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PRC1 and CCNB1
Number of citations of the paper that reports this interaction (PubMedID
9885575
)
0
Data Source:
BioGRID
(enzymatic study)
PRC1
CCNB1
Description
protein regulator of cytokinesis 1
cyclin B1
Image
GO Annotations
Cellular Component
Spindle Pole
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Spindle
Cytosol
Cytoskeleton
Microtubule
Spindle Microtubule
Plasma Membrane
Microtubule Cytoskeleton
Midbody
Intercellular Bridge
Contractile Ring
Mitotic Spindle Midzone
Spindle Pole
Outer Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrial Matrix
Centrosome
Microtubule Organizing Center
Cytosol
Cytoskeleton
Membrane
Cyclin B1-CDK1 Complex
Molecular Function
Protein Binding
Microtubule Binding
Kinesin Binding
Protein Kinase Binding
Identical Protein Binding
Patched Binding
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Protein Kinase Binding
Ubiquitin-like Protein Ligase Binding
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
Biological Process
Mitotic Spindle Elongation
Microtubule Cytoskeleton Organization
Positive Regulation Of Cell Population Proliferation
Regulation Of Cytokinesis
Mitotic Spindle Midzone Assembly
Cell Division
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Oocyte Maturation
In Utero Embryonic Development
Mitotic Spindle Organization
Mitotic Metaphase Chromosome Alignment
Spermatogenesis
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Response To Toxic Substance
Negative Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of MRNA 3'-end Processing
Tissue Regeneration
Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle
Positive Regulation Of Mitotic Cell Cycle
Response To DDT
Positive Regulation Of Fibroblast Proliferation
Digestive Tract Development
Cell Division
Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Ventricular Cardiac Muscle Cell Development
Positive Regulation Of Cardiac Muscle Cell Proliferation
Regulation Of Chromosome Condensation
Protein-containing Complex Assembly
Cellular Response To Iron(III) Ion
Cellular Response To Fatty Acid
Cellular Response To Hypoxia
Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Pathways
RHO GTPases activate CIT
E2F-enabled inhibition of pre-replication complex formation
Polo-like kinase mediated events
Golgi Cisternae Pericentriolar Stack Reorganization
APC/C:Cdc20 mediated degradation of Cyclin B
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
MASTL Facilitates Mitotic Progression
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Initiation of Nuclear Envelope (NE) Reformation
Nuclear Pore Complex (NPC) Disassembly
Depolymerization of the Nuclear Lamina
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Mitotic Prophase
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
The role of GTSE1 in G2/M progression after G2 checkpoint
Transcriptional regulation by RUNX2
Nuclear events stimulated by ALK signaling in cancer
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs
Diseases
GWAS
Breast cancer (
25038754
29059683
)
Mean platelet volume (
27863252
32888494
)
Multisite chronic pain (
31194737
33830993
)
Red cell distribution width (
32888494
)
Type 2 diabetes (
20581827
22885922
24509480
26818947
28869590
30054458
30297969
30718926
32499647
)
Interacting Genes
43 interacting genes:
AKAP9
BICD2
CASK
CCDC85B
CCNA2
CCNB1
CCNE1
CDK1
CDK2
CEBPA
CINP
EMG1
EXOSC7
EXOSC8
FXR2
KIF3B
KIF4A
KLC2
KLC4
KRT20
LARP4
MAT2A
NDEL1
NUDT16
OGT
PBK
PCM1
PKIA
PLK1
PPIE
RACGAP1
RBM10
RBM17
RBM22
RPA2
SF3B2
SLAIN1
SUMO2
TFIP11
THOC1
TRIM37
USHBP1
YWHAE
64 interacting genes:
ANAPC11
ARID4A
BRCA1
BTG2
CCNB1IP1
CCNF
CDC25A
CDC25C
CDC34
CDC6
CDH1
CDK1
CDKN1A
CDKN1B
CDT1
CEBPA
CSNK2B
CUX1
EP300
FLNA
FZR1
GADD45A
GADD45B
GADD45G
H1-1
H1-5
HERC5
ITPR1
KAT5
KPNB1
MAP4
MEF2C
MOK
NACC1
OGT
OTUD7B
PBK
PCNA
PIN1
PKMYT1
PLK1
PRC1
PRKDC
PTCH1
PTMA
RALBP1
RB1
RUNX2
TGFBR2
TP53BP1
TP73
TSC1
TSPYL2
TULP3
UBE2D2
UBE2N
UBE3C
UBE3D
UCHL3
USP39
WEE1
XIAP
XRCC6
ZFAND5
Entrez ID
9055
891
HPRD ID
17899
00454
Ensembl ID
ENSG00000198901
ENSG00000134057
Uniprot IDs
O43663
P14635
PDB IDs
3NRX
3NRY
4L3I
4L6Y
5KMG
7VBG
2B9R
2JGZ
4Y72
4YC3
5HQ0
5LQF
6GU2
6GU3
6GU4
7NJ0
8TAR
8TAU
9FH9
Enriched GO Terms of Interacting Partners
?
Microtubule-based Process
Nucleic Acid Metabolic Process
Organelle Organization
Microtubule Cytoskeleton Organization
G2/M Transition Of Mitotic Cell Cycle
Cytoskeleton
Cell Cycle G2/M Phase Transition
Cytoskeleton Organization
Nucleobase-containing Compound Metabolic Process
Microtubule Cytoskeleton Organization Involved In Mitosis
Regulation Of Cell Cycle
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cell Cycle Process
Mitotic Cell Cycle Phase Transition
Cytoplasm
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Intracellular Protein Transport
MRNA Metabolic Process
Cell Cycle G1/S Phase Transition
Nucleoplasm
Nucleus
Cell Cycle Phase Transition
Centrosome Separation
Centrosome
Spindle Microtubule
Microtubule Organizing Center
RNA Metabolic Process
Regulation Of Intracellular Transport
Cyclin-dependent Protein Kinase Holoenzyme Complex
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Kinesin Complex
Cyclin A2-CDK1 Complex
Cyclin B1-CDK1 Complex
Regulation Of G2/M Transition Of Mitotic Cell Cycle
MRNA Splicing, Via Spliceosome
Regulation Of Proteasomal Protein Catabolic Process
RNA Binding
Regulation Of Cell Cycle G2/M Phase Transition
Regulation Of Nucleocytoplasmic Transport
RNA Splicing, Via Transesterification Reactions
Cell Division
Cyclin A2-CDK2 Complex
Cyclin E1-CDK2 Complex
Cyclin-dependent Protein Kinase Activity
U5 SnRNA 3'-end Processing
U1 SnRNA 3'-end Processing
Regulation Of Mitotic Cell Cycle Phase Transition
Protein Localization To Organelle
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Mitotic DNA Damage Checkpoint Signaling
Regulation Of Cell Cycle
Nucleoplasm
Nucleus
Regulation Of Protein Modification Process
Intracellular Signal Transduction
Negative Regulation Of Cell Cycle
Regulation Of Primary Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Cell Cycle Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Regulation Of DNA Metabolic Process
Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Negative Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of DNA Replication
Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle G2/M Phase Transition
Negative Regulation Of Cell Cycle Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Protein Phosphorylation
Regulation Of Catalytic Activity
Positive Regulation Of DNA Replication
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Modification Process
Signal Transduction In Response To DNA Damage
Regulation Of Phosphorus Metabolic Process
Negative Regulation Of Cell Cycle G2/M Phase Transition
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Phosphorylation
Positive Regulation Of DNA Metabolic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Cellular Response To Stress
Cell Division
DNA Metabolic Process
Regulation Of Protein Kinase Activity
Negative Regulation Of DNA Metabolic Process
Cyclin Binding
Regulation Of Kinase Activity
DNA Damage Response
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
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