PRC1 and TRIM37

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRC1	TRIM37
Gene Name		protein regulator of cytokinesis 1	tripartite motif containing 37
Image
Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Spindle Spindle Microtubule Plasma Membrane Microtubule Cytoskeleton	Cytoplasm Peroxisome Cytosol Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Microtubule Binding Kinesin Binding Protein Kinase Binding Identical Protein Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Mitotic Spindle Elongation Cytokinesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of NF-kappaB Transcription Factor Activity Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Negative Regulation Of Centriole Replication Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Aggresome Assembly
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Type 2 diabetes ( 20581827)	Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		12 interactors: CCDC85B CCNA2 CCNB1 CCNE1 CDK1 CDK2 KIF4A KRT20 PLK1 RACGAP1 TRIM37 USHBP1	59 interactors: ANKRD11 APEX2 APTX ARNT2 BYSL CCDC33 CDC20B CDK5RAP2 COPB1 CWF19L2 DDX6 DLGAP5 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RPL9 SCNM1 SSX2IP TANK TCEB3B TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZMAT2 ZNF329 ZNF417 ZNF655
Entrez ID		9055	4591
HPRD ID		17899	05463
Ensembl ID		ENSG00000198901	ENSG00000108395
Uniprot IDs		F8W9B5 O43663	A8K0V9 A8K8U4 F8WEE6 O94972
PDB IDs		3NRX 3NRY 4L3I 4L6Y	3LRQ
Enriched GO Terms of Interacting Partners?		Cell Division Mitotic Nuclear Division Mitotic Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Transition Of Mitotic Cell Cycle Cell Cycle Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Cell Cycle G2 DNA Damage Checkpoint Mitotic Nuclear Envelope Disassembly DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Organelle Organization Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Histone Phosphorylation Nuclear Envelope Disassembly Microtubule Cytoskeleton Organization Negative Regulation Of Cell Cycle Mitotic Cytokinesis Regulation Of Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Cell Cycle Checkpoint Mitotic Spindle Midzone Assembly Nuclear Envelope Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cytoskeleton Organization Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic Spindle Elongation Positive Regulation Of Ligase Activity Regulation Of Chromosome Segregation Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Response To Wounding Spindle Midzone Assembly Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Mitotic DNA Damage Checkpoint Regulation Of Protein Kinase Activity Centrosome Organization Mitotic DNA Integrity Checkpoint Microtubule-based Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity	Protein Polyubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway Protein K48-linked Ubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Protein Ubiquitination Protein Modification By Small Protein Conjugation Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Cellular Macromolecule Catabolic Process Regulation Of Innate Immune Response Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K63-linked Ubiquitination Cellular Response To Stress Catabolic Process Polynucleotide 3' Dephosphorylation Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Catabolic Process Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of DNA-templated Transcription In Response To Stress Programmed Cell Death I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To DNA Damage Stimulus Regulation Of Cell Cycle Phase Transition Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Cell Death Death Activation Of NF-kappaB-inducing Kinase Activity Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Cellular Protein Catabolic Process DNA Repair Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Stress-activated MAPK Cascade NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Regulation Of Metabolic Process
Tagcloud ?		activates autism auts2 candidate canonical chip ck2 cns comprise conditional developmental disrupted immunoprecipitation leads linking modulators naturally nervous neurodevelopment neuronal neutralizes occurring polycomb repression repressive seq subverting surprisingly variations
Tagcloud (Difference) ?		activates autism auts2 candidate canonical chip ck2 cns comprise conditional developmental disrupted immunoprecipitation leads linking modulators naturally nervous neurodevelopment neuronal neutralizes occurring polycomb repression repressive seq subverting surprisingly variations
Tagcloud (Intersection) ?