SIAH2 and TPX2

Number of citations of the paper that reports this interaction (PubMedID 17716627)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SIAH2	TPX2
Description		siah E3 ubiquitin protein ligase 2	TPX2 microtubule nucleation factor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Early Endosome Cytosol Neuronal Cell Body	Spindle Pole Nucleus Nucleoplasm Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton Axon Hillock Intercellular Bridge Mitotic Spindle
	Molecular Function	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity Molecular Adaptor Activity Importin-alpha Family Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Small GTPase-mediated Signal Transduction Protein Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Rhythmic Process Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Amyloid Fibril Formation Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Mitotic Cell Cycle Apoptotic Process Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Activation Of Protein Kinase Activity Cell Division Regulation Of Mitotic Spindle Organization Mitotic Spindle Assembly
Pathways		Netrin-1 signaling Ub-specific processing proteases Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation	Regulation of TP53 Activity through Phosphorylation AURKA Activation by TPX2
Drugs
Diseases
GWAS		BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 22951594 31757997)	Brain morphology (MOSTest) ( 32665545) Immature fraction of reticulocytes ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Prudent dietary pattern ( 28644415)
Interacting Genes		46 interacting genes: AFF1 AKR1C3 ATN1 CACYBP CCAR2 CCBE1 CHEK2 DCC DLST DYRK2 EEF1D EGLN3 HIPK2 HIPK3 LATS2 MYD88 NRF1 OPRM1 PEG10 PEG3 PIAS2 PIAS3 PML POU2AF1 PSMD4 RBBP8 SETD2 SNCA SNCAIP SPRY2 STAT3 SYP TINF2 TP53BP2 TPX2 TRAF2 UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2L6 UBE2N UBE2V2 USP13 USP19 VAV1	12 interacting genes: AURKA CDK6 CEBPA GOLGA2 HMMR KPNA4 NAP1L1 RNF10 SIAH2 SUMO2 THAP11 USP7
Entrez ID		6478	22974
HPRD ID		03737	05802
Ensembl ID		ENSG00000181788	ENSG00000088325
Uniprot IDs		O43255	Q643R0 Q9ULW0
PDB IDs		5H9M	1OL5 3E5A 3HA6 4C3P 5LXM 6BJC 6VPG 6VPH 6VPI 6VPJ 6VPL 6VPM 6XKA
Enriched GO Terms of Interacting Partners?		Cell Death Nucleoplasm Apoptotic Process Programmed Cell Death Nucleus Regulation Of Primary Metabolic Process Protein Modification Process Post-translational Protein Modification Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Regulation Of Macromolecule Metabolic Process Protein Polyubiquitination Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process SUMO Transferase Activity Positive Regulation Of Metabolic Process Cellular Response To Stress Protein Metabolic Process PML Body Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Macromolecule Metabolic Process Transferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress Ubiquitin Protein Ligase Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of RNA Metabolic Process Cytosol Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling DNA Damage Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Modification Process Intrinsic Apoptotic Signaling Pathway Signal Transduction By P53 Class Mediator Proteolysis Involved In Protein Catabolic Process Protein Sumoylation Negative Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Macromolecule Catabolic Process Negative Regulation Of Macromolecule Metabolic Process	Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Meiotic Spindle Assembly Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteolysis Meiotic Spindle Organization Macromolecule Metabolic Process Regulation Of Cell Development Negative Regulation Of Protein Binding Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Protein Modification Process Regulation Of Protein Binding Positive Regulation Of Catabolic Process Centrosome Cycle Positive Regulation Of Metabolic Process Cyclin D2-CDK6 Complex Animal Organ Regeneration RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Cell Development Regulation Of Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Response To Vitamin B2 C/EBP Complex Organelle Disassembly Nucleus Nucleoplasm Microtubule Organizing Center Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Notch Signaling Pathway Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Differentiation Positive Regulation Of Protein Metabolic Process CHOP-C/EBP Complex
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