PRC1 and NUDT16

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		PRC1	NUDT16
Description		protein regulator of cytokinesis 1	nudix hydrolase 16
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Plasma Membrane Microtubule Cytoskeleton Midbody Intercellular Bridge Contractile Ring Mitotic Spindle Midzone	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Protein Binding Microtubule Binding Kinesin Binding Protein Kinase Binding Identical Protein Binding	Nucleotide Binding Magnesium Ion Binding RNA Binding MRNA Binding Metalloexopeptidase Activity Hydrolase Activity Nucleoside Diphosphate Phosphatase Activity Manganese Ion Binding SnoRNA Binding Chloride Ion Binding DITP Diphosphatase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Cobalt Ion Binding DIDP Phosphatase Activity RNA NAD-cap (NMN-forming) Hydrolase Activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity IDP Phosphatase Activity Phosphodiesterase Decapping Endonuclease Activity
	Biological Process	Mitotic Spindle Elongation Microtubule Cytoskeleton Organization Positive Regulation Of Cell Population Proliferation Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly Cell Division	MRNA Catabolic Process Nucleotide Metabolic Process Sno(s)RNA Catabolic Process DITP Catabolic Process Positive Regulation Of Cell Cycle Process NAD-cap Decapping Negative Regulation Of RRNA Processing
Pathways		RHO GTPases activate CIT	Phosphate bond hydrolysis by NUDT proteins
Drugs
Diseases
GWAS		Breast cancer ( 25038754 29059683) Mean platelet volume ( 27863252 32888494) Multisite chronic pain ( 31194737 33830993) Red cell distribution width ( 32888494) Type 2 diabetes ( 20581827 22885922 24509480 26818947 28869590 30054458 30297969 30718926 32499647)
Interacting Genes		43 interacting genes: AKAP9 BICD2 CASK CCDC85B CCNA2 CCNB1 CCNE1 CDK1 CDK2 CEBPA CINP EMG1 EXOSC7 EXOSC8 FXR2 KIF3B KIF4A KLC2 KLC4 KRT20 LARP4 MAT2A NDEL1 NUDT16 OGT PBK PCM1 PKIA PLK1 PPIE RACGAP1 RBM10 RBM17 RBM22 RPA2 SF3B2 SLAIN1 SUMO2 TFIP11 THOC1 TRIM37 USHBP1 YWHAE	3 interacting genes: PARP1 PRC1 TP53BP1
Entrez ID		9055	131870
HPRD ID		17899	08097
Ensembl ID		ENSG00000198901	ENSG00000198585
Uniprot IDs		O43663	Q96DE0
PDB IDs		3NRX 3NRY 4L3I 4L6Y 5KMG 7VBG	2XSQ 3COU 3MGM 5VY2 5W6X 5W6Z 5WJI 6B09 6CO2 6X7U 6X7V
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Nucleic Acid Metabolic Process Organelle Organization Microtubule Cytoskeleton Organization G2/M Transition Of Mitotic Cell Cycle Cytoskeleton Cell Cycle G2/M Phase Transition Cytoskeleton Organization Nucleobase-containing Compound Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Mitotic Cell Cycle Phase Transition Cytoplasm G1/S Transition Of Mitotic Cell Cycle Regulation Of Intracellular Protein Transport MRNA Metabolic Process Cell Cycle G1/S Phase Transition Nucleoplasm Nucleus Cell Cycle Phase Transition Centrosome Separation Centrosome Spindle Microtubule Microtubule Organizing Center RNA Metabolic Process Regulation Of Intracellular Transport Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Kinesin Complex Cyclin A2-CDK1 Complex Cyclin B1-CDK1 Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle MRNA Splicing, Via Spliceosome Regulation Of Proteasomal Protein Catabolic Process RNA Binding Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Nucleocytoplasmic Transport RNA Splicing, Via Transesterification Reactions Cell Division Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cyclin-dependent Protein Kinase Activity U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Regulation Of Mitotic Cell Cycle Phase Transition Protein Localization To Organelle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic DNA Damage Checkpoint Signaling	Protein Localization To Site Of Double-strand Break Positive Regulation Of DNA Recombination Protein Localization To Chromosome NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity Chromosome NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Damaged DNA Binding Site Of Double-strand Break Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of DNA Metabolic Process NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Response To Ionizing Radiation Regulation Of DNA Recombination NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Regulation Of Double-strand Break Repair Positive Regulation Of Myofibroblast Differentiation Cellular Response To Radiation NAD+-protein-serine ADP-ribosyltransferase Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Chromosome, Telomeric Region RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Mitotic Spindle Elongation DNA ADP-ribosylation Double-strand Break Repair Negative Regulation Of ATP Biosynthetic Process NAD DNA ADP-ribosyltransferase Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Repair Regulation Of Base-excision Repair ATP Generation From Poly-ADP-D-ribose Histone H4K20me Methyltransferase Activity Positive Regulation Of DNA Metabolic Process Transcription Pausing By RNA Polymerase II Replication Fork Reversal Spindle Elongation Histone H4K20me2 Reader Activity Positive Regulation Of Necroptotic Process Mitochondrial DNA Repair Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Contractile Ring Nuclear Body Negative Regulation Of Adipose Tissue Development Ubiquitin-modified Histone Reader Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Myofibroblast Differentiation Positive Regulation Of Mitochondrial Depolarization Regulation Of Apoptotic Signaling Pathway Mitotic Spindle Midzone Assembly
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