PLOD3 and CRIP3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		PLOD3	CRIP3
Name		procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	cysteine rich protein 3
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Membrane Extracellular Matrix Extracellular Exosome	Cytoplasm
	Molecular Function	Catalytic Activity Iron Ion Binding Protein Binding Procollagen-lysine 5-dioxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Transferase Activity Glycosyltransferase Activity L-ascorbic Acid Binding Procollagen Glucosyltransferase Activity Small Molecule Binding Metal Ion Binding Procollagen Galactosyltransferase Activity Dioxygenase Activity	Protein Binding Metal Ion Binding
	Biological Process	In Utero Embryonic Development Endothelial Cell Morphogenesis Protein O-linked Glycosylation Intracellular Protein Localization Peptidyl-lysine Hydroxylation Neural Tube Development Collagen Fibril Organization Collagen Metabolic Process Vasodilation Hydroxylysine Biosynthetic Process Epidermis Morphogenesis Lung Morphogenesis Basement Membrane Assembly	None
Pathways		Collagen biosynthesis and modifying enzymes	None
Drugs		Ascorbic acid	None
GWAS		Blood protein levels ( 30072576 ) Cerebral amyloid angiopathy in Alzheimer’s disease ( 34020725 )	Adult hearing difficulty ( 31564434 ) Age-related hearing impairment ( 34108613 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Diastolic blood pressure ( 30487518 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Estimated glomerular filtration rate ( 31152163 ) Height ( 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Hypertension ( 30487518 ) Mean arterial pressure ( 30487518 ) Pulse pressure ( 27841878 30487518 ) Systolic blood pressure ( 27841878 30487518 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		20 interacting genes: CCDC85B COIL COL17A1 CRIP3 DPPA2 EFHC2 EHMT2 FAM153A IP6K2 KCTD9 KHNYN L3MBTL3 LINC00839 NAB2 RAB3IP RALY RHOU RHOXF2 SORBS3 ZNF620	2 interacting genes: FHL3 PLOD3
Entrez ID		8985	401262
HPRD ID		04347	16755
Ensembl ID		ENSG00000106397	ENSG00000146215
Uniprot IDs		O60568	Q6Q6R5
PDB IDs		6FXK 6FXM 6FXR 6FXT 6FXX 6FXY 6TE3 6TEC 6TES 6TEU 6TEX 6TEZ 6WFV 8ONE	Not available
GO Terms Enriched among Interactors		None	Hydroxylysine Biosynthetic Process Basement Membrane Assembly Procollagen Galactosyltransferase Activity Procollagen Glucosyltransferase Activity Procollagen-lysine 5-dioxygenase Activity Epidermis Morphogenesis Peptidyl-lysine Hydroxylation Endothelial Cell Morphogenesis Protein Hydroxylation L-ascorbic Acid Binding Small Molecule Binding Lung Morphogenesis Extracellular Matrix Assembly Aspartate Family Amino Acid Metabolic Process Rough Endoplasmic Reticulum Neural Tube Development Epithelial Cell Morphogenesis Basement Membrane Organization Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Vasodilation Collagen Fibril Organization Amino Acid Biosynthetic Process Collagen Metabolic Process Dioxygenase Activity Stress Fiber Protein O-linked Glycosylation Iron Ion Binding