SIAH2 and PSMD4

Number of citations of the paper that reports this interaction (PubMedID 22350919)
0

Data Source:
BioGRID (enzymatic study)

		SIAH2	PSMD4
Description		siah E3 ubiquitin protein ligase 2	proteasome 26S subunit ubiquitin receptor, non-ATPase 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Early Endosome Cytosol Neuronal Cell Body	Proteasome Complex Nucleus Nucleoplasm Cytosol Proteasome Regulatory Particle, Base Subcomplex Proteasome Accessory Complex
	Molecular Function	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Small GTPase-mediated Signal Transduction Protein Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Rhythmic Process Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Amyloid Fibril Formation Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Netrin-1 signaling Ub-specific processing proteases Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation	Proteasome assembly Proteasome assembly
Drugs
Diseases
GWAS		BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 22951594 31757997)	Body mass index ( 26426971) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		46 interacting genes: AFF1 AKR1C3 ATN1 CACYBP CCAR2 CCBE1 CHEK2 DCC DLST DYRK2 EEF1D EGLN3 HIPK2 HIPK3 LATS2 MYD88 NRF1 OPRM1 PEG10 PEG3 PIAS2 PIAS3 PML POU2AF1 PSMD4 RBBP8 SETD2 SNCA SNCAIP SPRY2 STAT3 SYP TINF2 TP53BP2 TPX2 TRAF2 UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2L6 UBE2N UBE2V2 USP13 USP19 VAV1	46 interacting genes: ADRM1 APP BTRC CCNA2 CFTR CUL1 EGFR FBXO25 FLOT1 GNB5 H2AC4 H2BC3 ID1 MAP3K1 MDM2 MYOD1 NEDD4 NEDD4L NEDD8 NUB1 OGT PRKN PTEN RAD23A RAD23B RASSF8 RBCK1 RBM11 SCHIP1 SIAH2 SMURF1 SREBF2 STUB1 TCF3 TCP11L1 TMEM129 TP53 TRIM63 UBB UBC UBD UBE2C UBQLN1 UBQLN2 WWP2 XPC
Entrez ID		6478	5710
HPRD ID		03737	03386
Ensembl ID		ENSG00000181788	ENSG00000159352
Uniprot IDs		O43255	P55036 Q5VWC4
PDB IDs		5H9M	1P9C 1P9D 1UEL 1YX4 1YX5 1YX6 2KDE 2KDF 5GJQ 5GJR 5L4K 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHS 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6MUN 6U19 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q
Enriched GO Terms of Interacting Partners?		Cell Death Nucleoplasm Apoptotic Process Programmed Cell Death Nucleus Regulation Of Primary Metabolic Process Protein Modification Process Post-translational Protein Modification Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Regulation Of Macromolecule Metabolic Process Protein Polyubiquitination Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process SUMO Transferase Activity Positive Regulation Of Metabolic Process Cellular Response To Stress Protein Metabolic Process PML Body Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Macromolecule Metabolic Process Transferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress Ubiquitin Protein Ligase Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of RNA Metabolic Process Cytosol Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling DNA Damage Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Modification Process Intrinsic Apoptotic Signaling Pathway Signal Transduction By P53 Class Mediator Proteolysis Involved In Protein Catabolic Process Protein Sumoylation Negative Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Macromolecule Catabolic Process Negative Regulation Of Macromolecule Metabolic Process	Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasomal Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteolysis Macromolecule Catabolic Process Post-translational Protein Modification Regulation Of Proteolysis Protein Catabolic Process Protein Modification Process Regulation Of Protein Catabolic Process Protein Metabolic Process Positive Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Ubiquitin-protein Transferase Activity Regulation Of Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Activity Protein Polyubiquitination Positive Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleus Cytosol Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Primary Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Enzyme Binding Proteasome Binding Cytoplasm Cellular Response To Stress Protein-folding Chaperone Binding Ubiquitin Binding Regulation Of Metabolic Process Negative Regulation Of Potassium Ion Export Across Plasma Membrane Protein Monoubiquitination Ubiquitin Ligase Complex Regulation Of Signal Transduction Protein Destabilization
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