SIAH2 and PEG3

Number of citations of the paper that reports this interaction (PubMedID 10681424)
25

Data Source:
HPRD (two hybrid, in vivo)

		SIAH2	PEG3
Description		siah E3 ubiquitin protein ligase 2	paternally expressed 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Early Endosome Cytosol Neuronal Cell Body	Nucleus Cytoplasm Autophagosome
	Molecular Function	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Zinc Ion Binding Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Small GTPase-mediated Signal Transduction Protein Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Rhythmic Process Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Amyloid Fibril Formation Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Apoptotic Process Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Netrin-1 signaling Ub-specific processing proteases Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 22951594 31757997)	Urate levels in lean individuals ( 25811787)
Interacting Genes		46 interacting genes: AFF1 AKR1C3 ATN1 CACYBP CCAR2 CCBE1 CHEK2 DCC DLST DYRK2 EEF1D EGLN3 HIPK2 HIPK3 LATS2 MYD88 NRF1 OPRM1 PEG10 PEG3 PIAS2 PIAS3 PML POU2AF1 PSMD4 RBBP8 SETD2 SNCA SNCAIP SPRY2 STAT3 SYP TINF2 TP53BP2 TPX2 TRAF2 UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2L6 UBE2N UBE2V2 USP13 USP19 VAV1	7 interacting genes: APP BRCA1 LIMS1 SIAH1 SIAH2 TRAF2 USP7
Entrez ID		6478	5178
HPRD ID		03737	03285
Ensembl ID		ENSG00000181788	ENSG00000198300
Uniprot IDs		O43255	A0A3B3IRU6 Q9GZU2
PDB IDs		5H9M	4BHX
Enriched GO Terms of Interacting Partners?		Cell Death Nucleoplasm Apoptotic Process Programmed Cell Death Nucleus Regulation Of Primary Metabolic Process Protein Modification Process Post-translational Protein Modification Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Regulation Of Macromolecule Metabolic Process Protein Polyubiquitination Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process SUMO Transferase Activity Positive Regulation Of Metabolic Process Cellular Response To Stress Protein Metabolic Process PML Body Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Macromolecule Metabolic Process Transferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress Ubiquitin Protein Ligase Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of RNA Metabolic Process Cytosol Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling DNA Damage Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Modification Process Intrinsic Apoptotic Signaling Pathway Signal Transduction By P53 Class Mediator Proteolysis Involved In Protein Catabolic Process Protein Sumoylation Negative Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Macromolecule Catabolic Process Negative Regulation Of Macromolecule Metabolic Process	Amyloid Fibril Formation Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Regulation Of Signal Transduction Post-translational Protein Modification Ubiquitin Protein Ligase Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of RNA Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Macromolecule Metabolic Process Signal Transduction Ubiquitin Conjugating Enzyme Binding Regulation Of Programmed Cell Death Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Epigenetic Regulation Of Gene Expression Protein Modification Process Protein Metabolic Process Apoptotic Process Intracellular Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Early Endosome Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Small Molecule Metabolic Process Programmed Cell Death Cell Death Tumor Necrosis Factor-mediated Signaling Pathway TORC1 Signaling Zinc Ion Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of RNA Metabolic Process Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cell Surface Receptor Signaling Pathway P53 Binding Protein Autoubiquitination TORC2 Complex Disassembly Metal Ion Binding
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