GFRA1 and NRTN

Number of citations of the paper that reports this interaction (PMID 9407096)
12

Data Source:
BioGRID (pull down, pull down)
HPRD (in vivo, in vitro)

		GFRA1	NRTN
Gene Name		GDNF family receptor alpha 1	neurturin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome	Extracellular Region Axon
	Molecular Function	Receptor Binding Glial Cell-derived Neurotrophic Factor Receptor Activity	Receptor Binding Growth Factor Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Axon Guidance Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway	MAPK Cascade Neural Crest Cell Migration Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Nerve Development Neuron Projection Development
Pathways		NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth	NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS			N-glycan levels ( 21203500)
Protein-Protein Interactions		6 interactors: GDNF NCAM1 NRTN RET SOCS3 TRADD	3 interactors: GFRA1 GFRA2 RET
Entrez ID		2674	4902
HPRD ID		03291	03604
Ensembl ID		ENSG00000151892	ENSG00000171119
Uniprot IDs		B7Z856 P56159	Q99748
PDB IDs
Enriched GO Terms of Interacting Partners?		Neural Crest Cell Migration Neural Crest Cell Development Neural Crest Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mesenchymal Cell Development Mesenchymal Cell Differentiation Enteric Nervous System Development Ameboidal-type Cell Migration Regulation Of Extrinsic Apoptotic Signaling Pathway Mesenchyme Development Stem Cell Development Positive Regulation Of Kidney Development Neuron Development Stem Cell Differentiation Autonomic Nervous System Development Anatomical Structure Morphogenesis Neuron Differentiation Axon Guidance Locomotion Signal Transduction Cytokine-mediated Signaling Pathway Morphogenesis Of An Epithelium Signaling Regulation Of Apoptotic Process Axonogenesis Cell Communication Movement Of Cell Or Subcellular Component Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Surface Receptor Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Nerve Development Regulation Of Cell Death Generation Of Neurons Axon Development Cellular Response To Cytokine Stimulus Cell Morphogenesis Involved In Neuron Differentiation Zymogen Activation Metanephros Development Chemotaxis Neurogenesis Cell Differentiation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Ureteric Bud Development Neuron Projection Morphogenesis Mesonephric Tubule Development Mesonephric Epithelium Development Tissue Development Embryonic Morphogenesis Tissue Morphogenesis Interferon-gamma-mediated Signaling Pathway	Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Posterior Midgut Development Positive Regulation Of Neuron Maturation Lymphocyte Migration Into Lymphoid Organs Cellular Response To Organic Substance Peyer's Patch Morphogenesis Positive Regulation Of Metanephric Glomerulus Development Ureter Maturation Regulation Of Neuron Maturation Nervous System Development Cytokine-mediated Signaling Pathway Positive Regulation Of Glomerulus Development Negative Regulation Of Protein Autophosphorylation Response To Organic Substance Enteric Nervous System Development Cellular Response To Cytokine Stimulus Neuron Cell-cell Adhesion Positive Regulation Of Cell Size Ureter Development Positive Regulation Of Cell Adhesion Mediated By Integrin Peyer's Patch Development Cell Surface Receptor Signaling Pathway Midgut Development Response To Cytokine Regulation Of Protein Autophosphorylation Neuron Maturation Lymphocyte Migration Membrane Protein Proteolysis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Innervation Positive Regulation Of Kidney Development Neuron Development Response To Pain Regulation Of Cell Adhesion Mediated By Integrin Autonomic Nervous System Development System Development Neural Crest Cell Migration Neuron Differentiation Locomotion Multicellular Organismal Development Neural Crest Cell Development Cellular Response To Retinoic Acid Anatomical Structure Development Neural Crest Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Signal Transduction Multicellular Organismal Response To Stress
Tagcloud ?		amplifies angptl4 antigens autoantibodies autoantibody calibrated capabilities classify conditional conformational deciles dkk1 elicit encode epitopes gal1 grn hosmer humoral inversely lemeshow likelihood lrrc15 minimally muc1 race reflects select sizes	bain biol dev division es excitotoxic gdnf gfralpha1 gfralpha2 grown immunocytochemistry injured ligands likelihood lineage manipulable modestly neurons neurotrophin neurotrophins neurturin nmda nt oligodendrocytes plating pluripotential pretreatment ret vulnerability
Tagcloud (Difference) ?		amplifies angptl4 antigens autoantibodies autoantibody calibrated capabilities classify conditional conformational deciles dkk1 elicit encode epitopes gal1 grn hosmer humoral inversely lemeshow lrrc15 minimally muc1 race reflects select sizes	bain biol dev division es excitotoxic gdnf gfralpha1 gfralpha2 grown immunocytochemistry injured ligands lineage manipulable modestly neurons neurotrophin neurotrophins neurturin nmda nt oligodendrocytes plating pluripotential pretreatment ret vulnerability
Tagcloud (Intersection) ?		likelihood