GFRA1 and NRTN

Number of citations of the paper that reports this interaction (PubMedID 9407096)
0

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro, in vivo)

		GFRA1	NRTN
Description		GDNF family receptor alpha 1	neurturin
Image
GO Annotations	Cellular Component	Extracellular Space Endosome Multivesicular Body Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Membrane Extrinsic Component Of Membrane Axon Neuronal Cell Body Receptor Complex Extracellular Exosome Side Of Membrane Plasma Membrane Protein Complex	Extracellular Region Extracellular Space
	Molecular Function	Neurotrophin Receptor Activity Signaling Receptor Binding Integrin Binding Protein Binding Glial Cell-derived Neurotrophic Factor Receptor Activity Signaling Receptor Activity	Signaling Receptor Binding Growth Factor Activity Glial Cell-derived Neurotrophic Factor Receptor Binding Receptor Tyrosine Kinase Binding Heparan Sulfate Binding
	Biological Process	Kidney Development Cell Surface Receptor Signaling Pathway Nervous System Development Male Gonad Development Cell Migration Neuron Differentiation Neuron Projection Development Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway	MAPK Cascade Neural Crest Cell Migration Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Nerve Development Neuron Projection Development Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT
Pathways		NCAM1 interactions RAF/MAP kinase cascade RET signaling Formation of the ureteric bud	NCAM1 interactions RAF/MAP kinase cascade RET signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Delirium ( 29631748) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Malaria ( 31844061) Migraine without aura ( 28952330) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603)	Advanced age-related macular degeneration ( 26691988) Chronotype ( 30696823) N-glycan levels ( 21203500 21908519 31163085)
Interacting Genes		5 interacting genes: GDNF NCAM1 NRTN RET SOCS3	3 interacting genes: GFRA1 GFRA2 RET
Entrez ID		2674	4902
HPRD ID		03291	03604
Ensembl ID		ENSG00000151892	ENSG00000171119
Uniprot IDs		B7Z856 P56159	Q99748
PDB IDs		6Q2N	5MR4 5MR5 5MR9 5NMZ 6GL7 6Q2O 6Q2R
Enriched GO Terms of Interacting Partners?		Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Binding Neural Crest Cell Migration Regulation Of Semaphorin-plexin Signaling Pathway Mesenchymal Cell Migration Neuron Projection Development Ameboidal-type Cell Migration Enteric Nervous System Development Commissural Neuron Axon Guidance Embryonic Epithelial Tube Formation Neuron Projection Guidance Axon Guidance Plasma Membrane Bounded Cell Projection Organization Epithelial Tube Formation Metanephros Development Regulation Of Kidney Development Ureteric Bud Development Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mesonephric Epithelium Development Mesonephric Tubule Development Cell Projection Organization Receptor Tyrosine Kinase Binding Tissue Morphogenesis Kidney Epithelium Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Nervous System Development Enzyme-linked Receptor Protein Signaling Pathway Chemoattractant Activity Involved In Axon Guidance Postganglionic Parasympathetic Fiber Development Tube Formation Posterior Midgut Development Morphogenesis Of A Branching Structure Regulation Of Extrinsic Apoptotic Signaling Pathway Growth Factor Activity Morphogenesis Of A Branching Epithelium Cell Surface Receptor Signaling Pathway Chemoattraction Of Axon Peyer's Patch Morphogenesis Positive Regulation Of Metanephric Glomerulus Development Kidney Development Positive Regulation Of Ureteric Bud Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Ureter Maturation Autonomic Nervous System Development Ureteric Bud Formation Cell Migration Dorsal Spinal Cord Development GDF15-GFRAL Signaling Pathway Positive Regulation Of Glomerulus Development	Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Activity Receptor Complex Extrinsic Component Of Membrane Plasma Membrane Protein Complex Signaling Receptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Enzyme-linked Receptor Protein Signaling Pathway Side Of Membrane Posterior Midgut Development Kidney Development Peyer's Patch Morphogenesis Positive Regulation Of Metanephric Glomerulus Development System Development Neurotrophin Receptor Activity Ureter Maturation GDF15-GFRAL Signaling Pathway Positive Regulation Of Glomerulus Development Heparan Sulfate Binding Lymphocyte Migration Into Lymphoid Organs External Side Of Plasma Membrane Positive Regulation Of Kidney Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Differentiation Positive Regulation Of Cell Size Enteric Nervous System Development Axon Neuron Cell-cell Adhesion Response To Pain Neuron Projection Development Positive Regulation Of Cell Adhesion Mediated By Integrin Cell Surface Receptor Signaling Pathway Embryonic Epithelial Tube Formation Neurotrophin Signaling Pathway Neuron Maturation Epithelial Tube Formation Membrane Protein Proteolysis Regulation Of Kidney Development Metanephros Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?