SIAH2 and TPX2

Number of citations of the paper that reports this interaction (PMID 17716627)
2

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SIAH2	TPX2
Gene Name		siah E3 ubiquitin protein ligase 2	TPX2, microtubule-associated
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Early Endosome Cytosol Neuron Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle	Spindle Pole Nucleus Nucleoplasm Cytoplasm Spindle Microtubule Microtubule Cytoskeleton Axon Hillock
	Molecular Function	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Conjugating Enzyme Binding	Protein Binding ATP Binding GTP Binding Protein Kinase Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Small GTPase Mediated Signal Transduction Axon Guidance Protein Ubiquitination Regulation Of Protein Ubiquitination Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Apoptotic Process Mitotic Nuclear Division Cell Proliferation Activation Of Protein Kinase Activity Cell Division Regulation Of Mitotic Spindle Organization
Pathways		Axon guidance Netrin-1 signaling
Drugs
Diseases
GWAS		Breast cancer ( 22951594)
Protein-Protein Interactions		39 interactors: AFF1 ATN1 CACYBP CCBE1 DCC DYRK2 EEF1D EGLN3 HIPK2 HIPK3 MYD88 OPRM1 PEG10 PEG3 PIAS1 PIAS2 PIAS3 PML POU2AF1 PSMD4 RBBP8 SETD2 SNCA SNCAIP SPRY2 STAT3 SYP TINF2 TP53BP2 TPX2 TRAF2 UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2L6 USP13 USP19 VAV1	7 interactors: AURKA CDK6 GOLGA2 HMMR NAP1L1 SIAH2 THAP11
Entrez ID		6478	22974
HPRD ID		03737	05802
Ensembl ID		ENSG00000181788	ENSG00000088325
Uniprot IDs		O43255	Q643R0 Q96RR5 Q9ULW0
PDB IDs			1OL5 3E5A 3HA6
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Apoptotic Process Regulation Of Metabolic Process Programmed Cell Death Cell Death Regulation Of Cellular Process Death Positive Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Transcription, DNA-templated Cellular Response To Stress Regulation Of Protein Metabolic Process Response To Growth Factor Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Modification-dependent Protein Catabolic Process Protein Sumoylation Response To Organic Substance Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Proteasomal Protein Catabolic Process Cellular Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Stress Negative Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Innate Immune Response Positive Regulation Of Proteolysis Regulation Of Cell Death Immune Response Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Organic Substance Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Defense Response Negative Regulation Of Biosynthetic Process Regulation Of Proteolysis Toll-like Receptor Signaling Pathway	Negative Regulation Of Protein Binding Negative Regulation Of Spindle Checkpoint Cell Dedifferentiation Cell Cycle Negative Regulation Of Binding Spindle Assembly Involved In Female Meiosis I Regulation Of Protein Binding Spindle Assembly Involved In Meiosis Mitotic Cell Cycle Spindle Stabilization Positive Regulation Of Oocyte Maturation Regulation Of Binding Mitotic Cell Cycle Phase Transition Meiotic Spindle Organization Cell Cycle Phase Transition Protein Localization To Centrosome Mitotic Centrosome Separation Negative Regulation Of Cellular Senescence Female Meiosis I Positive Regulation Of Oocyte Development Centrosome Separation Hematopoietic Stem Cell Differentiation Hyaluronan Catabolic Process Negative Regulation Of Cell Aging Dentate Gyrus Development Protein Localization To Cytoskeleton Histone-serine Phosphorylation Type B Pancreatic Cell Development
Tagcloud ?		adding complexity decisions determines e3 fail fate favoring feedback finger hipk2 homeodomain inactivated interferes ligase loop preferentially proline stimulates switch termination ubiquitin ubiquitination uncovers waf1 xaf1 xiap zinc znf313	actively autonomous clustering connected connectivity conserved degree displaying disseminated distant dormant enhances enriched etiology histologic identification inferred instead metastasis metastatic modules network networks proliferating tool transition utilized validate variation
Tagcloud (Difference) ?		adding complexity decisions determines e3 fail fate favoring feedback finger hipk2 homeodomain inactivated interferes ligase loop preferentially proline stimulates switch termination ubiquitin ubiquitination uncovers waf1 xaf1 xiap zinc znf313	actively autonomous clustering connected connectivity conserved degree displaying disseminated distant dormant enhances enriched etiology histologic identification inferred instead metastasis metastatic modules network networks proliferating tool transition utilized validate variation
Tagcloud (Intersection) ?