PLOD3 and SORBS3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		PLOD3	SORBS3
Name		procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	sorbin and SH3 domain containing 3
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Membrane Extracellular Matrix Extracellular Exosome	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell-substrate Junction Anchoring Junction
	Molecular Function	Catalytic Activity Iron Ion Binding Protein Binding Procollagen-lysine 5-dioxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Transferase Activity Glycosyltransferase Activity L-ascorbic Acid Binding Procollagen Glucosyltransferase Activity Small Molecule Binding Metal Ion Binding Procollagen Galactosyltransferase Activity Dioxygenase Activity	Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding
	Biological Process	In Utero Embryonic Development Endothelial Cell Morphogenesis Protein O-linked Glycosylation Intracellular Protein Localization Peptidyl-lysine Hydroxylation Neural Tube Development Collagen Fibril Organization Collagen Metabolic Process Vasodilation Hydroxylysine Biosynthetic Process Epidermis Morphogenesis Lung Morphogenesis Basement Membrane Assembly	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Cytoskeleton Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly
Pathways		Collagen biosynthesis and modifying enzymes	Smooth Muscle Contraction
Drugs		Ascorbic acid	None
GWAS		Blood protein levels ( 30072576 ) Cerebral amyloid angiopathy in Alzheimer’s disease ( 34020725 )	Diastolic blood pressure ( 30224653 ) HIV-1 viral setpoint ( 20205591 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Parkinson's disease ( 28892059 )
Novel Interactors		None recorded	1 novel interactors: PPP3CC
Interacting Genes		20 interacting genes: CCDC85B COIL COL17A1 CRIP3 DPPA2 EFHC2 EHMT2 FAM153A IP6K2 KCTD9 KHNYN L3MBTL3 LINC00839 NAB2 RAB3IP RALY RHOU RHOXF2 SORBS3 ZNF620	137 interacting genes: ABI2 ABL1 ADAM15 ADAMTSL4 ADAT3 AIRIM AKIRIN2 AKT2 ANKS1A ARNT2 ATOSB CATSPER1 CBFA2T2 CBLB CCDC102B CCDC120 CCDC187 CCDC57 CCDC6 CCHCR1 CCNH CCNL1 CDC23 CDKN2C CFAP206 CFTR CHERP COG4 CPEB2 CPNE1 CPNE2 CPNE8 CPSF7 CRACR2A DDX17 DDX6 DIP2A DLG5 DMRTB1 DRC4 DVL2 DVL3 EFHC1 EFS EIF3H ENKD1 FAM53C FASLG FBXL19 FLOT1 FNDC11 FXR1 GEM GLRA1 GPANK1 GPKOW GYS1 HGS HNRNPF HNRNPK HNRNPUL1 IMP3 INPPL1 INSC IQUB KANK2 KIAA0408 KIAA1217 KIFC3 MAPK1 MAPK3 MKRN3 MYO15B NAB2 NAF1 NCK1 NCKIPSD NEK6 NFKBID NHSL2 NOTCH3 NRBP1 OIP5 OSGIN1 PAK2 PAK5 PHETA1 PHF1 PIBF1 PLEKHN1 PLOD3 PNMA5 POLE2 POLR1C PPFIA3 PPIL6 PPP1R18 QARS1 RAD51D RBMX RIN1 ROPN1 RUNX1T1 SAFB2 SAXO1 SCNM1 SETD5 SH2D4A SHANK3 SOCS7 SPG21 SRCIN1 SYNPO2L TBC1D22B TCEANC TEAD4 TEPSIN TNS2 TRIM23 TRIM27 TRIM41 TSC1 TSGA10 TSGA10IP TXLNA USP2 VARS2 VCL VPS37B VPS37C WIPF2 ZBED1 ZBTB25 ZBTB7B ZC2HC1C ZC4H2 ZNF414
Entrez ID		8985	10174
HPRD ID		04347	11535
Ensembl ID		ENSG00000106397	ENSG00000120896
Uniprot IDs		O60568	O60504
PDB IDs		6FXK 6FXM 6FXR 6FXT 6FXX 6FXY 6TE3 6TEC 6TES 6TEU 6TEX 6TEZ 6WFV 8ONE	2CT3 2DLM 2NWM 2YUP
GO Terms Enriched among Interactors		None	Protein Binding Cytoskeleton Cytoplasm SH3 Domain Binding Adherens Junction Organization Adherens Junction Assembly Regulation Of Actin Cytoskeleton Organization Identical Protein Binding Regulation Of Actin Filament Organization Bergmann Glial Cell Differentiation Regulation Of Actin Filament-based Process Motile Cilium Zonula Adherens Assembly Protein Domain Specific Binding Regulation Of Cytoskeleton Organization Positive Regulation Of Cap-dependent Translational Initiation Interleukin-34-mediated Signaling Pathway Nucleus Glial Cell Differentiation Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase III Regulation Of Golgi Inheritance Centriole Cell Projection