PRC1 and KIF4A

Number of citations of the paper that reports this interaction (PMID 15297875)
65

Data Source:
BioGRID (affinity chromatography technology, pull down, two hybrid)

		PRC1	KIF4A
Gene Name		protein regulator of cytokinesis 1	kinesin family member 4A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Spindle Spindle Microtubule Plasma Membrane Microtubule Cytoskeleton	Nucleoplasm Chromosome Cytoplasm Cytosol Kinesin Complex Spindle Microtubule Membrane Nuclear Matrix Midbody
	Molecular Function	Protein Binding Microtubule Binding Kinesin Binding Protein Kinase Binding Identical Protein Binding	DNA Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity
	Biological Process	Mitotic Spindle Elongation Cytokinesis	Mitotic Cytokinesis Organelle Organization Microtubule-based Movement Axon Guidance Blood Coagulation Anterograde Axon Cargo Transport Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Mitotic Spindle Midzone Assembly
Pathways			Axon guidance MHC class II antigen presentation Kinesins L1CAM interactions Recycling pathway of L1 Factors involved in megakaryocyte development and platelet production Adaptive Immune System
Drugs
Diseases
GWAS		Type 2 diabetes ( 20581827)
Protein-Protein Interactions		12 interactors: CCDC85B CCNA2 CCNB1 CCNE1 CDK1 CDK2 KIF4A KRT20 PLK1 RACGAP1 TRIM37 USHBP1	5 interactors: APP DNMT3B HMG20B PRC1 TTF2
Entrez ID		9055	24137
HPRD ID		17899	06606
Ensembl ID		ENSG00000198901	ENSG00000090889
Uniprot IDs		F8W9B5 O43663	O95239 Q59HG1
PDB IDs		3NRX 3NRY 4L3I 4L6Y
Enriched GO Terms of Interacting Partners?		Cell Division Mitotic Nuclear Division Mitotic Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Transition Of Mitotic Cell Cycle Cell Cycle Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Cell Cycle G2 DNA Damage Checkpoint Mitotic Nuclear Envelope Disassembly DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Organelle Organization Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Histone Phosphorylation Nuclear Envelope Disassembly Microtubule Cytoskeleton Organization Negative Regulation Of Cell Cycle Mitotic Cytokinesis Regulation Of Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Cell Cycle Checkpoint Mitotic Spindle Midzone Assembly Nuclear Envelope Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cytoskeleton Organization Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic Spindle Elongation Positive Regulation Of Ligase Activity Regulation Of Chromosome Segregation Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Response To Wounding Spindle Midzone Assembly Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Mitotic DNA Damage Checkpoint Regulation Of Protein Kinase Activity Centrosome Organization Mitotic DNA Integrity Checkpoint Microtubule-based Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity	Regulation Of Neuron Differentiation Regulation Of Neurogenesis Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Synaptic Growth At Neuromuscular Junction Pharynx Development Regulation Of Cell Development Negative Regulation Of Protein Metabolic Process Collateral Sprouting In Absence Of Injury S-adenosylmethioninamine Metabolic Process DNA Methylation On Cytosine Within A CG Sequence Collateral Sprouting Negative Regulation Of Protein Sumoylation Axon Midline Choice Point Recognition Cellular Modified Amino Acid Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis C-5 Methylation Of Cytosine S-adenosylhomocysteine Metabolic Process Axon Choice Point Recognition Soft Palate Development Mitotic Spindle Elongation Methylation-dependent Chromatin Silencing Positive Regulation Of Neuron Differentiation Neuron Remodeling Gene Expression Hard Palate Development Positive Regulation Of Gene Expression Generation Of Neurons Negative Regulation Of Histone H3-K9 Methylation DNA Methylation On Cytosine Regulation Of Cell Differentiation Positive Regulation Of Neurogenesis Blood Coagulation MRNA Processing Neurogenesis Hemostasis Positive Regulation Of Histone H3-K4 Methylation Response To Radiation Regulation Of Protein Sumoylation Cellular Copper Ion Homeostasis Thyroid Hormone Generation Protein Complex Localization Negative Regulation Of Histone Methylation Regulation Of Transcription From RNA Polymerase II Promoter System Development Positive Regulation Of Cell Development Regulation Of Transcription, DNA-templated Copper Ion Homeostasis Suckling Behavior Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		activates autism auts2 candidate canonical chip ck2 cns comprise conditional developmental disrupted immunoprecipitation leads linking modulators naturally nervous neurodevelopment neuronal neutralizes occurring polycomb repression repressive seq subverting surprisingly variations	aba achieved adp aminobenzamide apoptosis blot cleaved cytometry doxorubicin elevated fragments inhibiting kinesin manners mb mcf mda par parp poly polymerase profound quantitated reduce ribose slightly super upregulation
Tagcloud (Difference) ?		activates autism auts2 candidate canonical chip ck2 cns comprise conditional developmental disrupted immunoprecipitation leads linking modulators naturally nervous neurodevelopment neuronal neutralizes occurring polycomb repression repressive seq subverting surprisingly variations	aba achieved adp aminobenzamide apoptosis blot cleaved cytometry doxorubicin elevated fragments inhibiting kinesin manners mb mcf mda par parp poly polymerase profound quantitated reduce ribose slightly super upregulation
Tagcloud (Intersection) ?