PLOD3 and IP6K2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		PLOD3	IP6K2
Name		procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	inositol hexakisphosphate kinase 2
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Membrane Extracellular Matrix Extracellular Exosome	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cell Junction
	Molecular Function	Catalytic Activity Iron Ion Binding Protein Binding Procollagen-lysine 5-dioxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Transferase Activity Glycosyltransferase Activity L-ascorbic Acid Binding Procollagen Glucosyltransferase Activity Small Molecule Binding Metal Ion Binding Procollagen Galactosyltransferase Activity Dioxygenase Activity	Nucleotide Binding Inositol-1,3,4,5,6-pentakisphosphate Kinase Activity Inositol Hexakisphosphate Kinase Activity Diphosphoinositol Pentakisphosphate Kinase Activity Inositol Hexakisphosphate 5-kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Inositol 5-diphosphate Pentakisphosphate 5-kinase Activity Diphosphoinositol Tetrakisphosphate Kinase Activity Flavonoid Binding
	Biological Process	In Utero Embryonic Development Endothelial Cell Morphogenesis Protein O-linked Glycosylation Intracellular Protein Localization Peptidyl-lysine Hydroxylation Neural Tube Development Collagen Fibril Organization Collagen Metabolic Process Vasodilation Hydroxylysine Biosynthetic Process Epidermis Morphogenesis Lung Morphogenesis Basement Membrane Assembly	Lipid Metabolic Process Negative Regulation Of Cell Growth Inositol Phosphate Biosynthetic Process Positive Regulation Of Apoptotic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol Phosphate Biosynthetic Process Protein Stabilization Organophosphate Biosynthetic Process Cellular Response To Flavonoid
Pathways		Collagen biosynthesis and modifying enzymes	Synthesis of IPs in the nucleus Interferon alpha/beta signaling
Drugs		Ascorbic acid	None
GWAS		Blood protein levels ( 30072576 ) Cerebral amyloid angiopathy in Alzheimer’s disease ( 34020725 )	Adult body size ( 32376654 ) Age at first birth ( 34211149 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cognitive function ( 25644384 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Diastolic blood pressure ( 27841878 ) Eosinophil count ( 32888494 ) Experiencing mood swings ( 29500382 ) Feeling fed-up ( 29500382 ) General cognitive ability ( 29844566 ) HDL cholesterol ( 30275531 ) Household income (MTAG) ( 31844048 ) Inflammatory bowel disease ( 23128233 28067908 ) Lipoprotein (a) levels ( 33730874 ) Morning person ( 30696823 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Refractive error ( 32231278 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 28067908 25082827 ) Waist circumference adjusted for body mass index ( 34021172 )
Novel Interactors		None recorded	1 novel interactors: QRICH1
Interacting Genes		20 interacting genes: CCDC85B COIL COL17A1 CRIP3 DPPA2 EFHC2 EHMT2 FAM153A IP6K2 KCTD9 KHNYN L3MBTL3 LINC00839 NAB2 RAB3IP RALY RHOU RHOXF2 SORBS3 ZNF620	7 interacting genes: HSP90AA1 LNX2 MEOX2 PLOD3 PLSCR1 RBPMS ZBTB2
Entrez ID		8985	51447
HPRD ID		04347	07380
Ensembl ID		ENSG00000106397	ENSG00000068745
Uniprot IDs		O60568	B2RCP4 C9JRM0 Q9UHH9
PDB IDs		6FXK 6FXM 6FXR 6FXT 6FXX 6FXY 6TE3 6TEC 6TES 6TEU 6TEX 6TEZ 6WFV 8ONE	Not available
GO Terms Enriched among Interactors		None	Response To Unfolded Protein Rho GDP-dissociation Inhibitor Binding CTP Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process DATP Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Phosphatidylserine Biosynthetic Process Mercury Ion Binding Lead Ion Binding Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Hydroxylysine Biosynthetic Process Procollagen Glucosyltransferase Activity Procollagen-lysine 5-dioxygenase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Basement Membrane Assembly Procollagen Galactosyltransferase Activity MRNA CDS Binding