF1D EGLN3 HIPK2 HIPK3 MYD88 OPRM1 PEG10 PEG3 PIAS1 PIAS2 PIAS3 PML POU2AF1 PSMD4 RBBP8 SETD2 SNCA SNCAIP SPRY2 STAT3 SYP TINF2 TP53BP2 TPX2 TRAF2 UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2L6 USP13 USP19 VAV1	93 interactors: AES AGRN ALG13 ARF3 ATRX BAG6 BAIAP2 CACNB1 CASP1 CASP3 CBFA2T2 CENPJ CHRD CRACR2A CRIP2 CTNND2 DMPK DVL1 DVL2 ECM1 EFEMP1 EFEMP2 EWSR1 FBLN1 FBLN2 FBLN5 GAPDH GCC1 GIGYF1 GRN HINFP HSPG2 ITCH JAG2 KAT6A KAT6B KAT7 KRT31 KRTAP4-12 LENG8 LRP2 LTBP1 LTBP4 LYST MAGI1 MAGI2 MAP7D1 MBP MDFI MEGF11 MEGF6 MEGF8 NCK2 NELL1 NELL2 NOC2L NR2E1 PCSK5 PDCD6IP PFKL PLSCR1 PRRC2A PRRC2B PSMA3 PSME3 RAD54L2 RBFOX1 RBFOX2 RBM10 RBPMS RCHY1 RERE RHOXF2 RNF115 RNF31 RUNX1T1 SIAH1 SIAH2 SLIT1 SPAG5 SSPO STXBP4 SYVN1 TEP1 TLE1 TRIP6 USP54 VIM WDR5 WWP1 WWP2 ZMYND8 ZSWIM8
Entrez ID		6478	1822
HPRD ID		03737	06311
Ensembl ID		ENSG00000181788	ENSG00000111676
Uniprot IDs		O43255	P54259 Q86V38
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Apoptotic Process Regulation Of Metabolic Process Programmed Cell Death Cell Death Regulation Of Cellular Process Death Positive Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Transcription, DNA-templated Cellular Response To Stress Regulation Of Protein Metabolic Process Response To Growth Factor Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Modification-dependent Protein Catabolic Process Protein Sumoylation Response To Organic Substance Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Proteasomal Protein Catabolic Process Cellular Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Stress Negative Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Innate Immune Response Positive Regulation Of Proteolysis Regulation Of Cell Death Immune Response Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Organic Substance Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Defense Response Negative Regulation Of Biosynthetic Process Regulation Of Proteolysis Toll-like Receptor Signaling Pathway	Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Multicellular Organismal Development Regulation Of Nitrogen Compound Metabolic Process Developmental Process Regulation Of Gene Expression Signaling Regulation Of Signaling Signal Transduction Nervous System Development Anatomical Structure Development Cell Communication Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Cellular Response To Stimulus Proteolysis Involved In Cellular Protein Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Cellular Protein Catabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Proteolysis Regulation Of RNA Biosynthetic Process System Development Response To Stimulus Cell Death Death Ubiquitin-dependent Protein Catabolic Process Anatomical Structure Morphogenesis Modification-dependent Protein Catabolic Process Protein Catabolic Process Apoptotic Process Negative Regulation Of Wnt Signaling Pathway Programmed Cell Death Regulation Of Transcription, DNA-templated Regulation Of Signal Transduction Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Biosynthetic Process Protein Ubiquitination Axon Development
Tagcloud ?		adding complexity decisions determines e3 fail fate favoring feedback finger hipk2 homeodomain inactivated interferes ligase loop preferentially proline stimulates switch termination ubiquitin ubiquitination uncovers waf1 xaf1 xiap zinc znf313	atrophin1 atrophy chip cortical degenerative demethylase dentatorubral depletion h3k4 hint inducing knockout lbal lsd1 lysine maintenance methylation npc pallidoluysian phenocopied poorly precise premature progenitor repression rescued seq surprisingly tranylcypromine
Tagcloud (Difference) ?		adding complexity decisions determines e3 fail fate favoring feedback finger hipk2 homeodomain inactivated interferes ligase loop preferentially proline stimulates switch termination ubiquitin ubiquitination uncovers waf1 xaf1 xiap zinc znf313	atrophin1 atrophy chip cortical degenerative demethylase dentatorubral depletion h3k4 hint inducing knockout lbal lsd1 lysine maintenance methylation npc pallidoluysian phenocopied poorly precise premature progenitor repression rescued seq surprisingly tranylcypromine
Tagcloud (Intersection) ?