PRC1 and KIF3B

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		PRC1	KIF3B
Description		protein regulator of cytokinesis 1	kinesin family member 3B
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Plasma Membrane Microtubule Cytoskeleton Midbody Intercellular Bridge Contractile Ring Mitotic Spindle Midzone	Cytoplasm Centrosome Cytosol Cytoskeleton Kinesin Complex Plus-end Kinesin Complex Microtubule Spindle Microtubule Cilium Microtubule Cytoskeleton Membrane Kinesin II Complex Axon Dendrite Midbody Dendrite Cytoplasm Cell Projection Dendritic Spine Synapse Extracellular Exosome Ciliary Tip Postsynapse Glutamatergic Synapse Axon Cytoplasm
	Molecular Function	Protein Binding Microtubule Binding Kinesin Binding Protein Kinase Binding Identical Protein Binding	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity Small GTPase Binding Intraciliary Transport Particle B Binding
	Biological Process	Mitotic Spindle Elongation Microtubule Cytoskeleton Organization Positive Regulation Of Cell Population Proliferation Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly Cell Division	Microtubule-based Movement Mitotic Spindle Organization Mitotic Centrosome Separation Determination Of Left/right Symmetry Axo-dendritic Transport Anterograde Axonal Transport Vesicle-mediated Transport Protein-containing Complex Localization Positive Regulation Of Cytokinesis Opsin Transport Intraciliary Transport Cilium Assembly Plus-end-directed Vesicle Transport Along Microtubule Mitotic Spindle Assembly Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex
Pathways		RHO GTPases activate CIT	Translocation of SLC2A4 (GLUT4) to the plasma membrane MHC class II antigen presentation Intraflagellar transport COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins
Drugs
Diseases
GWAS		Breast cancer ( 25038754 29059683) Mean platelet volume ( 27863252 32888494) Multisite chronic pain ( 31194737 33830993) Red cell distribution width ( 32888494) Type 2 diabetes ( 20581827 22885922 24509480 26818947 28869590 30054458 30297969 30718926 32499647)	Age at first sexual intercourse ( 27089180 34211149) Chronic obstructive pulmonary disease ( 28166215) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252)
Interacting Genes		43 interacting genes: AKAP9 BICD2 CASK CCDC85B CCNA2 CCNB1 CCNE1 CDK1 CDK2 CEBPA CINP EMG1 EXOSC7 EXOSC8 FXR2 KIF3B KIF4A KLC2 KLC4 KRT20 LARP4 MAT2A NDEL1 NUDT16 OGT PBK PCM1 PKIA PLK1 PPIE RACGAP1 RBM10 RBM17 RBM22 RPA2 SF3B2 SLAIN1 SUMO2 TFIP11 THOC1 TRIM37 USHBP1 YWHAE	12 interacting genes: APP IFT20 KIF3A KIFAP3 LMO2 LMO4 MAP3K10 MAP3K11 NEDD4L PRC1 RAB4A SASH1
Entrez ID		9055	9371
HPRD ID		17899	04781
Ensembl ID		ENSG00000198901	ENSG00000101350
Uniprot IDs		O43663	O15066
PDB IDs		3NRX 3NRY 4L3I 4L6Y 5KMG 7VBG	3B6U
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Nucleic Acid Metabolic Process Organelle Organization Microtubule Cytoskeleton Organization G2/M Transition Of Mitotic Cell Cycle Cytoskeleton Cell Cycle G2/M Phase Transition Cytoskeleton Organization Nucleobase-containing Compound Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Cell Cycle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Mitotic Cell Cycle Phase Transition Cytoplasm G1/S Transition Of Mitotic Cell Cycle Regulation Of Intracellular Protein Transport MRNA Metabolic Process Cell Cycle G1/S Phase Transition Nucleoplasm Nucleus Cell Cycle Phase Transition Centrosome Separation Centrosome Spindle Microtubule Microtubule Organizing Center RNA Metabolic Process Regulation Of Intracellular Transport Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Kinesin Complex Cyclin A2-CDK1 Complex Cyclin B1-CDK1 Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle MRNA Splicing, Via Spliceosome Regulation Of Proteasomal Protein Catabolic Process RNA Binding Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Nucleocytoplasmic Transport RNA Splicing, Via Transesterification Reactions Cell Division Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Cyclin-dependent Protein Kinase Activity U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Regulation Of Mitotic Cell Cycle Phase Transition Protein Localization To Organelle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic DNA Damage Checkpoint Signaling	Positive Regulation Of JUN Kinase Activity Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Kinase Activity Positive Regulation Of MAP Kinase Activity Kinesin II Complex Spindle Microtubule Ciliary Tip Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Microtubule-based Process Positive Regulation Of Protein Serine/threonine Kinase Activity Plus-end-directed Vesicle Transport Along Microtubule Plus-end-directed Organelle Transport Along Microtubule Plasma Membrane Bounded Cell Projection Organization Microtubule-based Transport Regulation Of MAP Kinase Activity JUN Kinase Kinase Kinase Activity Axo-dendritic Transport Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of JNK Cascade Cell Projection Organization Positive Regulation Of Catalytic Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Microtubule-based Movement MAP Kinase Kinase Kinase Activity Regulation Of JNK Cascade Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation BHLH Transcription Factor Binding Positive Regulation Of MAPK Cascade Neuron Projection Development Kinesin Binding Photoreceptor Connecting Cilium Regulation Of Catalytic Activity Vesicle Transport Along Microtubule Kinesin Complex Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Receptor Localization To Synapse Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning Microtubule Cytoskeleton
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