SIAH2 and PEG3

Number of citations of the paper that reports this interaction (PMID 10681424)
30

Data Source:
HPRD (in vivo, two hybrid)

		SIAH2	PEG3
Gene Name		siah E3 ubiquitin protein ligase 2	paternally expressed 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Early Endosome Cytosol Neuron Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle	Nucleoplasm Cytoplasm
	Molecular Function	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Conjugating Enzyme Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Nucleic Acid Binding Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Small GTPase Mediated Signal Transduction Axon Guidance Protein Ubiquitination Regulation Of Protein Ubiquitination Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	In Utero Embryonic Development Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Apoptotic Process Multicellular Organism Growth Genetic Imprinting
Pathways		Axon guidance Netrin-1 signaling	Generic Transcription Pathway
Drugs
Diseases
GWAS		Breast cancer ( 22951594)
Protein-Protein Interactions		39 interactors: AFF1 ATN1 CACYBP CCBE1 DCC DYRK2 EEF1D EGLN3 HIPK2 HIPK3 MYD88 OPRM1 PEG10 PEG3 PIAS1 PIAS2 PIAS3 PML POU2AF1 PSMD4 RBBP8 SETD2 SNCA SNCAIP SPRY2 STAT3 SYP TINF2 TP53BP2 TPX2 TRAF2 UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2L6 USP13 USP19 VAV1	5 interactors: BRCA1 SIAH1 SIAH2 TRAF2 USP7
Entrez ID		6478	5178
HPRD ID		03737	03285
Ensembl ID		ENSG00000181788	ENSG00000198300
Uniprot IDs		O43255	Q96Q96 Q9GZU2 Q9NZV7
PDB IDs			4BHX
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Apoptotic Process Regulation Of Metabolic Process Programmed Cell Death Cell Death Regulation Of Cellular Process Death Positive Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Transcription, DNA-templated Cellular Response To Stress Regulation Of Protein Metabolic Process Response To Growth Factor Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Modification-dependent Protein Catabolic Process Protein Sumoylation Response To Organic Substance Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Proteasomal Protein Catabolic Process Cellular Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Stress Negative Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Innate Immune Response Positive Regulation Of Proteolysis Regulation Of Cell Death Immune Response Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Organic Substance Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Defense Response Negative Regulation Of Biosynthetic Process Regulation Of Proteolysis Toll-like Receptor Signaling Pathway	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Protein Autoubiquitination Cellular Protein Modification Process Regulation Of Apoptotic Process Regulation Of Cell Death Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Catabolic Process Cellular Response To Tumor Necrosis Factor Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Regulation Of Proteolysis Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Tumor Necrosis Factor Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Histone H3-K9 Acetylation Cellular Macromolecule Catabolic Process Protein Polyubiquitination Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Negative Regulation Of Cell Death Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Signal Transduction Cellular Response To Indole-3-methanol Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Signaling Pathway Proteasomal Protein Catabolic Process Negative Regulation Of Centriole Replication Regulation Of Signaling Dosage Compensation By Inactivation Of X Chromosome Negative Regulation Of Glial Cell Apoptotic Process Maintenance Of DNA Methylation Protein K6-linked Ubiquitination
Tagcloud ?		adding complexity decisions determines e3 fail fate favoring feedback finger hipk2 homeodomain inactivated interferes ligase loop preferentially proline stimulates switch termination ubiquitin ubiquitination uncovers waf1 xaf1 xiap zinc znf313	alleles androgenetic chimeras embryos endure epigenotype es exceptions gametic germ h19 heritable igf2 imprinted imprints mest nnat overgrowth p57kip2 parthenogenetic paternal pefs peg1 pgcs primordial resemble strikingly unmethylated
Tagcloud (Difference) ?		adding complexity decisions determines e3 fail fate favoring feedback finger hipk2 homeodomain inactivated interferes ligase loop preferentially proline stimulates switch termination ubiquitin ubiquitination uncovers waf1 xaf1 xiap zinc znf313	alleles androgenetic chimeras embryos endure epigenotype es exceptions gametic germ h19 heritable igf2 imprinted imprints mest nnat overgrowth p57kip2 parthenogenetic paternal pefs peg1 pgcs primordial resemble strikingly unmethylated
Tagcloud (Intersection) ?