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SIAH2 and SYP
Number of citations of the paper that reports this interaction (PubMedID
11786535
)
0
Data Source:
HPRD
(in vitro, in vivo)
SIAH2
SYP
Description
siah E3 ubiquitin protein ligase 2
synaptophysin
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Early Endosome
Cytosol
Neuronal Cell Body
Synaptic Vesicle
Membrane
Synaptic Vesicle Membrane
Cytoplasmic Vesicle
Neuromuscular Junction
Presynaptic Membrane
Neuron Projection
Terminal Bouton
Neuron Projection Terminus
Synapse
Perinuclear Region Of Cytoplasm
Presynaptic Active Zone
Excitatory Synapse
Schaffer Collateral - CA1 Synapse
Presynapse
Molecular Function
Transcription Corepressor Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Ubiquitin Conjugating Enzyme Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Protein Binding
Cholesterol Binding
SH2 Domain Binding
Identical Protein Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Small GTPase-mediated Signal Transduction
Protein Ubiquitination
Regulation Of Protein Ubiquitination
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of DNA-templated Transcription
Rhythmic Process
Canonical Wnt Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Amyloid Fibril Formation
Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Endocytosis
Regulation Of Synaptic Vesicle Priming
Synaptic Vesicle Maturation
Regulation Of Neuronal Synaptic Plasticity
Regulation Of Long-term Neuronal Synaptic Plasticity
Regulation Of Short-term Neuronal Synaptic Plasticity
Synaptic Vesicle Membrane Organization
Modulation Of Chemical Synaptic Transmission
Regulation Of Opioid Receptor Signaling Pathway
Pathways
Netrin-1 signaling
Ub-specific processing proteases
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Sensory processing of sound by inner hair cells of the cochlea
Drugs
Diseases
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS
BRCA1/2-negative high-risk breast cancer (
30323354
)
Breast cancer (
22951594
31757997
)
Interacting Genes
46 interacting genes:
AFF1
AKR1C3
ATN1
CACYBP
CCAR2
CCBE1
CHEK2
DCC
DLST
DYRK2
EEF1D
EGLN3
HIPK2
HIPK3
LATS2
MYD88
NRF1
OPRM1
PEG10
PEG3
PIAS2
PIAS3
PML
POU2AF1
PSMD4
RBBP8
SETD2
SNCA
SNCAIP
SPRY2
STAT3
SYP
TINF2
TP53BP2
TPX2
TRAF2
UBE2D1
UBE2D2
UBE2D3
UBE2I
UBE2L6
UBE2N
UBE2V2
USP13
USP19
VAV1
41 interacting genes:
AP1G1
ARFIP2
CAND2
CD160
DIABLO
FARS2
GAB1
GDNF
GRB2
HSFX1
HSFX2
JOSD2
LNPK
MIEF1
MIEF2
MRM1
MRRF
MTERF3
MYG1
NDRG4
PBX3
PITPNC1
PLIN3
PNKP
PPIF
PTCD1
PTPN9
RBFA
SH3GLB1
SIAH1
SIAH2
SMG9
SNX1
SPG21
SSX5
STARD4
THAP4
TUFM
VAMP2
WDFY2
WIPI2
Entrez ID
6478
6855
HPRD ID
03737
02435
Ensembl ID
ENSG00000181788
ENSG00000102003
Uniprot IDs
O43255
P08247
PDB IDs
5H9M
Enriched GO Terms of Interacting Partners
?
Cell Death
Nucleoplasm
Apoptotic Process
Programmed Cell Death
Nucleus
Regulation Of Primary Metabolic Process
Protein Modification Process
Post-translational Protein Modification
Regulation Of Metabolic Process
Protein Modification By Small Protein Conjugation
Ubiquitin Conjugating Enzyme Activity
Regulation Of Macromolecule Metabolic Process
Protein Polyubiquitination
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
SUMO Transferase Activity
Positive Regulation Of Metabolic Process
Cellular Response To Stress
Protein Metabolic Process
PML Body
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Macromolecule Metabolic Process
Transferase Activity
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cellular Response To Stress
Ubiquitin Protein Ligase Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Intracellular Signal Transduction
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of RNA Metabolic Process
Cytosol
Negative Regulation Of Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
DNA Damage Response
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Protein Modification Process
Intrinsic Apoptotic Signaling Pathway
Signal Transduction By P53 Class Mediator
Proteolysis Involved In Protein Catabolic Process
Protein Sumoylation
Negative Regulation Of Signal Transduction
Regulation Of Macromolecule Biosynthetic Process
Macromolecule Catabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Natural Killer Cell Degranulation
Dorsal Spinal Cord Development
Mitochondrion
Mitochondrial Matrix
Mitochondrial Outer Membrane
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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